Search results for "HLA"

Processing of RNAs of the Family Avsunviroidae in Chlamydomonas reinhardtii Chloroplasts

2007

ABSTRACT The family Avsunviroidae comprises four viroid species with the ability to form hammerhead ribozymes that mediate self-cleavage of the multimeric plus and minus strands resulting from replication in the chloroplast through a symmetric rolling-circle mechanism. Research on these RNAs is restricted by their host range, which is limited to the plants wherein they were initially identified and some closely related species. Here we report cleavage and ligation in transplastomic Chlamydomonas reinhardtii expressing plus- and minus-strand dimeric transcripts of representative members of the family Avsunviroidae . Despite the absence of viroid RNA-RNA transcription, the C. reinhardtii -bas…

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

2011

Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 x 10(-16) and P = 4.1 x 10(-8), respectively).

Novel atrazine-binding biomimetics inspired to the D1 protein from the photosystem II of Chlamydomonas reinhardtii.

2020

Biomimetic design represents an emerging field for improving knowledge of natural molecules, as well as to project novel artificial tools with specific functions for biosensing. Effective strategies have been exploited to design artificial bioreceptors, taking inspiration from complex supramolecular assemblies. Among them, size-minimization strategy sounds promising to provide bioreceptors with tuned sensitivity, stability, and selectivity, through the ad hoc manipulation of chemical species at the molecular scale. Herein, a novel biomimetic peptide enabling herbicide binding was designed bioinspired to the D1 protein of the Photosystem II of the green alga Chlamydomonas reinhardtii. The D1…

Näkemys oikeudenmukaisuudesta ja kihlakunnantuomarin viraltapano 1700-luvun puolivälin Vanhassa Suomessa

2021

Sven Johan Östring hoiti Vanhassa Suomessa sijainneen Savonlinnan tuomiokunnan kihlakunnantuomarin virkaa reilun vuosikymmen ajan keväästä 1747 kesään 1760. Kihlakunnantuomarin ja tuomiokunnan rahvaan välit kärjistyivät 1750-luvun lopulla talonpoikien valittaessa toistuvasti tuomari Östringin väärinkäytöksistä. Talonpoikien mukaan kihlakunnantuomari Östring oli heidän vihamiehensä. Artikkelissa kysytään, miten virkavirhevalitusprosessit etenivät ja mitkä syyt johtivat lopulta kihlakunnantuomarin viraltapanoon. Kihlakunnantuomari Östringin väärinkäytökset olivat luonteeltaan pääasiassa taloudellisia. Valituksissa korostui kuitenkin taloudellisia menetyksiä vahvemmin talonpoikien näkemys oike…

B cell alloantigens in Sicilian patients with Crohn's disease.

1983

In Other Words: The Ethics of the Translator in 17th-century al-Andalus. The Perspective of Aḥmad Ibn Qāsim al-Ḥaǧarī al-Andalusī

2015

This study focuses on a particular aspect of the Translation Studies orDirāsāt al-tarǧamah, i.e. the ethics of the translator.Starting from the analysis of concepts like “cultural otherness” or “linguistic hospitality”, theorized by Antoine Berman, Lawrence Venuti and Paul Ricoeur, and concerning the translator’s process of mediating between languages and between cultures, it will be taken into account the specific case of a muslim traveller and interpreter, Aḥmad ibn Qāsim al-Ḥaǧarī al-Andalusī (d. 1051/1641), author of theKitāb Nāṣir al-dīn ʿalà l-qawm al-kāfirīn, who was asked, by a Christian authority (the Archbishop of Granada), to translate some Arabic manuscripts.In such a context, t…

Polish highlander jokes and their targets

2017

The aim of the paper is to identify the characteristic features of jokes about Polish highlanders and analyse them to isolate the comic script of a highlander. This group of jokes is treated as a good illustration of Christie Davies’s ethnic jokes theory concerning canny versus stupid and centre versus periphery oppositions, as well as mind over matter. A particular type of reasoning and the use of regional dialect are distinctive features of the joke targets that make it possible to perceive these jokes as a culturally specific phenomenon. The head shepherd (called baca) is the key character of the cycle. He is a very down-to-earth person, who is proud of his practical wisdom and has a ver…

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.

1995

A mutated cyclin-dependent kinase 4 (CDK4) was identified as a tumor-specific antigen recognized by HLA-A2. 1-restricted autologous cytolytic T lymphocytes (CTLs) in a human melanoma. The mutated CDK4 allele was present in autologous cultured melanoma cells and metastasis tissue, but not in the patient's lymphocytes. The mutation, an arginine-to-cysteine exchange at residue 24, was part of the CDK4 peptide recognized by CTLs and prevented binding of the CDK4 inhibitor p16INK4a, but not of p21 or of p27KIP1. The same mutation was found in one additional melanoma among 28 melanomas analyzed. These results suggest that mutation of CDK4 can create a tumor-specific antigen and can disrupt the ce…

[Pharmacogenomics of antiretrovirals].

2008

HIV infection is a serious but treatable disease, yet current treatment is limited by development of resistance and high rates of adverse drug reactions. Antiretroviral therapy is especially suitable for pharmacogenomic investigation as both drug exposure and treatment response can be reliably measured. Increasing knowledge about genes implicated in pharmacokinetics, mode of action, efficacy, and toxicity of drugs has already provided relevant results for clinical practice, for example: The strong association of the abacavir hypersensitivity reaction with HLA-B*5701 permits testing patients for the allele, and if present avoiding the drug and therefore preventing the reaction. Persons with …

Mitochondrial DNA variation of Drosophila obscura (Diptera: Drosophilidae) across Europe

2022

Drosophila obscura is a common fruit fly that inhabits the temperate forests of Europe. While it is abundant in the north compared to other Drosophila, its density decreases southwards, where it is gradually replaced by other Drosophila species. This study describes variation in the mitochondrial Cyt b gene of D. obscura from several European populations. We observed a large number of haplotypes, together with the structuring of genetic variation. Genetic variation is higher in the west where O1 and related divergent haplotypes dominate. In the east, the O2 haplotype is most frequent, together with haplotypes that recently arose from it. In the central part of the species range, both O1 and…