Search results for "HL60"

showing 3 items of 23 documents

Effects of extra virgin olive oil phenols on HL60 cell lines sensitve and resistant to anthracycline

2007

Settore BIO/14 - Farmacologiaphenols extra virgin oliv oil HL60
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ChemInform Abstract: Synthesis and Induction of G0-G1 Phase Arrest with Apoptosis of 3,5-Dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,…

2009

The multistep synthesis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one 15 has been carried out. The compound showed antiproliferative and apoptotic effects against K562, K562-R (imatinib mesilate resistant), HL60 and multidrug resistant (MDR) HL60 cell lines. Compound 15 showed a pro-apoptotic activity against HL60 and K562 resistant cell lines markedly higher than etoposide and busulfan, respectively. Flow cytometry studies carried out on K562 cells allowed to establish that 15 induces G0-G1 phase arrest followed by apoptosis.

Trifluoromethylmedicine.diagnostic_testHL60General MedicineMolecular biologyFlow cytometryMultiple drug resistancechemistry.chemical_compoundchemistryApoptosishemic and lymphatic diseasesmedicineBusulfanEtoposidemedicine.drugK562 cellsChemInform
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Cytotoxic effects of a crude extract of extra virgin olive oil on human HL60 cell lines sensitive and resistant with MDR phenotype

2008

drug resistance HL60 Olive oil
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