Search results for "HD"
showing 10 items of 4547 documents
Highly Enantioselective Kinetic Resolution of Michael Adducts through N-Heterocyclic Carbene Catalysis: An Efficient Asymmetric Route to Cyclohexenes
2018
Ahighly efficient strategy for the kinetic resolu-tion of Michael adductswas realized using achiral N-het-erocyclic carbene catalyst.The kinetic resolution providesanew convenientroute to single diastereomers of cyclo-hexenes and Michael adducts in good yields with highenantiomeric excesses (up to 99 % ee with aselectivityfactor of up to 458). This “two flies with one swat” con-cept allows the synthesis of these two synthetically valua-ble compound classes at the same time by asingle trans-formation. peerReviewed
A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and sibli…
2011
Item does not contain fulltext BACKGROUND: Impulsive drive for immediate reward (IDIR) and delay aversion are dissociable elements of the preference for immediate over delayed rewards seen in attention-deficit/hyperactivity disorder (ADHD). We hypothesized that IDIR would be associated with dopamine regulating genes and delay aversion would be associated with serotonin-regulating genes. METHODS: Impulsive drive for immediate reward and delay aversion were measured in 459 male children and adolescents (328 ADHD and 131 unaffected siblings) with a laboratory choice task. The sample was genotyped for the 5HTT (SLC6A4) promoter serotonin-transporter-linked polymorphic region polymorphism and a …
Dynamic changes in the subcellular distribution of the tobacco ROS-producing enzyme RBOHD in response to the oomycete elicitor cryptogein.
2014
Highlight text The oomycete elicitor cryptogein triggers the relocation of RBOHD from intracellular compartments to the plasma membrane in tobacco cells. This suggests that intracellular trafficking is a potential determinant of RBOHD activity.
The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network
2021
AbstractTo investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components of HRQoL and Beck Depression Inventory (BDI) to assess depressive symptoms. Depressive symptoms were categorized into minimal (BDI < 10), non-melancholic and melancholic types of depression. The ePRS-IRs were calculated for the hippocampal (hePRS-IR) and the mesocorticolim…
Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP Depletion
2021
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with a dismal prognosis. Here, we show how an inhibition of de novo dNTP synthesis by the ribonucleotide reductase (RNR) inhibitor hydroxyurea and an inhibition of epigenetic modifiers of the histone deacetylase (HDAC) family affect short-term cultured primary murine PDAC cells. We used clinically relevant doses of hydroxyurea and the class 1 HDAC inhibitor entinostat. We analyzed the cells by flow cytometry and immunoblot. Regarding the induction of apoptosis and DNA replication stress, hydroxyurea and the novel RNR inhibitor COH29 are superior to the topoisomerase-1 inhibitor irinotecan which is used to treat PDAC. Ent…
In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi)
2020
Histone deacetylase inhibitors (HDACi) are already approved for the therapy of leukemias. Since they are also emerging candidate compounds for the treatment of non-malignant diseases, HDACi with a wide therapeutic window and low hazard potential are desirable. Here, we investigated a panel of 12 novel hydroxamic acid- and benzamide-type HDACi employing non-malignant V79 hamster cells as toxicology guideline-conform in vitro model. HDACi causing a &ge
Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus
2012
Coats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex. Consistent with the observation of shortened telomeres in an Arabidopsis CTC1 mutant and the phenotypic overlap of Coats plus with the telomeric maintenance disorders comprising dyskeratosis congenita, we observed shortened telomeres in three individuals with Coats plus and an increase in spontaneous γ 3H2AX-positive cells in cell lines derived from two affected individual…
La guerra de sucesión en Valencia. Retrospectiva historiográfica y estado de la cuestión
2007
Se cumplen 300 años de la batalla de Almansa, un hito que marcó el cambio de rumbo de la historia de los valencianos tras el fracaso de la rebelión austracista. Es el momento de hacer un recorrido historiográfico desde el siglo XVIII hasta nuestros días, con especial atención a la etapa que se abre en los años 1960, destacando las distintas aportaciones y los interrogantes que aún siguen abiertos. There are fulfilled 300 years of the battle of Almansa, a milestone that changed the course of Valencian's history after the defeat of the austracist rebellion. It is the moment to do an historiographic revision from the 18th century until our days, giving special attention to the period beginning…
Alaraajojen luun mineraalipitoisuuden ja polven nivelruston väliset yhteydet postmenopausaalisilla naisilla
2011
Tämän poikkileikkaustutkimuksen tarkoituksena oli selvittää luuston (reisiluun kaula, lanneranka L2-L4) mineraalitiheysarvojen ja polven nivelruston (reisiluu, sääriluu) eheyttä kuvaavien dGEMRIC-arvojen välistä yhteyttä postmenopausaalisilla naisilla. Tutkimukseen rekrytoitiin 82 naista (keskimääräiseltä iältään 57,7 vuotta, SD 4,2) lehti-ilmoituksen perusteella. Sisäänottokriteerinä oli rtg:llä arvioidun Kellgren-Lawrence-luokituksen (K/L) mukaan ensimmäisen (K/L1) tai toisen (K/L2) asteen lievä polven nivelrikko. Reisiluun kaulan ja lannerangan (L2–L4) BMC-arvot mitattiin DXA-laitteistolla. Tutkimushenkilöillä ei ollut osteoporoosia, jonka kynnysarvona käytettiin T-arvoa >2,5. Tibian ja …
Vapaa-ajan fyysisen aktiivisuuden yhteys painoindeksiin ja kehon rasvaprosenttiin : aineistojen yhdistäminen
2016
Mariann Slotte-Jana (2016). Vapaa-ajan fyysisen aktiivisuuden yhteys painoindeksiin ja kehon rasvaprosenttiin – aineistojen yhdistäminen. Terveystieteiden laitos. Jyväkylän yliopisto, liikuntalääketieteen pro gradu –tutkielma, 46 s., 4 liitettä. Fyysisen aktiivisuuden määrän selvittämiseksi käytetään useita erilaisia kyselyjä, mikä hankaloittaa tulosten tarkastelua eri tutkimusten välillä. Tämän tutkielman tarkoituksena oli selvittää voidaanko erilaisilla vapaa-ajan liikunta-aktiivisuuskyselyillä mitattua fyysisen aktiivisuuden määrää luokitella yhdenmukaisesti ja onko luokilla yhteys painoindeksiin ja kehon rasvaprosenttiin yksittäisiä aineistoja analysoitaessa. Tutkielmassa myös yhdistett…