Search results for "HIV"

showing 10 items of 1527 documents

Interference with purinergic signalling

2016

Objective: The association of abacavir (ABC), a guanosine analogue, with cardiovascular toxicity is a long-lasting matter of controversy engendered by the lack of a mechanism of action. Clinical data point to an acute mechanism of vascular inflammation. Previous studies have shown that ABC induces leukocyte-endothelial cell interactions, an indicator of vascular inflammation. These effects are reproduced by another purine analogue, didanosine, but not by pyrimidine or acyclic nucleotide analogues, hinting at an interference with the purinergic system. The aim of the present study was to assess the role of ATP-receptors in leukocyte accumulation induced by ABC. Design and methods: Clinical c…

Male0301 basic medicineIntravital MicroscopyAnti-HIV AgentsImmunologyMacrophage-1 AntigenLeukocyte RollingPharmacologyleukocyte-endothelium interactionsP2X7 receptors03 medical and health sciences0302 clinical medicineIn vivoCell AdhesionLeukocytesmedicineAnimalsHumansImmunology and Allergypurinergic030212 general & internal medicineCell adhesionReceptorCells CulturedMice KnockoutChemistryabacavirPurinergic receptorEndothelial CellsHIVPurinergic signallingDideoxynucleosidescardiovascular diseasesMice Inbred C57BLATP030104 developmental biologyInfectious DiseasesMechanism of actionKnockout mouseReceptors Purinergic P2X7medicine.symptomAIDS
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Transmission dynamics of HIV-1 subtype B in the Basque Country, Spain

2016

This work was aimed to study the HIV-1 subtype B epidemics in the Basque Country, Spain. 1727 HIV-1 subtype B sequences comprising protease and reverse transcriptase (PR/RT) coding regions, sampled between 2001 and 2008, were analyzed. 156 transmission clusters were detected by means of phylogenetic analyses. Most of them comprised less than 4 individuals and, in total, they included 441 patients. Six clusters comprised 10 or more patients and were further analyzed in order to study their origin and diversification. Four clusters included men who had unprotected homosexual sex (MSM), one group was formed by intravenous drug users (IDUs), and another included both IDUs and people infected th…

Male0301 basic medicineMicrobiology (medical)Time FactorsGenotypePopulationHuman immunodeficiency virus (HIV)HIV InfectionsBiologymedicine.disease_causeMicrobiologyVirusDrug Users03 medical and health sciencesHIV ProteaseDrug Resistance ViralGeneticsmedicineAntiretroviral treatmentHumansProtease inhibitor (pharmacology)Homosexuality MaleeducationMolecular BiologyPhylogenyEcology Evolution Behavior and Systematicseducation.field_of_studyIntravenous drugSequence Analysis RNATransmission (medicine)virus diseases030112 virologyVirologyHIV Reverse TranscriptaseReverse transcriptaseVirus030104 developmental biologyInfectious DiseasesSpainMutationInfeccióHIV-1Infection, Genetics and Evolution
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Human Immunodeficiency Virus Continuum of Care in 11 European Union Countries at the End of 2016 Overall and by Key Population: Have We Made Progress?

2020

Abstract Background High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed …

Male0301 basic medicinePsychological interventionHuman immunodeficiency virus (HIV)MedizinContinuum of care; Europe; HIV infection; Key population; Sex; Anti-Retroviral Agents; Continuity of Patient Care; European Union; HIV; Humans; Male; HIV InfectionsHIV InfectionsContinuum of care; Europe; HIV infection; Key population; Sexmedicine.disease_causekey population0302 clinical medicineContinuum of careHIV Infection030212 general & internal medicineMen having sex with menContinuum of caremedia_commoneducation.field_of_study[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologyTransmission (medicine)Continuity of Patient CareEuropeInfectious DiseasesAcademicSubjects/MED00290Anti-Retroviral AgentsHIV infection continuum of care sex key population EuropeSexMicrobiology (medical)PopulationSocio-culturale03 medical and health sciencesAcquired immunodeficiency syndrome (AIDS)SDG 3 - Good Health and Well-beingmedicinemedia_common.cataloged_instanceHumansEuropean UnionEuropean unioneducationPandemicsHIV infection ; continuum of care ; sex ; key population ; Europebusiness.industrySARS-CoV-2COVID-19HIVmedicine.diseaseHIV infectioncontinuum of care030112 virologyMajor Articles and CommentariesKey populationAnti-Retroviral Agentbusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyDemography
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Is physician assessment of alcohol consumption useful in predicting risk of severe liver disease among people with HIV and HIV/HCV co-infection?

