Search results for "HD"
showing 10 items of 4547 documents
Dictating the boundaries of ab/normality: a critical discourse analysis of the diagnostic criteria for attention deficit hyperactivity disorder and h…
2017
In this article we report the findings of a critical discourse analysis of the diagnostic criteria for attention deficit hyperactivity disorder (ADHD) and hyperkinetic disorder (HD) in two clinical manuals – Diagnostic and Statistical Manual of Mental Disorders, 5th edition and International Classification of Diseases, 10th edition. We examine the actions (behaviors) that are said to indicate the presence of ADHD/HD and analyze what the inclusion of these actions reveals about the relationship between ADHD/HD, cultural knowledge, and values. Our analysis reveals that both manuals use subjective, value-laden language to construct a mentally ill individual in opposition to an unseen, supposed…
HL7 FHIR with SNOMED-CT to Achieve Semantic and Structural Interoperability in Personal Health Data: A Proof-of-Concept Study
2022
Heterogeneity is a problem in storing and exchanging data in a digital health information system (HIS) following semantic and structural integrity. The existing literature shows different methods to overcome this problem. Fast healthcare interoperable resources (FHIR) as a structural standard may explain other information models, (e.g., personal, physiological, and behavioral data from heterogeneous sources, such as activity sensors, questionnaires, and interviews) with semantic vocabularies, (e.g., Systematized Nomenclature of Medicine—Clinical Terms (SNOMED-CT)) to connect personal health data to an electronic health record (EHR). We design and develop an intuitive health coaching (eCoach…
Histone Deacetylase Inhibitors in the Treatment of Hematological Malignancies and Solid Tumors
2010
The human genome is epigenetically organized through a series of modifications to the histone proteins that interact with the DNA. In cancer, many of the proteins that regulate these modifications can be altered in both function and expression. One example of this is the family of histone deacetylases (HDACs), which as their name implies remove acetyl groups from the histone proteins, allowing for more condensed nucleosomal structure. HDACs have increased expression in cancer and are also believed to promote carcinogenesis through the acetylation and interaction with key transcriptional regulators. Given this, small molecule histone deacetylases inhibitors have been identified and developed…
Fenomenologinen selvitys teknologian ja ruumiin suhteesta : ruumiin laajentaminen teknologian avulla
2014
Tämä tutkielma käsittelee teknologiaa ja ruumista fenomenologisesta näkökulmasta. Tarkoituksenani on selvittää teknologian vaikutus ruumiillisuuteen ja ruumiillinen laajentaminen teknologian avulla. Lisäksi käsittelen yleisesti ruumiillisuutta ja teknologiaa fenomenologisesta viitekehyksestä ja molempien vaikutusta kokonaisvaltaiseen tapaan olla maailmassa. Fenomenologisen viitekehyksen muodostan nojaamalla pääasiallisesti kolmen aihetta käsitelleen filosofin työhön. Ensinnäkin ranskalaisfilosofi Maurice Merleau-Pontyn filosofia luo viitekehyksen ruumiillisuudelle, kun taas saksalaisfilosofi Martin Heidegger tarjoaa lähtökohdan teknologia-näkökulman käsittelylle. Näiden molempien filosofien…
The sensitization of HepG2 and HT29 cells to TRAIL-induced apoptosis by histone deacetylase inhibitors is mediated by down-regulation of AKT and NF-k…
2008
Metal-Organic Nanocapsules with Functionalized s-Heptazine Ligands.
2020
A metalloorganic capsule was synthesized where the ligand is a derivative of heptazine with three carboxylic groups that are coordinated to CuII cations, forming paddle-wheel motifs. Each nanocapsule is neutral, with 12 CuII centers and 8 ligands adopting a rhombicuboctahedron shape. It has almost 3 nm diameter, and the main intermolecular interactions in the solid are π··· π stacking between the C6N7 heptazine moieties. The nanocapsules can form monolayers deposited on graphite as observed by atomic force microscopy, which confirms their stability in solution. peerReviewed
Tarve laihduttaa : kyse ei ollutkaan pelkistä kiloista
2016
Jokinen, Emmi (2016). Tarve laihduttaa ― kyse ei ollutkaan pelkistä kiloista. Liikuntakasva- tuksen laitos, Jyväskylän yliopisto, liikuntapedagogiikan pro gradu –tutkielma, 56 sivua, 1 liite. Pro gradu –tutkielmani keskeinen tavoite oli selvittää kuinka tutkittavat henkilöt kuvaavat painon kertymistä, sen syitä ja toisaalta onnistunutta painonpudotusta ja sen taustalla vaikutta- via tekijöitä. Tavoitteena oli lisätä ymmärrystä siitä, mitkä tekijät vaikuttavat lihomiseen ja laihtumiseen. Tavoitteena oli myös kerätä kokemuksellista tietoa painonpudotuksesta yhtei- sössä nimeltä Herbalife. Tutkimus on toteutettu laadullisena tutkimuksena ja sen tieteenfilosofinen lähtökohta on feno- menologis-…
Physiotherapists' lived experiences of decision making in therapeutic encounters with persons suffering from whiplash-associated disorder: A hermeneu…
2020
Conceptual discussions related to clinical reasoning and decision making have evolved over the years from biomedical to incorporating more holistic approach to reasoning. Empirical studies exploring clinical reasoning and decision making in physiotherapy practice have mostly focused on aspects of managing persons with low back pain, such as exercise prescription, education and communicating diagnosis. There is a paucity of studies exploring decision making in whiplash‐associated disorder (WAD); thus, the aim of this study was to explore the physiotherapists' lived experiences of decision making related to treating persons with WAD. A qualitative research design based on hermeneutic phenomen…
QPO emission from moving hot spots on the surface of neutron stars: a model
2009
We present recent results of 3D magnetohydrodynamic simulations of neutron stars with small misalignment angles, as regards the features in lightcurves produced by regular movements of the hot spots during accretion onto the star. In particular, we show that the variation of position of the hot spot created by the infalling matter, as observed in 3D simulations, can produce high frequency Quasi Periodic Oscillations with frequencies associated with the inner zone of the disk. Previously reported simulations showed that the usual assumption of a fixed hot spot near the polar region is valid only for misalignment angles relatively large. Otherwise, two phenomena challenge the assumption: one …
A sensitive study of the peculiar jet structure HST-1 in M87
2013
To obtain a better understanding of the location and mechanisms for the production of the gamma-ray emission in jets of AGN we present a detailed study of the HST-1 structure, 0.8 arcsec downstream the jet of M87, previously identified as a possible candidate for TeV emission. HST-1 shows a very peculiar structure with superluminal as well as possible stationary sub-components, and appears to be located in the transition from a parabolic to a conical jet shape, presumably leading to the formation of a recollimation shock. This scenario is supported by our new RHD simulations in which the interaction of a moving component with a recollimation shock leads to the appearance of a new superlumin…