Search results for "HHI"

Founder effects drive the genetic structure of passively dispersed aquatic invertebrates

2018

Populations of passively dispersed organisms in continental aquatic habitats typically show high levels of neutral genetic differentiation, despite their high dispersal capabilities. Several evolutionary factors, including founder events and local adaptation, and life cycle features such as high population growth rates and the presence of propagule banks, have been proposed to be responsible for this paradox. Here, we have modeled the colonization process in these organisms to assess the impact of migration rate, growth rate, population size, local adaptation and life-cycle features on their population genetic structure. Our simulation results show that the strongest effect on population st…

Variants associated with HHIP expression have sex-differential effects on lung function

2021

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P<5x10-8) interactions with sex …

SUITE D'AUTORE: ARCHITETTURA, DESIGN E TECNOLOGIA PER UNA MODERNA CULTURA DELL'OSPITALITA'

2008

Per comprendere a fondo l’insieme delle modificazioni che hanno interessato il territorio antropizzato nel corso dei secoli, occorre anche valutare quelle specifiche architetture che sono destinate all’ospitalità; in particolare occorre considerare le loro peculiarità concettuali, spaziali, funzionali e tecnologiche, che si sono lentamente modificate per garantire il raggiungimento di un alto livello qualitativo per l’accoglienza. Nel presente volume, l’esigenza di indagare nel campo dell’accoglienza e di ritrovare quei caratteri della ricerca scientifica che ne definiscono la storia, la tecnica, i materiali e non di meno le emozioni, diviene l’obiettivo che l’Autore vuole raggiungere. Il v…

A genome-wide view of Caenorhabditis elegans base-substitution mutation processes

2009

Knowledge of mutation processes is central to understanding virtually all evolutionary phenomena and the underlying nature of genetic disorders and cancers. However, the limitations of standard molecular mutation detection methods have historically precluded a genome-wide understanding of mutation rates and spectra in the nuclear genomes of multicellular organisms. We applied two high-throughput DNA sequencing technologies to identify and characterize hundreds of spontaneously arising base-substitution mutations in 10 Caenorhabditis elegans mutation-accumulation (MA)-line nuclear genomes. C. elegans mutation rate estimates were similar to previous calculations based on smaller numbers of m…

Physics and metaphysics in the Hitchhiker Series (1979-1992) by Douglas Adams

2006

Embodied responses to musical experience detected by human bio-feedback brain features in a geminoid augmented architecture

2018

Abstract This paper presents the conceptual framework for a study of musical experience and the associated architecture centred on Human-Humanoid Interaction (HHI). On the grounds of the theoretical and experimental literature on the biological foundation of music, the grammar of music perception and the perception and feeling of emotions in music hearing, we argue that music cognition is specific and that it is realized by a cognitive capacity for music that consists of conceptual and affective constituents. We discuss the relationship between such constituents that enables understanding, that is extracting meaning from music at the different levels of the organization of sounds that are f…

Human-to-human interfaces: emerging trends and challenges

2011

We present a new research domain, human-to-human interaction (HHI) that describes how today's human interaction is largely indirect and mediated by a wide variety of technologies and devices. We show how this new and exciting field of design originates from the convergence of a few well-established research areas, such as traditional graphical user interfaces (GUIs), tangible user interfaces (TUIs), touchless gesture user interfaces (TGUIs), voice user interfaces (VUIs), and brain computer interfaces (BCIs). We analyse and describe current research in those areas and offer a first-hand view and presentation of its salient aspects for the human-to human interaction domain.

Hypofractionnated radiotherapy for elderly patients with prostate cancer

2018

Radiation therapy technique and schedules could be adapted to patient's age because of a natural history of prostate cancer perceived as different, taking into account the comorbidities of patients but also a particular tolerance of elderly subjects. Thus, in localized prostate cancer, evaluation of associated diseases is essential before considering a treatment that will be of interest only if the life expectancy is greater than 10 years. When a curative approach is decided, radiotherapy holds a place of choice. Due to the recent results of randomized studies evaluating moderate hypofractionnated radiotherapy, showing a carcinological equivalence compared to a standard fractionation, this …

Pointe de Bretagne = Penn Breizh

1996

International audience

Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved]

2020

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P<5x10-8) interactions with sex on …