Search results for "HD"

Bidirectional associations between cognitive functions and walking performance among middle-aged women

2022

Objective: This study investigated whether (1) cognitive functions change after the transition from the perimenopausal to the postmenopausal stage, (2) cognitive functions and walking are associated in middle-aged women, and (3) cognitive functions assessed in perimenopause are associated with walking after reaching the postmenopause or vice versa. Methods: In total, 342 women, categorized as early (n = 158) or late perimenopausal (n = 184), were included in the study and followed up until postmenopausal. Psychomotor speed, executive functions related to set-shifting and updating, working memory, and visual memory were assessed. Walking was assessed with walking speed, walking distance, and…

School-based group intervention in attention and executive functions: Intervention response and moderators

2022

ObjectiveThis study investigated the effects of a school-based skill-training intervention in attention control and executive functions for pupils with hyperactivity-impulsivity (H-I) and cognitive control (CC) deficits. The main aim was to examine whether the intervention differently influenced H-I and CC, and whether cognitive abilities or conduct problems moderated response to the intervention.MethodElementary school pupils from 41 schools participated the study and were divided into an intervention group (n = 71) and a waitlist control group (n = 77). Intervention outcomes were assessed with an inventory assessing executive function difficulties (including H-I and CC) completed by class…

Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus.

2021

Abstract BACKGROUND Increasing evidence shows obesity and poor metabolic health are associated with cognitive deficits, but the mechanistic connections have yet to be resolved. We studied rats selectively bred for low and high intrinsic aerobic capacity in order to test the association between low physical fitness, a genetic predisposition for obesity, and brain health. We hypothesized that low-capacity runner (LCR) rats with concurrently greater levels of adiposity would have increased hippocampal inflammation and reduced plasticity compared to the more physically fit high-capacity runner (HCR) rats. METHODS We examined markers for inflammation and brain plasticity in the hippocampi of LCR…

Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats

2023

Good aerobic fitness associates positively with cognitive performance and brain health and conversely, low aerobic fitness predisposes to neurodegenerative diseases. To study how genotype together with exercise, started at older age, affects brain and behavior, we utilized rats that differ in inherited aerobic fitness. Rats bred for Low Capacity for Running (LCR) are shown to display less synaptic plasticity and more inflammation in the hippocampus and perform worse than rats bred for a High Capacity for Running (HCR) in tasks requiring flexible cognition. Here we used middle-aged (∼ 16 months) HCR and LCR rats to study how genotype and sex associate with anxiety and neural information filt…

Executives’ Commitment to Information Security : Interaction between the Preferred Subordinate Influence Approach (PSIA) and Proposal Characteristics

2020

Two aspects of decision-making on information security spending, executives' varying preferences for how proposals should be presented and the framing of the proposals, are developed. The proposed model of executives' commitment to information security is an interaction model (in addition to the cost of a security solution, and the risk and the potential loss of a security threat) consisting of the interaction between an executive's preferred subordinate influence approach (PSIA), rational or inspirational, and the framing, positive or negative, of a security proposal. The interaction of these two constructs affects the executive's commitment to an information security proposal. The model i…

Tutkimusrahoitusta ja tutkijankoulutusta uudistettava

2020

Tutkimuksen rahoituksen kohdentaminen on yksi tiedepolitiikan ikuisuuskysymyksiä. Rahoitusta ja kohdentamista sekä perustana olevia rakenteita tulee uudistaa yhteiskunnan kehityksen ja muutosten mukana. Oikeastaan tämän tulisi tapahtua muutoksia ennakoiden. Pekka Neittaanmäki luo artikkelissaan mielenkiintoisen katsauksen tutkimusrahoitukseen ja siihen liittyvään tutkijankoulutukseen. Ytimenä on tieteellisen tiedon kehitys ja erityisesti tutkimuksen painotuksen muutokset suhteessa tieteellisen idean käytännön sovellusten tuottamiseen. Tältä pohjalta kirjoittaja esittää käytännön toimia suomalaisen tutkimusrahoituksen kehittämiseksi. nonPeerReviewed

Etelä-Savon työttömille suunnattavien ESR-hankkeiden kohdentuminen ja vaikuttavuus

1999

Fysioterapian ohjaustilanteen vuorovaikutus : fysioterapeuttien ja asiakkaiden käsityksiä vuorovaikutuksesta sekä sen kohdentamisesta ja mukauttamise…

2004

Muikun (Coregonus albula (L.)) ja kuoreen (Osmerus eperlanus (L.)) kohdevoimakkuuden kokeellinen mittaaminen

2008

Kohdistettu huijaussähköposti organisaatioiden tietoturvauhkana

2017

Tässä pro-gradu tutkielmassa käsitellään kohdistettua huijaussähköpos-tia organisaation tietoturvauhkana käyttäjien toiminnan näkökulmasta. Tutkielmassa kartoitettiin, mitkä tekijät ovat yhteydessä kohdistetulla huijaussähköpostilla huijatuksi tulemiseen. Tarkastelun kohteina olivat paitsi viestin ominaisuudet myös erilaiset yksilön ominaisuudet, kuten käyttäjän tietoisuus tietoturvariskeistä. Tutkielman aihe on tärkeä, koska organisaatiot ovat yhä riippuvaisempia tietojärjestelmien toiminnasta ja niissä olevista tiedoista. Kohdistetuista huijaussähköposteista voi aiheutua merkittäviä vahinkoja organisaatioille, ja mahdollisuus vahingoille on kasvanut viime vuosien aikana, kun teknologia ja…