Search results for "HECK"

showing 10 items of 682 documents

Efficacy of Immune Checkpoint Inhibitors Alone or in Combination With Chemotherapy in NSCLC Harboring ERBB2 Mutations

2021

Abstract Introduction In contrast to other driver mutations, no targeted therapies have yet been approved in ERBB2-mutated NSCLC (HER2mu NSCLC). Nevertheless, several compounds have revealed promising early efficacy data, which need to be evaluated in the context of current standard approaches. Although data on the efficacy of immune checkpoint inhibitors (ICIs) in second or subsequent lines of treatment remain limited and conflicting, there are virtually no data on patient outcome under ICI/platinum-doublet combinations in the first-line setting. Methods We retrospectively evaluated outcomes of patients with HER2mu NSCLC treated with ICI alone or in combination with chemotherapy within the…

Pulmonary and Respiratory MedicineOncologymedicine.medical_specialtyLung NeoplasmsStandard of careReceptor ErbB-2Immune checkpoint inhibitorsmedicine.medical_treatmentMedizinPatient characteristicsContext (language use)Internal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansGenomic medicineLung cancerImmune Checkpoint InhibitorsRetrospective StudiesChemotherapybusiness.industryImmunotherapymedicine.diseaseOncologyMutationbusiness
researchProduct

A straightforward copper-free palladium methodology for the selective alkynylation of a wide variety of S-, O-, and N-based mono- and diheterocyclic …

2009

Abstract High-yield alkynylations are successfully achieved by a simple and widely accessible catalytic system for an unprecedented variety of heterocyclic bromides and chlorides in position -2, -3 or -5: pyridine, quinoline, thiophene, furan, thiazole, benzothiazole, pyrimidine, pyridazine, pyrazine, dioxepin halides are efficiently functionalized in short time reactions. This copper-free methodology employs 1 mol % palladium only, with inexpensive PPh3 and amine base. The ionic liquid solvent allows a straigtforward separation of products and recycling opportunity. Unsuitable substrates and secondary reactions are also reported in order to point out further progress in cross-coupling usin…

Pyrazine010405 organic chemistry[CHIM.ORGA]Chemical Sciences/Organic chemistryOrganic ChemistryQuinolinechemistry.chemical_element010402 general chemistry01 natural sciencesBiochemistryCombinatorial chemistry0104 chemical sciencesPyridazinechemistry.chemical_compoundchemistryBenzothiazoleHeck alkynylation reaction[ CHIM.ORGA ] Chemical Sciences/Organic chemistryDrug DiscoveryIonic liquidThiopheneThiazoleComputingMilieux_MISCELLANEOUSPalladium
researchProduct

Residential Exposure to Outdoor Air Pollution during Pregnancy and Anthropometric Measures at Birth in a Multicenter Cohort in Spain

2011

Background: A growing body of research suggests that prenatal exposure to air pollution may be harmful to fetal development. We assessed the association between exposure to air pollution during pregnancy and anthropometric measures at birth in four areas within the Spanish Children’s Health and Environment (INMA) mother and child cohort study. Methods: Exposure to ambient nitrogen dioxide (NO2) and benzene was estimated for the residence of each woman (n = 2,337) for each trimester and for the entire pregnancy. Outcomes included birth weight, length, and head circumference. The association between residential outdoor air pollution exposure and birth outcomes was assessed with linear regress…