2019

AbstractBackgroundAlcohol consumption is a known risk factor for liver disease in HIV-infected populations. Therefore, knowledge of alcohol consumption behaviour and risk of disease progression associated with hazardous drinking are important in the overall management of HIV disease. We aimed at assessing the usefulness of routine data collected on alcohol consumption in predicting risk of severe liver disease (SLD) among people living with HIV (PLWHIV) with or without hepatitis C infection seen for routine clinical care in Italy.MethodsWe included PLWHIV from two observational cohorts in Italy (ICONA and HepaICONA). Alcohol consumption was assessed by physician interview and categorized ac…

Male030508 substance abuseHIV InfectionsSeverity of Illness IndexCohort StudiesLiver disease0302 clinical medicineRisk FactorsEpidemiologyMedicineHIV InfectionAlcohol consumptionAlcohol consumption HIV-infected HIV/HCV co-infection Severe liver disease030212 general & internal medicineeducation.field_of_studyCoinfectionLiver Diseaselcsh:Public aspects of medicineLiver DiseasesHazard ratioHepatitis CMiddle AgedHepatitis CItalyalcohol consumption; HIV-infected; HIV/HCV co-infection; severe liver diseaseCoinfectionFemale0305 other medical scienceHumanCohort studyResearch ArticleAdultmedicine.medical_specialtyAlcohol DrinkingPopulationSevere liver diseaseHIV/HCV co-infectionNO03 medical and health sciencesEnvironmental healthHumansRisk factorAlcohol consumption; HIV-infected; HIV/HCV co-infection; Severe liver disease; Adult; Alcohol Drinking; Cohort Studies; Female; HIV Infections; Hepatitis C; Humans; Italy; Liver Diseases; Male; Middle Aged; Risk Factors; Severity of Illness Index; CoinfectioneducationHIV-infectedbusiness.industryRisk FactorPublic Health Environmental and Occupational Healthlcsh:RA1-1270medicine.diseaseCohort StudiebusinessBMC Public Health
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Serum Malondialdehyde in HIV Seropositive Children

1998

Human immunodeficiency virus (HIV) infection is associated with oxidative stress as it has been demonstrated in adult seropositive individuals. We show in this study that serum malondialdehyde (MDA) concentration of HIV infected children was significantly higher than in control children. Moreover, a statistically significant decreased serum antioxidant status was detected in HIV infected children when compared with controls. No correlation was found in HIV infected children between their clinical or immunological categories, CD4+ lymphocyte count or CD4+/CD8+ ratio, and MDA concentration or serum antioxidant status. Newborn from HIV seropositive mothers had also a higher MDA concentration i…

MaleAdolescentLymphocyteBirth weightCD4-CD8 RatioCD4-CD8 Ratiomedicine.disease_causeBiochemistryAntioxidantschemistry.chemical_compoundMalondialdehydePhysiology (medical)HIV SeropositivitymedicineHumansChildbusiness.industryInfant NewbornInfantGestational ageMalondialdehydePathophysiologyCD4 Lymphocyte CountOxidative Stressmedicine.anatomical_structurechemistryChild PreschoolCord bloodImmunologyFemalebusinessOxidative stressFree Radical Biology and Medicine
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Adolescents' knowledge and attitudes concerning HIV infection and HIV-infected persons: how a survey and focus group discussions are suited for resea…

1999

The purpose of this article is to examine how two different corpora of material are suited for researching the sexuality of youth on the basis of material gathered via a structured questionnaire (N = 1183 response rate 87%) and via eight focus group discussions (FGDs) and to investigate the knowledge and opinions of adolescents at the age of 15 years about HIV infection and HIV-infected persons. Both boys and girls showed a good level of knowledge about HIV infection and AIDS. While their level of knowledge was good their attitude was that the threat of an HIV infection was not a personal issue. Furthermore negative attitudes to those having HIV/AIDS became more pronounced the more socially…

