Search results for "HECK"
showing 10 items of 682 documents
PD-1/PD-L1 immune-checkpoint blockade induces immune effector cell modulation in metastatic non-small cell lung cancer patients: A single-cell flow c…
2022
Peripheral immune-checkpoint blockade with mAbs to programmed cell death receptor-1 (PD-1) (either nivolumab or pembrolizumab) or PD-Ligand-1 (PD-L1) (atezolizumab, durvalumab, or avelumab) alone or in combination with doublet chemotherapy represents an expanding treatment strategy for metastatic non-small cell lung cancer (mNSCLC) patients. This strategy lays on the capability of these mAbs to rescue tumor-specific cytotoxic T lymphocytes (CTLs) inactivated throughout PD-1 binding to PD-L1/2 in the tumor sites. This inhibitory interactive pathway is a physiological mechanism of prevention against dangerous overreactions and autoimmunity in case of prolonged and/or repeated CTL response to …
Moving Immune Checkpoint Inhibitors to Early Non-Small Cell Lung Cancer: A Narrative Review
2022
Simple Summary Moving from the achievements of immune checkpoint inhibitors in metastatic lung cancer, the great promise of immunotherapy in resectable early-stage is to make a disease, often lethal until now for frequent post-surgery relapses, more curable. This review focuses on role of immunotherapy in early-stage non-small cell lung cancer. We summarize biological rationale, findings from clinical trials of adjuvant and neoadjuvant immune checkpoint inhibitors, questions about biomarkers and choice of endpoints, aiming to provide up-to-date information useful for clinical decision making. Lung cancer is the leading cause of cancer-related death worldwide. Since prognosis of early-stage …
Incidence of mucositis during therapy with PD1-PDL1 type immune checkpoint inhibitors
2020
The Application of CRISPR/Cas9 Technology for Cancer Immunotherapy: Current Status and Problems
2022
Cancer is one of the main causes of disease-related deaths in the world. Although cancer treatment strategies have been improved in recent years, the survival time of cancer patients is still far from satisfied. Cancer immunotherapy, such as Oncolytic virotherapy, Immune checkpoints inhibition, Chimeric antigen receptor T (CAR-T) cell therapy, Chimeric antigen receptor natural killer (CAR-NK) cell therapy and macrophages genomic modification, has emerged as an effective therapeutic strategy for different kinds of cancer. However, many patients do not respond to the cancer immunotherapy which warrants further investigation to optimize this strategy. The clustered regularly interspaced short …
Classification of current anticancer immunotherapies.
2014
© 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Kestävyys- ja teholajiurheilijoiden kuormittuminen ja kuormittumisen seuranta lyhyellä aikavälillä
2018
Nikola-Määttä, Sanna (2018). Kestävyys- ja teholajiurheilijoiden kuormittumisen seuranta lyhyellä aikavälillä. Liikuntatieteellinen tiedekunta, Jyväskylän yliopisto, Liikuntafysiologian Pro-Gradu -tutkielma, 69 s. Kuormittumisen seuranta on oleellinen osa urheilijoiden harjoittelua ja valmennusta. Ylikuormitus on yleisempää yksilölajeissa kuin joukkuelajeissa. Kestävyyslajien edustajilla on todettu olevan suurempi riski sairastua ylikuormitustilaan. Lisäksi ylikuormittumista on enemmän aikuisilla miehillä kuin naisilla, mutta toisaalta nuorilla tyttöurheilijoilla on havaittu enemmän ylikuormittumista kuin poikaurheilijoilla. Tässä Pro gradu -työssä on tarkasteltu Vuokatti-Ruka Urheiluakatem…
Conexión de la ruta de proteinquinasa C con la respuesta a estrés genotóxico
2022
El mantenimiento de la integridad genómica es un aspecto crucial para la supervivencia celular. El checkpoint de integridad del DNA es el mecanismo de vigilancia encargado de detectar la presencia de daño en el DNA y poner en marcha una respuesta celular para mantener la estabilidad genómica. Los componentes centrales del checkpoint son las quinasas sensoras ATM y ATR (Tel1 y Mec1 en S. cerevisiae) y CHK1 Y CHK2 (Chk1 y Rad53 en levadura). La correcta activación del checkpoint depende de la actividad de proteína quinasa C (PKC), tanto en células de levadura como de mamíferos. En este trabajo se ha profundizado en la relación entre PKC y la maquinaria del checkpoint de integridad del DNA, as…
Rhetorical strategies of counter-journalism:How American YouTubers are challenging dominant media election narratives
2021
Standardy i praktyki dziennikarskie, które mają służyć demokratycznej deliberacji w erze cyfryzacji są stałym przedmiotem analiz. Stany Zjednoczone to kraj o długiej tradycji dziennikarstwa śledczego, które wielokrotnie odkrywało szkodliwe działania polityków i biznesmenów. W dobie dominacji nowych mediów, do tych praktyk dziennikarskich dołączyła jeszcze konieczność sprawdzania faktów i kontrowania narracji i twierdzeń propagowanych w upolitycznionych mediach komercyjnych. Niniejszy artykuł poświęcony jest retoryce nowego gatunku kontrdziennikarstwa cyfrowego. Przedstawia wyniki analizy strategii retorycznych i erystycznych zidentyfikowanych w krótkich filmach rozpowszechnianych przez popu…
Trial Watch: Adoptively transferred cells for anticancer immunotherapy
2017
IF 7.719; International audience; Immunotherapies aimed at strengthening immune effector responses against malignant cells are growing at exponential rates. Alongside, the impressive benefits obtained by patients with advanced melanoma who received adoptively transferred tumor-infiltrating lymphocytes (TILs) have encouraged the scientific community to pursue adoptive cell transfer (ACT)-based immunotherapy. ACT involves autologous or allogenic effector lymphocytes that are generally obtained from the peripheral blood or resected tumors, expanded and activated ex vivo, and administered to lymphodepleted patients. ACT may be optionally associated with chemo- and/or immunotherapeutics, with th…
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models.
2018
Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma. In this paper, we describe a novel model faithfully recapitulating some key human GBM characteristics, including low mutational load, a factor reported as a prognostic indicator of ICB response. Consistent with this observation, SB28 is completely resistant to ICB, contrasting with treatment sensitivity of the more highly mutated GL261. Moreover, SB28 shows features of a poorly immunogenic tumor, with low MHC-I expression and modest CD8(+) T-cell infiltration, suggest…