Search results for "HECK"
showing 10 items of 682 documents
RASSF1A inhibits estrogen receptor alpha expression and estrogen-independent signalling: implications for breast cancer development
2012
The Ras association domain family 1 isoform A (RASSF1A) is a tumor suppressor whose inactivation is implicated in the development of many human cancers, including breast carcinomas. Little is known about the tumor-suppressive function of RASSF1A in breast tissue and whether its inactivation is mechanistically involved in the initiation and progression of breast tumors. Here, we show that RASSF1A inhibits breast cancer growth in vivo, and suppresses estrogen receptor (ERα) expression and function. Reconstitution of RASSF1A in MCF7 cells led to decreased ERα levels and reduced sensitivity to estrogen (E2). Concomitantly, we observed decreased expression of Id1 as well as the E2-responsive gen…
Sterigmatocystin: Occurrence, toxicity and molecular mechanisms of action – A review
2020
The mycotoxin sterigmatocystin (STE) is produced mainly by Aspergillus fungi. It has been reported to occur in grains and grain-based products, cheese, coffee, spices and beer. The STE is a known biogenic precursor of aflatoxin B1, sharing with it several structural and biological similarities. The STE has been shown to be hepatotoxic and nephrotoxic in animals and it has been classified as possible human carcinogen (group 2B) by IARC. The STE has been reported to cause a marked decrease in cell proliferation in different mammalian cells. Data available on literature suggest that the cellular mechanisms underlying STE-induced toxicity include the induction of oxidative stress, mitochondrial…
Hiperplasia epitelial focal: una rara enfermedad en nuestro medio
2005
La hiperplasia epitelial focal es una afección benigna asintomática y de muy baja frecuencia en nuestro medio. Aparece como pápulas en labio inferior principalmente, aunque se pueden localizar en mucosa retrocomisural y lengua y con menos frecuencia en labio superior, encía y paladar. Presentamos un caso clínico de una niña de 9 años, saharaui con lesiones que clínica e histológicamente se corresponden con una hiperplasia epitelial focal. Focal epithelial hyperplasia is a benign, asymptomatic disease, occurring with very low frequency within our population. It appears as papules, principally on the lower lip, although it can also be found on the retro-commissural mucosa and tongue, and less…
Hiperplasia multifocal del epitelio: Reporte de nueve casos
2005
La hiperplasia multifocal del epitelio (HME) conocida también como hiperplasia epitelial focal, enfermedad de Heck ó hiperplasia multifocal del epitelio por papiloma virus, se caracteriza por la aparición de lesiones múltiples en la mucosa de la cavidad bucal en población pediátrica y se asocia a la presencia del virus papiloma humano. El objetivo de este estudio fue conocer las características clínico-patológicas de los casos diagnosticados de esta enfermedad en el Servicio de Dermatología del Hospital Manuel Gea González. Se revisaron los archivos de esta institución y se seleccionaron los casos diagnosticados como HME. Se encontraron 9 casos. La mayoría de los pacientes fueron menores de…
A Synopsis of the Genus Stipa (Poaceae) in Middle Asia, Including a Key to Species Identification, an Annotated Checklist, and Phytogeographic Analys…
2020
The genus Stipa L. comprises over 150 species, all native to the Old World, where they grow in warm temperate regions throughout Europe, Asia, and North Africa. It is one of the largest genera in the family Poaceae in Middle Asia, where one of its diversity hotspots is located. However, identification of Middle Asian Stipa species is difficult because of the lack of new, comprehensive taxonomic studies including all of the species recorded in the region. We present a critical review of the Mid-Asian representatives of Stipa, together with an identification key and taxonomic listing. We relied on both published and unpublished information for the taxa involved, many of which are poorly known…
Listado taxonómico comentado de los Capitélidos (Annelida, Polychaeta) de la península Iberica, islas Chafarinas, Baleares y Canarias
2013
[EN] The present annotated checklist has been elaborated after revision of preserved materials (from the Museo Nacional de Ciencias Naturales, Madrid and the reference collection of the Marine Biology Laboratory of the University of Valencia) and published literature related to capitellids from the Iberian Peninsula, Chafarinas, Balearic and Canary Islands. Twenty-four species and subspecies belonging to thirteen genera are recognized as valid taxa. With this checklist we include some taxonomic details and information on distribution at both global and regional levels. This work includes the setal formula and diagrammatic representation of capitellid taxa treated in this study.
