Search results for "HIV"
showing 10 items of 1527 documents
Human immunodeficiency virus infection in cells of myeloid-monocytic lineage.
1991
We established persistent infection with a strain of human immunodeficiency virus type 1, HTLV-IIIB, in a promyelomonocytic cell line, ML-1 (CD4 antigen nearly negative and CD4 mRNA negative), and a promonocytic cell line, THP-1 (CD4 antigen positive). Different reaction of giant cell formation was found after co-cultivation of infected and uninfected cells of ML-1, HL-60, THP-1 and U-937 cell lines with uninfected and infected MOLT4 (a T-lymphoma cell line).
2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.
2004
Several 1,3-thiazolidin-4-ones bearing a 2,6-dihalophenyl group at C-2 and a substituted pyrimidin-2-yl ring at the N-3 were synthesised and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of human immunodeficiency virus type-1 (HIV-1) replication at 10–40 nM concentrations with minimal cytotoxicity. Structure–activity relationship studies revealed that the nature of the substituents at the 2 and 3 positions of the thiazolidinone nucleus had a significant impact on the in vitro anti-HIV activity of this class of potent antiretroviral agents. The compounds had significantly reduced activity against the characteristic N…
Graduate of Riga Polytechnic Institute, Engineer and Athlete Mārtiņš Stabiņš
2020
The aim of the article is to reveal the performance of Mārtiņš Stabiņš, a graduate of the Faculty of Automation and Computer Technology (1972; FACT) of Riga Polytechnic Institute (RPI), in the profession of engineer and high achievements in sports, becoming a Latvian champion in athletics several times, to reveal his daily life during his study years in the 1960s–1970s. Despite the fact that M. Stabiņš’ sports achievements have already described, this article summarizes his successes as well as reveals hitherto little-known and unpublished documents about his family, daily life, developments and interests. This is the first major research on the life of an engineer and athlete during seven …
Ruolo dell'interazione NK/KIR nella storia naturale delle infezioni virali
2017
Immunological mechanisms involved in the genesis of the immune response against viral infections take into account the activation of both innate adaptative response. Innate immune defenses trigger a rapid local response, which is often sufficient to control viral infection, and promotes the subsequent activation of specific immune defenses. Natural killer (NK) cells that constitute a subpopulation of lymphocyte-related cells are a key factor of innate immune response and play a role in defense against viral infections by killing infected cells or by producing cytokines and interacting with adaptative immune system's cells. Killer immunoglobulin-like receptors (KIRs) regulate the activation …
Typical Aspects of the Microwave Noise Performance of HEMTs at Decreasing Temperatures
1996
In analog signal processing at microwave frequencies the noise performance of active devices is of fundamental importance for the accurate design of low-noise amplifiers. To this aim, the determination of the four noise parameters F O , Γ O (complex variable) and Rn has to be accomplished together with the usual scattering parameter measurements vs. frequency. In addition, the dependence of the device performance vs. temperature is of interest for circuit applications characterized by harsh environmental conditions. In this work the noise behavior of high electron mobility transistors has been investigated by means of measurements and modeling in the 2-18 GHz frequency range and as a functi…
A Sliding Window-Based Method to Detect Selective Constraints in Protein-Coding Genes and Its Application to RNA Viruses
2002
Here we present a new sliding window-based method specially designed to detect selective constraints in specific regions of a multiple protein-coding sequence alignment. In contrast to previous window-based procedures, our method is based on a nonarbitrary statistical approach to find the appropriate codon-window size to test deviations of synonymous (d(S)) and nonsynonymous (d(N)) nucleotide substitutions from the expectation. The probabilities of d(N) and d(S) are obtained from simulated data and used to detect significant deviations of d(N) and d(S) in a specific window region of the real sequence alignment. The nonsynonymous-to-synonymous rate ratio (w = d(N)/d(S)) was used to highlight…
NATURAL SELECTION AND THE ORGAN-SPECIFIC DIFFERENTIATION OF HIV-1 V3 HYPERVARIABLE REGION
2004
The existence of organ-specific HIV-1 populations within infected hosts has been studied for many years; nonetheless results reported by different authors are somewhat discrepant. To tackle this problem, we used a population genetics approach to analyze previously published data from the V3 hypervariable region of the envelope env gene. Our results are compatible with a population subdivision by organs in 95% of individuals analyzed at autopsy. In addition, populations infecting the nervous system and testicles clearly appear as differentiated subsets of the so-called macrophage-tropic variants. Liver and kidney may harbor differentiated populations as well. Although it is widely accepted t…
Archivio Giuseppe Caronia (Palermo 1915 – Roma 1994)
2010
Nel quadro di un censimento degli archivi urbanistici in Italia si rende conto della consistenza e dei contenuti dell’ Archivio Giuseppe Caronia che fa parte delle Collezioni speciali, frutto di donazioni, che hanno sede presso il Dipartimento di Storia e progetto nell'Architettura dell'Università di Palermo
Fermi-Dirac correlations in Lambda pairs in hadronic Z decays
2000
Two-particle correlations of Lambda Lambda and pairs have been studied in multihadronic Z decays recorded with the ALEPH detector at LEP in the years from 1992 to 1995. The correlations were measured as a function of the four-momentum difference Q of the pair. A depletion of events is observed in the region Q 2 GeV the fraction of pairs with spin one is consistent with the value of 0.75 expected for a statistical spin mixture, whilst for Q pairs, where no Fermi-Dirac correlations are expected, the spin one fraction is measured to be consistent with 0.75 over the entire analysed Q range. (C) 2000 Elsevier Science B.V. All rights reserved.
Le fonds Schneider et compagnie dans la grande guerre
2018
National audience; Intervention dans le cadre d'un colloque organisé par l’Académie François Bourdon, la Maison des Sciences de l’Homme de Dijon, la mission histoire de la Société Générale et le réseau Archives numériques des mondes contemporains.