Search results for "HIF"
showing 10 items of 1515 documents
A Holistic Approach to Comprehending the Complexity of the Post-growth Era: The Emerging Profile
2015
The goal of this study is to investigate the problems caused by the rapid growth of the global economy, coupled with high population growth and the excessive exploitation of natural resources. The global economy will not be able to maintain its current speed of growth in the long term, so a paradigm shift in production and consumption is necessary, if the collapse of ecosystems and the concurrent depletion of natural resources are to be avoided. This is the reason why capitalism needs to take a turn towards a sustainable and naturally harmonized development model.
Experimental generation of optical flaticon pulses
2013
International audience; We experimentally investigate the nonlinear reshaping of a continuous wave which leads to chirp-free and flat-top intense pulses or flaticons exhibiting strong temporal oscillations at their edges and a stable self-similar expansion upon propagation of their central region. This study was performed in the normal dispersion regime of a non-zero dispersion-shifted fiber and involved a sinusoidal phase modulation of the continuous wave. Our fiber optics experiment is analogous to considering the collision between oppositely directed currents near the beach, and it may open the way to new investigations in the field of hydrodynamics.
Learning from Social Collaboration
2017
This chapter focuses on the challenge of evaluating game-based learning. It argues that linking game-based learning with the characteristics of a specific game or game-produced engagement is challenging. It further proposes a framework in which the game-based learning process is approached by considering (business) simulation games as Computer-Supported Collaborative Learning (CSCL) environments and presents an approach on how learning can be approached and evaluated from this perspective. In addition, it highlights how simulation game mechanics appears to be a potential way to promote learners' socio-emotional processes and give rise to social interaction and to structure collaboration amo…
Synthesis and characterization of vanadyl(IV) complexes of Schiff bases derived from anthranilic acid and salicylaldehyde (or its derivatives) or ace…
1997
Anhydrous, dimeric vanadyl(IV) complexes of Schiff bases derived from [1+1] condensation of salicylaldehyde (or its derivatives) and anthranilic acid, have been synthesized from CH3CN and were characterized by elemental analysis, FTIR, EPR, absorption, TGA, cyclic voltammetry and room temperature magnetic susceptibility measurements. These complexes were found to be oxidized by air in polar solvents like MeOH and DMF to V-V products. The E(1/2) values were found to be around 660 mV indicating that the carboxylate group favours vanadyl(IV) binding when compared to the alkoxo-bound vanadium complexes. Oxidative instability of these complexes are dependent on the substituent on the salicylalde…
Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences
2021
The specific recognition of AT-rich DNA sequences opens up the door to promising diagnostic and/or therapeutic strategies against gene-related diseases. Here, we demonstrate that amphiphilic PtII complexes of the type [Pt(dmba)(N∧N)]NO3 (dmba = N,N-dimethylbenzylamine-κN, κC; N∧N = dpq (3), dppz (4), and dppn (5)) recognize AT-rich oligonucleotides over other types of DNA, RNA, and model proteins. The crystal structure of 4 shows the presence of significant π-stacking interactions and a distorted coordination sphere of the d8 PtII atom. Complex 5, containing the largest π-conjugated ligand, forms supramolecular assemblies at high concentrations under aqueous environment. However, its aggreg…
Photomagnetic properties of an Iron(II) low-spin complex with an unusually long-lived metastable LIESST state
2007
A comprehensive study of the photomagnetic behavior of the [Fe(L222N5)(CN)2].H2O complex has been carried out. This complex is characterized by a low-spin (LS) iron(II)-metal center up to 400 K and exhibits at 10 K the well-known Light-Induced Excited Spin State Trapping (LIESST) effect. The critical LIESST temperature (T(LIESST)) has been measured to be 105 K. The kinetics of the transition from the metastable high-spin (HS) state to the low-spin state have been determined and used for reproducing the experimental T(LIESST) curve. This study represents a second example of a fully low-spin iron(II)-metal complex up to 400 K, which can be photoexcited at low temperature with an atypical long…
A conceptual framework for the neurobiological study of resilience.
2014
AbstractThe well-replicated observation that many people maintain mental health despite exposure to severe psychological or physical adversity has ignited interest in the mechanisms that protect against stress-related mental illness. Focusing on resilience rather than pathophysiology in many ways represents a paradigm shift in clinical-psychological and psychiatric research that has great potential for the development of new prevention and treatment strategies. More recently, research into resilience also arrived in the neurobiological community, posing nontrivial questions about ecological validity and translatability. Drawing on concepts and findings from transdiagnostic psychiatry, emoti…
Mutation Analysis of Core Binding Factor A1 in Patients with Cleidocranial Dysplasia
1999
SummaryCleidocranial dysplasia (CCD) is a dominantly inherited disorder characterized by patent fontanelles, wide cranial sutures, hypoplasia of clavicles, short stature, supernumerary teeth, and other skeletal anomalies. We recently demonstrated that mutations in the transcription factor CBFA1, on chromosome 6p21, are associated with CCD. We have now analyzed the CBFA1 gene in 42 unrelated patients with CCD. In 18 patients, mutations were detected in the coding region of the CBFA1 gene, including 8 frameshift, 2 nonsense, and 9 missense mutations, as well as 2 novel polymorphisms. A cluster of missense mutations at arginine 225 (R225) identifies this residue as crucial for CBFA1 function. …
The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: Measuring D_A and H at z=0.57 from the Baryon Acoustic Peak in th…
2014
We present measurements of the angular diameter distance to and Hubble parameter at z = 0.57 from the measurement of the baryon acoustic peak in the correlation of galaxies from the Sloan Digital Sky Survey III Baryon Oscillation Spectroscopic Survey. Our analysis is based on a sample from Data Release 9 of 264 283 galaxies over 3275 square degrees in the redshift range 0.43 z DA(0.57) = 1408 ± 45 Mpc and H(0.57) = 92.9 ± 7.8 km s-1 Mpc-1 for our fiducial value of the sound horizon. These results from the anisotropic fitting are fully consistent with the analysis of the spherically averaged acoustic peak position presented in Anderson et al. Our distance measurements are a close match to th…
Neutral hydrogen in galaxy clusters: impact of AGN feedback and implications for intensity mapping
2015
By means of zoom-in hydrodynamic simulations we quantify the amount of neutral hydrogen (HI) hosted by groups and clusters of galaxies. Our simulations, which are based on an improved formulation of smoothed particle hydrodynamics (SPH), include radiative cooling, star formation, metal enrichment and supernova feedback, and can be split in two different groups, depending on whether feedback from active galactic nuclei (AGN) is turned on or off. Simulations are analyzed to account for HI self-shielding and the presence of molecular hydrogen. We find that the mass in neutral hydrogen of dark matter halos monotonically increases with the halo mass and can be well described by a power-law of th…