Search results for "HBc"
showing 4 items of 44 documents
Bromattujen palonestoaineiden rajoitusten vaikutus jätteiden hyödyntämiseen ja käsittelyyn
2012
Tässä tutkimuksessa selvitettiin bromattujen palonestoaineiden määrää eri jätejakeissa. Tutkitut yhdisteet olivat kaupalliset PBDE:t (PeBDE, OBDE ja DBDE) ja HBCD. Näiden yhdisteiden on todettu olevan haitallisia terveydelle ja ympäristölle sekä suoraan että välil-lisesti. PeBDE, OBDE ja HBCD ovat POP-yhdisteitä. Kyseisillä yhdisteillä on pääosin suojattu sähkö- ja elektroniikkalaitteita ja ajoneuvoja. Työ jakaantuu kirjalliseen ja kokeelliseen osioon. Kirjallisessa osiossa tarkasteltiin yhdis-teiden käyttökohteita ja käytön rajoituksia. Kokeellisessa osiossa tehtiin kenttämittauksia ja yhdisteanalyysejä kenttämittausten perusteella valikoiduista näytteistä. Yhdisteanalyysien avulla selvite…
Lamivudine monoprophylaxis for de novo HBV infection in HBsAg-negative recipients with HBcAb-positive liver grafts.
2011
We followed the efficacy of long-term lamivudine monotherapy in preventing development of de novo hepatitis B (DNHB) in a large cohort of hepatitis B surface antigen (HBsAg)-negative recipients with grafts from hepatitis B core antibody (HBcAb)-positive donors. Recipients were observed over a long follow-up. Between July 1999 and December 2008, 45 patients (median age 54, range 19-67) who were HBsAg negative before transplantation were included in the study of monoprophylaxis with lamivudine starting on post-operative day 1, and continuing for life. Mean follow-up: 37.9 months; median 32.1 months (range 2.4-117). No suspension of therapy was reported during the study. Post-transplantation, …
The affinities of monoclonal antibodies against core antigen of hepatitis B virus
1994
Four monoclonal antibodies generated against the recombinant core antigen of hepatitis B virus are investigated for antigen binding. All exhibit a similar affinity to polystyrene-sorbed antigen but only one of them interacts with native form of HBcAg (an assembled particle) in solution. The presence of 0.1% sodium dodecylsulphate is required for the binding of other three antibodies. The phenomenon can be interpreted as inaccessibility of the corresponding epitopes unless the multimeric antigen structure is disrupted. The core antigen coated on polystyrene is considered as a similar exposed structure.
Isolated Anti-HBc: Significance and Management.
2019
Hepatitis B virus (HBV) infection is prevalent worldwide and is associated with dramatic levels of morbidity and mortality. Isolated anti-HBc (IAHBc) is a particular serological pattern that is commonly found in immunocompromised patients. There is ongoing debate regarding the management of patients with IAHBc. Herein, we summarize the current guidelines and the newest evidence. The frequency of IAHBc is variable, with a higher prevalence in some populations, such as persons living with HIV and others immunocompromised patients. The risk of HBV reactivation depends on host factors (including immunosuppression) and viral factors. It is now well established that immunocompromised patients can…