Questionnaires:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Environmental Monitoring [Medical Subject Headings]Fetus -- CreixementPediatricsHealth Toxicology and MutagenesisEspañaair pollution:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Cohort StudiesbenzenebirthRecién NacidoPregnancyResidence CharacteristicsSurveys and Questionnaires:Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants::Air Pollutants [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposure [Medical Subject Headings]Birth WeightBody SizeMedicineProspective StudiesProspective cohort studyTamaño Corporal:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings]Vehicle Emissions:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]Dióxido de NitrógenoPeso al NacerAir PollutantsInhalation ExposureanthropometryAdultoDistribución Espacial de la Población:Chemicals and Drugs::Complex Mixtures::Vehicle Emissions [Medical Subject Headings]Adulto JovenEstudios ProspectivosAire -- Contaminació -- Efectes fisiològics -- EpidemiologiaExposición MaternaHumanos:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Inhalation Exposure [Medical Subject Headings]Maternal ExposureFemeninaInfant Small for Gestational AgeCohort:Named Groups::Persons::Age Groups::Infant::Infant Newborn::Infant Low Birth Weight::Infant Small for Gestational Age [Medical Subject Headings]:Chemicals and Drugs::Inorganic Chemicals::Nitrogen Compounds::Nitrogen Oxides [Medical Subject Headings]Emisiones de VehículosFemalepregnancyEnvironmental MonitoringCohort studyAdultmedicine.medical_specialty:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]nitrogen dioxideEmbarazoBirth weightMonitoreo del AmbienteExposición por Inhalación:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size [Medical Subject Headings]:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]Young AdultRecién Nacido Pequeño para la Edad Gestacional:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]HumansPregnancybusiness.industryResearchBencenoInfant NewbornPublic Health Environmental and Occupational Healthbirth weightAnthropometrymedicine.disease:Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Residence Characteristics [Medical Subject Headings]Confidence interval:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons Cyclic::Hydrocarbons Aromatic::Benzene [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies [Medical Subject Headings]:Check Tags::Female [Medical Subject Headings]Spain:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings]Contaminantes del AireSmall for gestational ageEstudios de CohortesbusinessDemographyEnvironmental Health Perspectives
researchProduct

The endoperoxide ascaridol shows strong differential cytotoxicity in nucleotide excision repair-deficient cells

2011

Targeting synthetic lethality in DNA repair pathways has become a promising anti-cancer strategy. However little is known about such interactions with regard to the nucleotide excision repair (NER) pathway. Therefore, cell lines with a defect in the NER genes ERCC6 or XPC and their normal counterparts were screened with 53 chemically defined phytochemicals isolated from plants used in traditional Chinese medicine for differential cytotoxic effects. The screening revealed 12 drugs that killed NER-deficient cells more efficiently than proficient cells. Five drugs were further analyzed for IC50 values, effects on cell cycle distribution, and induction of DNA damage. Ascaridol was the most effe…

RAD23BDNA RepairDNA repairDNA damageCyclohexane MonoterpenesBiologyToxicologyCell LineInhibitory Concentration 50HumansCytotoxic T cellMedicine Chinese TraditionalPharmacologyDose-Response Relationship DrugCell cycleAntineoplastic Agents PhytogenicMolecular biologyPeroxidesG2 Phase Cell Cycle CheckpointsCell cultureCancer cellMonoterpenesM Phase Cell Cycle CheckpointsReactive Oxygen SpeciesDNA DamageDrugs Chinese HerbalNucleotide excision repairToxicology and Applied Pharmacology
researchProduct

Team dynamics in emergency surgery teams: results from a first international survey

2021

Abstract Background Emergency surgery represents a unique context. Trauma teams are often multidisciplinary and need to operate under extreme stress and time constraints, sometimes with no awareness of the trauma’s causes or the patient’s personal and clinical information. In this perspective, the dynamics of how trauma teams function is fundamental to ensuring the best performance and outcomes. Methods An online survey was conducted among the World Society of Emergency Surgery members in early 2021. 402 fully filled questionnaires on the topics of knowledge translation dynamics and tools, non-technical skills, and difficulties in teamwork were collected. Data were analyzed using the softwa…

RD1-811media_common.quotation_subjecteducationTrauma leadersContext (language use)Knowledge translationTrauma leaderTrauma teams Knowledge translation Team dynamics Non-technical skills Trauma leadersSettore SECS-P/07 - Economia AziendaleMultidisciplinary approachKnowledge translationSurveys and QuestionnairesHealth careMedicineHumansNon-technical skillknowledge translation; non-technical skills; team dynamics; trauma leaders; trauma teams; humans; surveys and questionnaires; patient care teamFunction (engineering)Trauma teamsNon-technical skillsmedia_commonPatient Care TeamMedical educationTeamworkRC86-88.9business.industryKnowledge translation; Non-technical skills; Team dynamics; Trauma leaders; Trauma teamsCorrectionMedical emergencies. Critical care. Intensive care. First aidChecklistEmergency MedicineSurgeryThe InternetTeam dynamicsTeam dynamicbusinessTrauma teamResearch Article
researchProduct

