Search results for "HD"
showing 10 items of 4547 documents
Oxygen Transfer from Trimethylamine N-oxide to CuI Complexes Supported by Pentanitrogen Ligands
2020
[N,N-bis(1-methyl-2-benzimidazolyl)methyl-N-(bis-2-pyridylmethyl)amine] ( L 1 ) and [N,N-bis(2-quinolylmethyl)-N-bis(2-pyridyl)methylamine] ( L 2 ) were employed to prepare Cu II and Cu I complexes for spectroscopic and structural characterization. [ L 1 Cu II (H 2 O)](NO 3 ) 2 and [ L 2 Cu II (NO 3 )]NO 3 have Jahn-Teller distorted octahedral geometries, and give rise to isotropic EPR spectra in frozen solution. [ L 1 Cu I (CH 3 CN)]OTf and [ L 2 Cu I (CH 3 CN)]OTf have distorted trigonal bipyramidal and tetrahedral solid-state structures, respectively. The N-donors display labile behavior in solution, based on variable-temperature 1 H NMR studies. Addition of trimethylamine N-oxide (Me …
"Table 2" of "Search for Higgs boson decays into a $Z$ boson and a light hadronically decaying resonance using 13 TeV $pp$ collision data from the AT…
2020
Efficiencies of the MLP selection, complete selection and total expected signal yields for each signal sample, assuming B$(H\to Z(Q/a))=100\%$ and $\sigma(pp\to H) = \sigma_\text{SM}(pp\to H)$. Pythia 8 branching fractions of $a$ are assumed using a $\tan\beta$ value of 1. The MLP efficiencies, total efficiencies, and expected yields are determined using MC samples, with uncertainties due to MC sample statistics, except for the expected background yield. The expected background yield and its uncertainty is calculated as described in the main text of the paper.
"Table 1" of "Search for Higgs boson decays into a $Z$ boson and a light hadronically decaying resonance using 13 TeV $pp$ collision data from the AT…
2020
Observed number of data events and expected number of background events in the signal region.
THE HDAC INHIBITOR ITF2357 (GIVINOSTAT) AS A KEY PLAYER IN EPIGENETIC TARGETING OF MELANOMA AND COLON CANCER CELLS
2023
Histone deacetylase inhibitors (HDACIs) are epigenetic compounds that have been recently considered for their promising anti-tumor activity. The aim of this PhD thesis was to elucidate and characterize the anti-tumor effect of the HDAC inhibitor ITF2357 (Givinostat) in melanoma and colon cancer cells that are characterized by oncogenic BRAF mutations. Interestingly, data reported in this thesis demonstrate that ITF2357 exerts a remarkable anti-tumor effect in melanoma cells by inducing a switch from a pro-survival autophagy to caspase-dependent apoptosis. The thesis provides the first evidences that ITF2357 is able to target oncogenic BRAF and oncogenic p53. The ITF2357 decreasing effect on…
Oncogenic BRAF and p53 Interplay in Melanoma Cells and the Effects of the HDAC Inhibitor ITF2357 (Givinostat)
2023
Oncogenic BRAF mutations have been widely described in melanomas and promote tumour progression and chemoresistance. We previously provided evidence that the HDAC inhibitor ITF2357 (Givinostat) targets oncogenic BRAF in SK-MEL-28 and A375 melanoma cells. Here, we show that oncogenic BRAF localises to the nucleus of these cells, and the compound decreases BRAF levels in both the nuclear and cytosolic compartments. Although mutations in the tumour suppressor p53 gene are not equally frequent in melanomas compared to BRAF, the functional impairment of the p53 pathway may also contribute to melanoma development and aggressiveness. To understand whether oncogenic BRAF and p53 may cooperate, a po…
Cross‐sectional associations between physical fitness and biomarkers of inflammation in children : the PANIC study
2023
Background Systemic low-grade inflammation has been proposed as an underlying pathophysiological mechanism for cardiometabolic diseases. We investigated the associations of physical fitness with systemic low-grade inflammatory state in a population sample of children. Methods Altogether 391 children aged 6–9 years were examined. Cardiorespiratory fitness (maximal power output, Wmax) was assessed by a maximal cycle ergometer test and neuromuscular fitness by hand grip strength, sit-up, standing long jump, 50-metre shuttle run, static balance, sit-and-reach, and box and block tests. Body fat percentage (BF%) and lean mass (LM) were assessed by dual-energy X-ray absorptiometry. High sensitivit…
Entrainment and its perturbation in the auditory cortex of the rat : phase and frequency modulations
2010
Tutkimuksen tavoitteena oli luoda oskillatorista tahdistamista rotan kuuloaivokuorella sekä valikoivasti häiritä sitä. Tahdistamista ei ole juuri lainkaan tutkittu aiemmin, joten tutkimuksessa yritettiin löytää uutta tietoa käyttäen ainutlaatuista kokeellista asetelmaa. Viisitoista rottaa nukutettiin uretaanilla ja niiltä mitattiin paikallisia kenttäpotentiaaleja (local field potentials,LFPs) kovakalvon päälle sijoitetun solun ulkopuolisen mikroelektrodin avulla. Neljässä pääkokeessa luotiin 2,5 Hz tahdistamista yhdeksän ärsykkeen äänijonoilla, missä tahdistamisäänen taajuus oli 4000 Hz ja häiritsevän äänen taajuus oli 4500 Hz. Häirintä oli aina kahdeksannessa äänessä, jonka vaihetta ja/tai…
Liikenne, yhdyskuntasuunnittelu ja paikallistalous : Kokkolan ohikulkutien vaikutukset
1997
Tutkimuksessa on käsitelty liikennettä, liikenne-ja yhdyskuntasuunnittelua sekä paikallistaloutta. Tapauskohtaisesti on tarkasteltu Kokkolan mahdollista ohikulkutiehanketta. Raportin tehtävänä on ollut tähän hankkeeseen liittyvien eri näkökulmien valottaminen, ohikulkutiehen liittyvien taloudellisten ilmiöiden arvioiminen sekä liikenteen merkityksen hahmottaminen yhdyskuntien suunnittelun kannalta. Tieinvestoinnista syntyy erilaisia vaikutuksia. Kokkolassa onkin esitetty näkemyksiä, että uuden eteläisen ohikulkutien mukanaan tuomat muutokset vaikuttaisivat myös keskustan elinkeinoelämään ja elävyyteen. Uusi tie vähentää ruuhkia ja parantaa yleisesti elinkeinoelämän toimintamahdollisuuksia. …
Kuvallistettu kuuluminen : valokuvahaastattelu ja visuaalinen analyysi paikkasuhteiden tutkimuksessa
2016
Spatial belonging is understood as a multidimensional process in which pictorial representation of the environment also plays an important role. However, various intersecting discursive and personal dimensions in the relations between images, photography and spatial belonging make researching the topic quite challenging. This article focuses on a methodology that combines photo-elicitation and visual analysis to elucidate the relations between images and spatial belonging, and to explore the ways in which the mental images created by discursive landscape imagery can affect the formation of people’s place relations and feelings of spatial belonging. The article draws from a research project …