Search results for "HIV-1"
showing 10 items of 177 documents
Lipid profile during pregnancy in HIV-infected women
2006
Purpose: We investigated the evolution of serum lipid levels in HIV-infected pregnant women and the potential effect of antiretroviral treatment during pregnancy using data from a national surveillance study. Method: Fasting lipid measurements collected during routine care in pregnancy were used, analyzing longitudinal changes and differences in lipid values at each trimester by protease inhibitors (Pls) and stavudine use. Multivariate analyses were used to control for simultaneous factors potentially leading to hyperlipidemia. Study population included 248 women. Results: Lipid values increased progressively and significantly during pregnancy: mean increases between the first and third tri…
De novo drug design and synthesis of new HIV-1 NNRTIs
2002
Design and synthesis of new HIV-1 NNRTIs
2003
Design and synthesis of new 2,3-diaryl-1,3-thiazolidin-4-one HIV-1 RT-inhibitors.
2002
Computational methodologies in the discovery of inhibitors of HIV-1
2009
Ricerca di mutazioni primarie agli inibitori della fusione in soggetti con infezione da virus dell’immunodeficienza umana (HIV-1)
2008
“Evidence of HIV-1 second-generation recombinant strains (SGRs) in Sicily: sequence analysis of gag, pol, and env genes.”
2007
Molecular epidemiology of HIV type 1 (HIV-1) non-B subtypes in SIcily
2004
Immune activation promotes evolutionary conservation of T-cell epitopes in HIV-1.
2013
The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (TH cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient l…