Immunotherapy-Based Treatments of Hepatocellular Carcinoma: AJR Expert Panel Narrative Review

2022

The advent of immunotherapy for patients with hepatocellular carcinoma (HCC) has changed the treatment landscape and conferred a survival benefit on patients with advanced HCC, who typically have a very poor prognosis. The most pronounced improvements in response, as documented by standardized response criteria based on CT or MRI, have been achieved when immunotherapy is combined with other systemic or locoregional therapies. Immune checkpoint inhibitor treatments result in unique patterns on CT and MRI that challenge the application of conventional response criteria such as RECIST, modified RECIST, and European Association for the Study of the Liver criteria. Thus, newer criteria have been…

RECISTlocoregional therapyimmune checkpoint inhibitorRadiology Nuclear Medicine and imaginghepatocellular carcinomaimmunotherapyGeneral Medicinemultikinase inhibitormRECISTCTMRIAmerican Journal of Roentgenology
researchProduct

New re-bordering left them alone and neglected: Czech cross-border commuters in German-Czech borderland

2022

The article focuses on the impact of the new re-bordering, caused by the COVID-19 pandemic, on the functional, ideational and institutional dimension of cross-border integration, as perceived by the Czech cross-border commuters employed on the German side of the Euroregion Elbe Labe. The interviews with forty cross-commuters showed that they were left alone in these times of re-bordering and became victims of non-coordination between Czechia and Germany. Yet, cross-border commuting seems to have survived the first pandemic waves and the German labour market will continue to attract the Czech workforce despite that fact the pandemic has introduced a major uncertainty associated with the bord…

Re-borderingGeography Planning and DevelopmentCOVID-19cross-border commutersCzech-German borderlandborder checksDemographyEuropean Societies
researchProduct

On strongly tactical codes

1986

We study perfect error correcting codes in which the codewords are protected by Hamming spheres of distinct protective radii. These codes have been introduced by Cohen, Montaron and Frankl [3, 4, 10].

Reed–Solomon error correctionConcatenated error correction codeTurbo codeForward error correctionConstant-weight codeLow-density parity-check codeError detection and correctionHamming codeAlgorithmComputer Science::Cryptography and SecurityComputer Science::Information TheoryMathematics
researchProduct

Empirical evaluation of home-based reablement: A review

2021

Home-based reablement (HBR) aims to restore or increase patients’ level of functioning, thereby increasing the patients’ self-reliance and consequently decreasing their dependence on healthcare services. To date, the evidence on whether HBR is an efficient method has not been comprehensively reviewed. The aim of this study was to provide a concise summary of relevant existing findings. In addition, we provide a critical constructive assessment of the publications reflecting the extant research.  The relevant literature on this topic was identified through a systematic search of appropriate databases. Thereafter, we screened the studies, first by title, followed by abstract and then by asses…

Rehabilitationbusiness.industryReablement economic/econometric evaluation rehabilitation RCT technology assessment toolmedicine.medical_treatmentApplied psychologyLevel of functioningHome basedChecklistHB1-3840External validityVDP::Samfunnsvitenskap: 200::Økonomi: 210Quality of life (healthcare)Multidisciplinary approachHealth caremedicineEconomic theory. DemographyPublic aspects of medicineRA1-1270businessPsychology
researchProduct

Reporting guidelines for health research: protocol for a cross-sectional analysis of the EQUATOR Network Library

2019

© Author(s) (or their employer(s)) 2019.

Research ReportBiomedical ResearchCross-sectional studyeducationSpecialtyMEDLINEGuidelines as Topic03 medical and health sciences0302 clinical medicineProtocolHumansresearch reportingMedicine1506030212 general & internal medicinePublishingData abstractionMedical educationbusiness.industry1711General MedicineTransparency (behavior)AuthorshipChecklist3. Good healthReview Literature as TopicResearch NetworksResearch DesignMedical Publishing and Peer ReviewScientific CollaborationReporting GuidelinesResearch reportingCitationRaw databusinessNetwork Analysis030217 neurology & neurosurgeryBMJ Open
researchProduct