Search results for "HIV"

Evolution of patients’ socio-behavioral characteristics in the context of DAA: Results from the French ANRS CO13 HEPAVIH cohort of HIV-HCV co-infecte…

2018

International audience; BACKGROUND:Direct-acting antivirals (DAA) have dramatically increased HCV cure rates with minimal toxicity in HIV-HCV co-infected patients. This study aimed to compare the socio-behavioral characteristics of patients initiating pegylated-interferon (PEG-IFN)-based HCV treatment with those of patients initiating DAA-based treatment.METHODS:ANRS CO13 HEPAVIH is a national multicenter prospective cohort started in 2005, which enrolled 1,859 HIV-HCV co-infected patients followed up in French hospital outpatient units. Both clinical/biological and socio-behavioral data were collected during follow-up. We selected patients with socio-behavioral data available before HCV tr…

Home-based HIV testing: Using different strategies among transgender women in Argentina.

2019

Background In Argentina, HIV prevalence among transgender women (TGW) has been reported at 34%. The stigma is one of the most important factors limiting their access to healthcare services. The aims of this study were to compare different HIV testing methodologies, to determine the factors associated with HIV diagnosis and to determine the feasibility of a home-based HIV testing service for TGW. Methods A multidisciplinary team performed home-based HIV testing interventions in four cities of Argentina. Participants self-identified as TGW, older than 14 years and with a negative or unknown HIV status. Blood samples were screened by two rapid tests (RT), one based on antibodies (Determine™ HI…

Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage

2021

The accessory protein Nef of human and simian immunodeficiency viruses (HIV and SIV) is an important pathogenicity factor known to interact with cellular protein kinases and other signaling proteins. A canonical SH3 domain binding motif in Nef is required for most of these interactions. For example, HIV-1 Nef activates the tyrosine kinase Hck by tightly binding to its SH3 domain. An archetypal contact between a negatively charged SH3 residue and a highly conserved arginine in Nef (Arg77) plays a key role here. Combining structural analyses with functional assays, we here show that Nef proteins have also developed a distinct structural strategy—termed the "R-clamp”—that favors the formation …

Rev protein suppression of complex formation between nuclear proteins and rev-responsive element-containing RNA of human immunodeficiency virus-1

1995

The Rev protein from human immunodeficiency virus type 1 (HIV-1) is known to bind Rev responsive element (RRE) sequence of HIV-1 mRNA. This interaction is thought to enhance expression of viral structural proteins but the mechanism for this effect is uncertain. The aim of this study was to investigate (i) whether other cellular proteins also bind to the RRE sequence and (ii) whether binding of cellular proteins to RRE RNA is influenced by Rev protein. Our results revealed that a variety of RNA-protein complexes are formed when in vitro transcribed RRE-containing RNA is incubated with proteins present in HeLa nuclear extracts. The molecular masses of the most prominent bands in RNase protect…

BALDONE OBSERVATORY IN THE CIRCLES OF TIME

2019

1957 – The first laboratory building, known as the White House, was built near Baldone on the Riekstu hill, in the territory of the next Observatory. 01.01.1958 – The Astronomy Sector was separated from the Institute of Physics and commenced independent activi- ty as the Laboratory of Astrophysics at the Latvian Acade- my of Sciences (LAS). In 1967, with the decision of the Presidium of the Latvian SSR LAS the Laboratory of As- trophysics was transformed into the Radioastrophysic Ob- servatory at LAS. Under the leadership of the first director, Janis Ikaunieks, an instrumental observation base develops – a 1.2m Schmidt telescope was installed in 1966 for opti- cal observations. The project …

La diagnostica delle malattie infettive: Tra metafora del passato e itinerario nel futuro

1993

A global emergency is threatening mankind, awakening dead ghosts and causing alarm about our present and future: it is the apparently irreversible spread of infectious diseases.This critical and worrying situation should be acknowledged and carefully followed by the radiological profession since all of us – teachers, specialists, professionals – have to deal with imaging diagnostic modalities deriving information from a deceitful and camouflageing anatomo-functional substratum.The increasing spread of infectious diseases is due to a wide range of concomitant factors: HIV infection, drug addiction, migration fenomena and the related opportunistic infections combined with poor hygienic, physi…

En los inicios de la experimentación de la albañilería moderna: Las escaleras de yeso en la arquitectura valenciana de los siglos XIV al XVI

2017

Translation, Adaption, and Psychometric Testing of the Myanmar Version of the Medical Outcomes Study Social Support Survey for People Living With HIV…

2021

Introduction: Valid and reliable instruments are crucial for measuring perceived social support among people living with HIV (PLHIV). We aimed to investigate the psychometric properties of the English version of the 19-item Medical Outcomes Study Social Support Survey (MOS-SSS) adapted for PLHIV in Myanmar.Methods: Based on a standard cross-cultural procedure, we adapted the MOS-SSS and formed a Myanmar version of the scale (MOS-SSS-M), and then tested its validity and reliability. A sample of 250 eligible PLHIV was collected from a closed Facebook group that included more than 10,000 Myanmars, most of whom were PLHIV.Results: The MOS-SSS-M achieved a Cronbach’s α of 0.82–0.95. Confirmatory…

A QM/MM study of the reaction mechanism for the 3′-processing step catalyzed by HIV-1 integrase

2009

Integrase (IN) is one of the three human immunodeficiency virus type 1 enzymes (HIV-1) essential for effective viral replication. This viral enzyme is involved in the integration of HIV DNA into host chromosomal DNA. In this work we have carried out molecular dynamics simulations using a hybrid Quantum Mechanics/Molecular Mechanics (QM/MM) approach to study the reaction mechanism for the 3′-processing step of DNA integration using a model substrate. The results obtained by QM(AM1)/MM and QM(PM3)/MM simulations have been improved by single-point corrections using an ab initio method to describe the quantum subsystem. The results obtained within this computational model can be used to obtain …

Luigi di Sarro: una modesta proposta

2011

Recensione sull'Archivio di Sarro