MaleAdolescentPsychology AdolescentPopulationHuman immunodeficiency virus (HIV)HIV InfectionsHuman sexualitymedicine.disease_causeEducationAcquired immunodeficiency syndrome (AIDS)Surveys and QuestionnairesHumansMedicineeducationHealth EducationFinlandResponse rate (survey)education.field_of_studybusiness.industryResearchPublic Health Environmental and Occupational HealthFocus Groupsmedicine.diseaseFocus groupAttitudeRespondentEducational StatusFemalebusinessDeveloped countryClinical psychologyHealth Education Research
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Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018

2022

Abstract Background Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to meet targets set for ending the epidemic by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the United Nations Sustainable Development Goals (SDGs). Precise HIV burden information is critical for effective geographic and epidemiological targeting of prevention and treatment interventions. Age- and sex-specific HIV prevalence estimates are widely available at the national level, and region-wide local estimates were recently published for adults overall. We…

MaleAdultSettore MED/17 - Malattie InfettiveAdolescentSettore MED/42 - Igiene Generale e ApplicataHIV InfectionsSettore MED/01 - Statistica MedicaYoung AdultHIV Infections/prevention & controlPregnancySeroepidemiologic StudiesGeneral & Internal MedicinePrevalenceHumansGeostatisticsAfrica; Demographics; Geostatistics; HIV; HIV prevalence; Mapping; Spatial statistics11 Medical and Health SciencesAfrica South of the SaharaAcquired Immunodeficiency SyndromeSpatial statisticsAcquired Immunodeficiency Syndrome/epidemiologyHIVGeneral MedicineMiddle AgedSettore SECS-S/04 - DemografiaAfrica South of the Sahara/epidemiology3142 Public health care science environmental and occupational healthHIV prevalenceMapping3121 General medicine internal medicine and other clinical medicineAfricaDemographicsFemaleBMC Medicine
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Association between food insecurity and fall-related injury among adults aged ≥65 years in low- and middle-income countries: The role of mental healt…

2021

Purpose:\ud \ud We investigated the association between food insecurity and fall-related injury among older adults from six low- and middle-income countries (LMICs), and the extent to which this association is mediated by mental health.\ud \ud Methods:\ud \ud Cross-sectional, community-based, nationally representative data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. Past 12-month food insecurity was assessed with two questions on frequency of eating less and hunger due to lack of food. Fall-related injury referred to those that occurred in the past 12 months. Multivariable logistic regression analysis and mediation analysis were conducted to assess association…

MaleAgingHealth (social science)*Low- and middle-income countriesPsychological interventionLogistic regressionFood SupplyOdds03 medical and health sciencesOlder adults.0302 clinical medicineFall-related injuryEnvironmental health*Fall-related injuryPrevalenceHumansMedicine030212 general & internal medicineDeveloping CountriesDepression (differential diagnoses)Aged*Older adults2. Zero hungerLow- and middle-income countries030214 geriatricsFood insecuritybusiness.industry[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontologyConfoundingCognitionMESH: Accidental Falls Aged Cross-Sectional Studies Developing Countries Female Food Insecurity Food Supply Humans Male Mental Health PrevalenceMental health3. Good healthCross-Sectional StudiesMental HealthLow- and middle-income countrie*Food insecurityOlder adultsAnxietyAccidental FallsFemaleGeriatrics and Gerontologymedicine.symptombusinessGerontologyThe role of mental health conditions.- Archives of gerontology and geriatrics cilt.96 ss.104438 2021 [Smith L. Shin J. I. López-Sánchez G. F. Veronese N. Soysal P. Oh H. Grabovac I. Barnett Y. Jacob L. Koyanagi A. -Association between food insecurity and fall-related injury among adults aged ≥65 years in low- and middle-income countries]
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SARS CoV2 infection _The longevity study perspectives

2021

Graphical abstract

MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Monkeypox proctitis treated with doxycycline in an HIV MSM returning to Italy from France

2022

No abstract available

MaleAnal painProctitiPublic Health Environmental and Occupational HealthHIV InfectionsMonkeypoxLymphogranuloma venereumAnti-Bacterial AgentsInfectious DiseasesDoxycyclineMonkeypox viruAnti-Bacterial AgentLymphogranuloma Venereum.HumansProctitisHIV InfectionHomosexuality MaleHuman
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