Search results for "HIF"

1H,13C and15N NMR chemical shifts of substituted pyrazolo[1,5-a]pyrimidines

2002

Hydrogen bond mediated intermolecular magnetic coupling in mononuclear high spin iron(iii) Schiff base complexes: synthesis, structure and magnetic s…

2020

The crystal structure and magnetic properties of two mononuclear iron(III) Schiff base complexes, [FeL1(NCS)2] (1), HL1 = 2-[1-[[2-[(2-aminoethyl)amino]ethyl]imino]ethyl]phenol and [FeL2(N3)Cl] (2), HL2 = 2-(-1-(2-(2-aminoethylamino)ethylimino)ethyl)-4-methylphenol are reported. Each complex contains a Fe(III) ion surrounded by a N3O Schiff base ligand and two NCS− ligands (in 1) or one N3− and one Cl− ligands (in 2). The magnetic properties can be well reproduced with zero field splittings in the high spin S = 5/2 Fe(III) ions and weak intermolecular Fe–Fe interactions mediated by hydrogen bonds. This intermolecular antiferromagnetic interaction has been validated by using DFT calculations…

The dianion of [2.2.2]paracyclophene; a 20 π-perimeter species?

1986

Abstract A new synthesis of [2.2.2]paracyclophene (1) is presented on reduction,(1) forms a stable dianion which is neither diatropic. nor paratropic. The apparent high symmetry of the dianion and the observed NMR chemical shifts are best explained by a rapid interconversion of a series of C 2-conformers.

E-wave and heart rate responses during anticipation of nonmotor events.

1994

This study concentrated on three main questions: 1) can anticipatory late negative shift (expectancy wave, E-wave) be elicited in nonmotor S1-S2 paradigm, 2) is it sensitive to variation of emotional aspects of the task and 3) is there a connection between heart rate (HR) responses and E-wave. S1 was a letter row that was replaced tachistoscopically by another letter row (S2). The task of the subjects (n = 12) was to detect if the critical aspects of S2 were similar to S1. After their delayed response they received feedback of their performance. The emotional aspects of the task were varied by presenting aversive noise bursts at the end of the feedback period either always, contingently to …

Valencia’s ‘Men for Equality’ movement. An assessment of some of its protagonists

2019

The Men for Equality movement [El movimiento de hombres por la igualdad - HPLI], although a fairly recent phenomenon, already has a forty year track record in Valencia. The movement has had its high and low points. After the trail blazed by protagonists in Valencian society, a period of consolidation followed in which those who came after them kept the movement going. A qualitative study carried out by the Department of Sociology and Social Anthropology records the impressions of those men who kept the movement alive between 1975 and 2018 despite the odds at the outset. These voices are analysed within frameworks for interpreting movements. As a social movement, Men for Equality developed n…

Negotiating the Terminological Borders of ‘Language Mediation’ in English and Italian. A Discussion on the Repercussions of Terminology on the Practi…

2015

Linguistic and cultural mediation has been playing an increasingly important role in contemporary society as a result of the intensification of international exchanges and migration flows; however, the definitions that have been given of it are still rather vague and inconsistent. In some cases linguistic and cultural mediation is seen as a broad superordinate category, comprising a range of different interlinguistic and intercultural activities serving the purpose of facilitating communication across languages, cultures and societies in various areas of civil society: industry, business, trade, law, literature, academia, institutions, public services, etc. In other cases, instead, the defi…

The electronic spectra of 2-(2′-hydroxybenzoyl)pyrrole and 2-(2′-methoxybenzoyl)pyrrole: a theoretical study

2005

The gas-phase electronic spectra of 2-(2 0 -hydroxybenzoyl)pyrrole and 2-(2 0 -methoxybenzoyl)pyrrole have been determined using multiconfigurational perturbation theory (CASPT2). Solvatochromic spectral shifts for these molecules have been measured in cyclohexane and methanol and the electrostatic components of these shifts have been estimated using the vertical electrostatic model (VEM 4.2) developed for the configuration interaction with single excitations model implemented with the intermediate neglect of differential overlap Hamiltonian (CIS/INDO/ S2). Comparison between theory and experiment and an interpretation of the main spectral differences between the two substituted pyrroles an…

Two Remarkably Luminous Galaxy Candidates at z ≈ 10-12 Revealed by JWST

2022

The first few 100 Myr at z > 10 mark the last major uncharted epoch in the history of the universe, where only a single galaxy (GN-z11 at z ≈ 11) is currently spectroscopically confirmed. Here we present a search for luminous z > 10 galaxies with JWST/NIRCam photometry spanning ≈1–5 μm and covering 49 arcmin2 from the public JWST Early Release Science programs (CEERS and GLASS). Our most secure candidates are two MUV ≈ −21 systems: GLASS-z12 and GLASS-z10. These galaxies display abrupt ≳1.8 mag breaks in their spectral energy distributions (SEDs), consistent with complete absorption of flux bluewards of Lyα that is redshifted to =+z12.40.3 0.1and=+z10.40.5 0.4. Lower redshift interlopers su…

Mutagenicity test system based on a reporter gene assay for short-term detection of mutagens (MutaGen assay).

2003

Abstract The construction of a bacterial mutation assay system detecting reversions of base substitutions and frameshifts in tetracycline (tet) and ampicillin resistance genes located on low copy plasmids is described. Frameshift mutations were introduced into repetitive GC-sequences and G-repeats known to be mutagenic hot-spots. Base pair substitutions were inserted in or around the active site of the ampicillinase gene thus generating reversibility of the ampicilline sensitivity. The plasmids carry genes to enable sensitive, fast and specific detection of mutagens in bacteria. MucAB was cloned into the test plasmid to enhance error-prone DNA-repair. The conventional reversion principle ha…

A frame shift mutation in a hot spot region of the nuclear autoantigen La (SS-B).

1996

A hot spot region was identified in the exon 7 of the nuclear autoantigen La (SS-B). Two La cDNAs were identified which contained a frame shift mutation in the hot spot region. One La cDNA was isolated from a cDNA library made from peripheral blood lymphocytes of an autoimmune patient with primary Sjogren's Syndrome, the other La cDNA was isolated from a human liver cDNA library. The patient's La cDNA had a deletion and the liver La cDNA had an insert of an (A)-residue at the same position. Inserts of 4, 16 and 24 more or less homogeneous (A)-residues were found at the same site in the three La retropseudogenes. The hot spot region located in one of the major autoepitope regions of the La a…