Search results for "HLA"

Graft-Versus-Host Disease or Infection: Rapid Detection of HLA Mismatch-Reactive T Cells Ex Vivo Can Facilitate Diagnosis and Guide Therapy after All…

2007

Abstract Diagnosis of graft-versus-host disease (GVHD) is mainly based on clinical features and on tissue biopsies. However, clinicians and pathologists are well aware of cases, in which GVHD cannot be distinguished from infections arising from severe immunodeficiency after allogeneic stem-cell transplantation (SCT). This may pose a deep therapeutic dilemma of whether to modify immunosuppressive treatment or to use donor lymphocyte infusion (DLI) for promoting anti-microbial immunity. We observed a 68-year-old patient with myelodysplastic syndrome who developed acute GVHD grade II of skin and gut at d+16 after T-cell depleted reduced-intensity SCT (Fig. 1). GVHD was confirmed by histology a…

The character and origin of the manuscripts in the present edition

1995

In the following I try to provide the reader with all the details needed to insert the Godel essays appearing here in the broader context of the rest of his unpublished work, as well as everything about my personal work on them. I start with a short description of what can be found in the Godel Nachlass in Princeton, USA, by referring to the catalogue prepared by John Dawson. Then I attempt to justify the particular selection I made of the manuscripts which I finally decided to study, reconstruct and publish. Such an explanation seems to be advisable given the great amount of Godel’s material unpublished but still extant. Also, I describe some of the historical details relevant to understan…

Importance of HLA-DR+ and CD1a+ Epidermal Cells for Cytokine Production in Psoriasis

1995

Psoriasis is an inflammatory skin disease characterised by marked hyperproliferation of keratinocytes in association with vascular expansion, leukocyte infiltration and lymphocyte activation1. Cytokines are thought to play a pivotal role in the pathogenesis. It is speculated that a dysregulation of the cytokine network involving tumor-necrosis-factor-a (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) might be the basic mechanism of the psoriatic inflammatory response2. TNF-α is the prototype of a proinflammatory peptide exerting immunomodulatory effects. IL-6 is a multifunctional cytokine with a broad range of biological functions in both acute and chronic inflammatory reactions. IL-8…

Asymptomatic carotid lesion as marker of future cerebrovascular and cardiovascular events in the follow-up: correlation with markers of inflammation …

2002

Carotenoids

2009

Publisher Summary This chapter provides an overview of what is known about carotenoid metabolism in Chlamydomonas with reference to other green algae and vascular plants. The biosynthesis of carotenoids and the subdivisions of carotenogenesis are described. With respect to subcellular distribution, the carotenoids in vegetative cells localize to the chloroplast where they either serve as photosynthetic pigments bound to the protein complexes of the two photosystems, or as components of the eyespot apparatus is outlined with its functional significance. Carotenoids can serve as precursors of a number of other molecules with important physiological functions in Chlamydomonas.

Characterization of HLA-DR- and TCR-binding residues of an immunodominant and genetically permissive peptide of the 16-kDa protein of Mycobacterium t…

2004

The 16-kDa protein of Mycobacterium tuberculosis represents an important antigenic target during bacillary latency and, consequently, should be considered as candidate subunit vaccine component. In this study, we have used CD4 T cell clones that recognize the peptide p91-110, an immunodominant and genetically permissive epitope, in the context of five different HLA-DR molecules and truncated and substituted variants of this peptide, to identify the minimal binding sequence (HLA-DR-binding core) and the minimal stimulatory sequence (TCR-binding core), as well as the residues that contact HLA-DR molecules and the TCR. We have found a common 9-mer sequence, spanning amino acids 93-101, as the …

TYPO-CHRONOLOGIE DES CÉRAMIQUES DU GROUPE RHIN-SUISSE-France -ORIENTALE (R.S.F.O.) DANS LA RÉGION DIJONNAISE :

2009

The archaeological site of the Pré-du-Plancher is located to the east of Dijon (Burgundy, Côte-d’Or), at the footof a limestone hill in the Basmont valley. This site, dated from the late Bronze Age, is the first to include a stratigraphicalsequence for this period in Burgundy. The settlement comprises of three buildings and several dumps containing potteryfinds. The study of the pottery as well as the site’s stratigraphy clearly identifies three chronological periods dating from Late Bronze Age IIb to Late Bronze age IIIa (French chronology) or Hallstatt A2 / B1 (German/Swiss chronology). Culturally, the site belongs to the Rhin-Suisse-France-Orientale group, the first phase showing influen…

Effects of cold acclimation and dsRNA injections on Gs1l gene splicing in Drosophila montana

2017

Abstract Alternative splicing, in which one gene produce multiple transcripts, may influence how adaptive genes respond to specific environments. A newly produced transcriptome of Drosophila montana shows the Gs1-like (Gs1l) gene to express multiple splice variants and to be down regulated in cold acclimated flies with increased cold tolerance. Gs1l’s effect on cold tolerance was further tested by injecting cold acclimated and non-acclimated flies from two distantly located northern and southern fly populations with double stranded RNA (dsRNA) targeting Gs1l. While both populations had similar cold acclimation responses, dsRNA injections only effected the northern population. The nature of …

Les plaques-boucles mérovingiennes ornées d'une croix encadrée par deux griffons : à propos d'une découverte faite à Fleurey-sur-Ouche (Côte-d'Or)

2010

The presentation of this copper alloy belt buckle decorated with a cross flanked by two griffons from Fleurey-sur- Ouche (Côte-d'Or), gives us the opportunity to review our knowledge of this type of buckle, the corpus of which has been recently enriched by new examples. Even though the fifteen known pieces can be categorized in the group D defined by the characteristic finds of the Burgundian kingdom, the iconographical theme remains quite diverse. Also, discoveries have been made all over this vast area, underlining the existence of several workshops, not only in the Jura put also in the Lauragais area.

Combined dynamics of the 500–600 nm leaf absorption and chlorophyll fluorescence changes in vivo: Evidence for the multifunctional energy quenching r…

2021

Carotenoids (Cars) regulate the energy flow towards the reaction centres in a versatile way whereby the switch between energy harvesting and dissipation is strongly modulated by the operation of the xanthophyll cycles. However, the cascade of molecular mechanisms during the change from light harvesting to energy dissipation remains spectrally poorly understood. By characterizing the in vivo absorbance changes (Delta A) of leaves from four species in the 500-600 nm range through a Gaussian decomposition, while measuring passively simultaneous Chla fluorescence (F) changes, we present a direct observation of the quick antenna adjustments during a 3-min dark-to-high-light induction. Underlying…