Joint Border of Ukraine and the European Union: Political and Legal Aspects of Cooperation in the Field of Integrated Border Management
2020
W artykule przeanalizowano polityczne i prawne aspekty oraz dynamikę stosunków Ukrainy z UE i jej państwami członkowskimi w zakresie zintegrowanego zarządzania granicami w celu usprawnienia współpracy międzyagencyjnej i międzynarodowej, ustanowienia wspólnej kontroli celnej i przejść granicznych, organizacji wspólnych patroli, zwiększenia bezpieczeństwa i otwartości granic państwowych oraz poprawy ich funkcji integracyjnej. Zbadano zagadnienia związane ze stworzeniem i modernizacją przejść granicznych, wprowadzaniem europejskich standardów ochrony granic, kontroli celnej i innych rodzajów kontroli na granicy państwowej Ukrainy i krajów UE. Zarysowano perspektywy przystąpienia Ukrainy do sys…
Mikołaj Rej's opinions about the Italian fashion for residential developments in Poland
2020
U progu światopoglądowych przemian Renesansu włoskiego rozpowszechnił się w XVI-wiecznej Polsce nowy model życia elit intelektualnych. Obszarem niezwykłej konkretyzacji tych ideowych metamorfoz stały się osiągnięcia architektoniczne. Willa podmiejska urosła do roli symbolu. Modny typ budowli znalazł w Polsce podatny grunt do rozwoju, gdzie szczególne nasilenie ruchu willowego widoczne było w najbliższych okolicach Krakowa. Świadectwo tego architektonicznego odrodzenia odnotował także Mikołaj Rej, zarówno bystry świadek, jak i komentator swojej epoki. Zapewne bardzo uważnie obserwował on ten ożywiony ruch w budownictwie oraz innych rzemiosłach, czemu dał wyraz w Źwierciadle... Pisarz starał …
Loneliness Among Older Home-Dwelling Persons: A Challenge for Home Care Nurses.
2021
Solveig Tomstad, Kari Sundsli, Hans Inge Sævareid, Ulrika Söderhamn Centre for Caring Research, Faculty of Health and Sport Sciences, University of Agder, Grimstad, NorwayCorrespondence: Solveig TomstadFaculty of Health and Sport Sciences, University of Agder, Kristiansand, 4604, NorwayEmail solveig.t.tomstad@uia.noAim: To explore how nurses working in the home care service sector perceived the loneliness experienced by older people living at home, and how they met these lonely individuals’ needs.Background: Loneliness is a well-known phenomenon among groups of older home-dwelling people and has been shown to be a health-related problem. Health care professional…
First-Line Treatments for Extensive-Stage Small-Cell Lung Cancer With Immune Checkpoint Inhibitors Plus Chemotherapy: A Network Meta-Analysis and Cos…
2022
BackgroundImmune checkpoint inhibitors (ICIs) plus chemotherapy were unlikely to be considered cost-effective compared with chemotherapy as the first-line treatment of patients with extensive-stage small-cell lung cancer (ES-SCLC) in China due to its high costs. However, the cost-effectiveness of the comparison between the regimens of ICIs plus chemotherapy were remained unclear yet. The aim of this study was to evaluate the efficacy and cost-effectiveness of ICIs plus chemotherapy as the first-line treatment for ES-SCLC from the perspective of the Chinese healthcare system.MethodsA network meta-analysis (NMA) was conducted to indirect compare the clinical benefits between the ICIs plus che…