Search results for "HD"

Loss of the Sin3A/Rpd3 Histone De-Acetylase Complex Causes Telomeric Fusions

2009

Loss of the Sin3A/Rpd3 Histone De-Acetylase Complex Causes Polytene Chromosome Telomeric Fusions

2009

HISTONE DEACETYLASE INHIBITORS SENSITIZE HEPATOMA CELLS TO TRAIL_INDUCED APOPTOSIS

2008

BIOLOGICAL EFFECTS OF JAHA, A NEW HISTONE DEACETYLASE INHIBITOR, ON CANCER CELLS FROM HUMAN BREAST EPITHELIUM

The histone deacetylase inhibitors (HDACis) are a class of chemically heterogeneous anticancer agents of which suberoylanilide hydroxamic acid (SAHA) is a prototypical member. SAHA derivatives may be obtained by the three-dimensional manipulation of the SAHA aryl cap, such as the incorporation of a ferrocene unit like that present in Jay Amin hydroxamic acid (JAHA) and homo-JAHA (Spencer et al., 2011). These metal-based SAHA analogues have been tested for their cytotoxic activity toward triple-negative MDA-MB231 breast cancer cells. The results obtained indicate that of the two compounds tested, only JAHA was prominently active on breast cancer cells with an IC50 of 8.45 μM at 72 h of treat…

What explains development : development strategy for low human development index countries

2009

Development discourses of the low human development index : countries in UN post-2015 discussion

2015

This study is about development discourses and agents of the countries with low Human Development Index (HDI) in Africa. It is based on six UN Post-2015 national consultations. These six nations are Burkina Faso, the Democratic Republic of Congo, Ethiopia, Mozambique, Liberia and Zambia. The criteria of data selection involve the level of HDI, language, format of the report and geographical location. The idea about development as discursive constructed social reality is at the focus of theoretical framework. The method is Discourse Analysis (DA) with some Foucauldian characteristics. The research questions are: What kind of specific development discourses and agentive roles are there in pol…

STUDIES ON FACTORS INFLUENCING HIGH-DENSITY LIPOPROTEIN FUNCTIONALITY AND REVERSE CHOLESTEROL TRANSPORT

Coronary artery disease (CAD) in dyslipidemic and diabetic subjects remains the leading cause of death in the Western society. Current therapeutic strategies to prevent cardiovascular diseases are primarily based on the use of statins, which inhibit key enzyme in the cholesterol synthesis, HMG-CoA reductase. Another prominent risk factor for developing premature atherosclerosis is the low levels of high-density lipoprotein cholesterol (HDL-C). Despite documented benefits of statins a good proportion of individuals still remain at a higher risk of developing CAD. Therefore, focus has shifted on HDL-raising therapeutics to further improve the CV outcome. While Niacin and fenofibrate have not …

Bassa prevalenza delle LDL aterogene piccole e dense in una popolazione mediterranea

2002

Dosimetric perturbations of a lead shield for surface and interstitial high-dose-rate brachytherapy.

2014

In surface and interstitial high-dose-rate brachytherapy with either (60)Co, (192)Ir, or (169)Yb sources, some radiosensitive organs near the surface may be exposed to high absorbed doses. This may be reduced by covering the implants with a lead shield on the body surface, which results in dosimetric perturbations. Monte Carlo simulations in Geant4 were performed for the three radionuclides placed at a single dwell position. Four different shield thicknesses (0, 3, 6, and 10 mm) and three different source depths (0, 5, and 10 mm) in water were considered, with the lead shield placed at the phantom surface. Backscatter dose enhancement and transmission data were obtained for the lead shields…

Risk assessment of component failure modes and human errors using a new FMECA approach: application in the safety analysis of HDR brachytherapy

2014

Failure mode, effects and criticality analysis (FMECA) is a safety technique extensively used in many different industrial fields to identify and prevent potential failures. In the application of traditional FMECA, the risk priority number (RPN) is determined to rank the failure modes; however, the method has been criticised for having several weaknesses. Moreover, it is unable to adequately deal with human errors or negligence. In this paper, a new versatile fuzzy rule-based assessment model is proposed to evaluate the RPN index to rank both component failure and human error. The proposed methodology is applied to potential radiological over-exposure of patients during high-dose-rate brach…