Search results for "HIF"
showing 10 items of 1515 documents
Vacuolated PAS-Positive Lymphocytes on Blood Smear: An Easy Screening Tool and a Possible Biomarker for Monitoring Therapeutic Responses in Late Onse…
2018
Background: Primary aim was to investigate the diagnostic value of PAS-positive vacuolated lymphocytes on blood smear in Late Onset Pompe Disease (LOPD) patients and, secondly, to evaluate its potential utility in monitoring treatment effects.Methods: We examined blood smear of 26 LOPD patients. We evaluated 10 treated and 16 untreated LOPD patients. Among the latter group, 7 patients later initiated ERT and were tested again 6 months after start. Blood smear was also sampled from 82 controls and 19 patients with other muscle glycogenoses (MGSDs). PAS staining was used to evaluate: (1) presence of lymphocytes with glycogen-filled vacuoles, (2) quantification of vacuolated lymphocytes.Result…
Thermostabilization of BSA in TMAO Water Mixtures by Infrared Spectroscopy
2019
Background:Trimethylamine-N-Oxide (TMAO) is a small organic molecule derived from the metabolism of L-carnitine and choline after ingestion of animal food. TMAO has many functions such as electron acceptor, an osmolyte, stabilizer of macromolecules folding. It seems that TMAO plays an important role in nature but, in humans, it is a remnant of the evolution of the osmolyte system.Objective:The present paper is addressed on the study of thermal stability of hydrated Bovine Serum Albumins (BSA) in the presence of water and TMAO water solution by means of InfraRed spectroscopy. In particular, this work has investigated the protein amide I spectral regions, which is sensitive to protein seconda…
Dispersion from Cα or NH: 4D experiments for backbone resonance assignment of intrinsically disordered proteins
2020
AbstractResonance assignment of intrinsically disordered proteins is remarkably challenging due to scant chemical shift dispersion arising from conformational heterogeneity. The challenge is even greater if repeating segments are present in the amino acid sequence. To forward unambiguous resonance assignment of intrinsically disordered proteins, we present iHACANCO, HACACON and (HACA)CONCAHA, three Hα-detected 4D experiments with Cα as an additional dimension. In addition, we present (HACA)CON(CA)NH and (HACA)N(CA)CONH, new 4D Hα-start, HN-detect experiments which have two NH dimensions to enhance peak dispersion in a sequential walk through C′, NH and HN, and provide more accurate NH/HN ch…
Language shifts in the language biographies of immigrants from Upper Silesia residing in Germany
2020
Abstract The main objective of the article is to illustrate how language ideologies and language management at the macro-level (state language policy), micro-level (in families) and meso-level (local communities) influence language change and the conceptualization of multilingualism of immigrants from Upper Silesia residing in Germany. Language biographies of persons from Silesia demonstrate the significant influence of historical and political events on sociolinguistic processes. Original fragments of biographical interviews of the people surveyed constitute an integral part of the text.
Decision support system to design feasible high-frequency Motorways of the Sea: A new perspective for public commitment
2016
ABSTRACTThe implementation of Motorways of the Sea (MoS) within the framework of European Union aid programs experiences a period of relative stagnation. This article analyzes the suitability of current short-term nonrepayable subsidy policy and develops a decision support system (DSS) that allows a medium- and long-term feasibility analysis of MoS proposals. One significant conclusion drawn from the application of the proposed DSS to a prototypical high-frequency MoS provides that the period of initial losses prior to achievement of both modal shift and accounting profits might last 10 years. Moreover, the entire duration of the period that includes prior objectives as well as the recoveri…
Language Policy and Ethnic Tensions in Quebec and Latvia
2004
Introduction Concern for the French language in Quebec in the 1960s and 1970s and the Latvian language in the then Soviet Union in the late 1980s and in the new Latvian state in the 1990s were ignited by some of the same demographic and assimilative forces in the two societies. Both Quebec and Latvia had lost their independence to larger powers. The birth rate and population declined abruptly in the two subnations. Schools in English (in Quebec) and Russian (in Latvia) attracted most immigrants. The elites were disproportionately drawn from outside the majority ethnic groups. To counter these trends, language policies were drafted, restricting access to English and Russian languages in scho…
Does Patriotic Vigilance Make Any Sense in the Transnational Arena? A Cosmopolitan Alternative to the Globalization Paradox
2017
We address the issue of the relevance in the transnational arena of the concept of patriotic vigilance, as expressed by French Minister Arnaud Montebourg in 2014. Firstly, we examine the globalization paradox with its underpinnings in the literature and its illustration through the recent Alstom saga. Secondly, we review the idea of a paradigm shift in world monetary affairs signaled by the recent crisis. Finally, drawing on Kant’s ideas on cosmopolitism, we sketch out an alternative to the globalization paradox.
Nonlinear femtosecond pulse propagation in an all-solid photonic bandgap fiber
2009
Nonlinear femtosecond pulse propagation in an all-solid photonic bandgap fiber is experimentally and numerically investigated. Guiding light in such fiber occurs via two mechanisms: photonic bandgap in the central silica core or total internal reflection in the germanium doped inclusions. By properly combining spectral filtering, dispersion tailoring and pump coupling into the fiber modes, we experimentally demonstrate efficient supercontinuum generation with controllable spectral bandwidth.
The Loss of Grammatical Gender and Case Features Between Old and Early Middle English: Its Impact on Simple Demonstratives and Topic Shift
2017
AbstractIn this paper we examine the relation between the loss of formal gender and Case features on simple demonstratives and the topic shifting property they manifest. The examination period spans between Old English and Early Middle English. While we argue that this loss has important discourse-pragmatic and derivational effects on demonstratives, we also employ the Strong Minimalist Hypothesis approach (Chomsky 2001) and feature valuation, as defined in Pesetsky & Torrego (2007), to display how their syntactic computation and pragmatic properties have come about. To account for the above innovations yielding the Early Middle Englishϸe(‘the’), we first discuss the formal properties o…
Rho resonance, timelike pion form factor, and implications for lattice studies of the hadronic vacuum polarization
2020
We study isospin-1 P-wave ππ scattering in lattice QCD with two flavors of O(a) improved Wilson fermions. For pion masses ranging from mπ=265 MeV to mπ=437 MeV, we determine the energy spectrum in the center-of-mass frame and in three moving frames. We obtain the scattering phase shifts using Lüscher’s finite-volume quantization condition. Fitting the dependence of the phase shifts on the scattering momentum to a Breit-Wigner form allows us to determine the corresponding ρ mass mρ and gρππ coupling. By combining the scattering phase shifts with the decay matrix element of the vector current, we calculate the timelike pion form factor, Fπ, and compare the results to the Gounaris-Sakurai repr…