Search results for "HLA"
showing 10 items of 664 documents
"Mukaansa tempaavaa musiikkia" : kyselytutkimus yleisön musiikkimausta Kuopion Viinijuhlat -tapahtumassa kesällä 2009
2009
Karaistumisen ja lisääntymisdiapaussin vaikutukset Drosophila montana -mahlakärpästen kylmänkestävyyteen
2011
Kylmyys on yksi tärkeimmistä lajien levinneisyyteen ja runsauteen vaikuttavista stressitekijöistä. Karaistuminen ja lisääntymisdiapaussi ovat esimerkkejä hyönteisten fysiologisesta ja biokemiallisesta sopeutumista mataliin lämpötiloihin. Karaistumisella tarkoitetaan lyhyen ajan sisällä tapahtuvaa kylmänkestävyyden kasvamista, ja sillä voi olla huomattava vaikutus kylmistä olosuhteista selviytymiseen. Lisääntymisdiapaussin laukaisee ympäristöstä tulevat ärsykkeet, kuten muutokset päivän pituudessa ja lämpötilassa. Se parantaa naaraiden mahdollisuuksia selvitä epäedullisista vuodenajoista ja siirtää jälkeläisten tuoton ajankohtaan jolloin munien ja jälkeläisten selviytyminen on parhaimmillaan…
Monelta kantilta : Ilkka Nummelalle omistettu juhlakirja
2010
Årets fester och livets högtider i Astrid Lindgrens barnböcker
2015
Tämän tutkielman tarkoitus on toimia jatkona vuonna 2011 tekemälleni kandidaatintutkielmalleni joulusta Astrid Lindgrenin lastenkirjoissa. Tässä tutkimuksessa olen laajentanut teeman koskemaan muitakin kalenterivuotemme juhlia. Yhtälailla kuin kandidaatintutkielmassani on pro gradu-tutkielmassani tarkoitus tarkastella juhlien ja juhlaperinteiden kuvausta Lindgrenin lastenkirjoissa. Samalla pyrkimyksenä oli nostaa esille sekä kirjojen välillä että kirjojen ja ruotsalaisten juhlaperinteiden välillä esiintyviä yhtäläisyyksiä ja eroavuuksia. Juhlien lisäksi tarkastelin syntymän, kuoleman ja avioliiton kuvausta lastenkirjoissa, sillä kyseiset teemat liittyvät monesti elämän käännekohtiin ja yhdi…
Făgăraș as Jerusalem? Interethnic and interreligious ethos in Transylvania
2017
The study presents Transylvania as a space of ethnic-religious tolerance, having as a case studythe image of the town Făgăraș, as depicted in Eginald Schlattner’s novels. This space appearsas one of a heavenly nuance, based on a long tradition of coexistence of the members ofdifferent ethnic groups and religions. However, the inter-war and post-war period means theemergence of new challenges posed by the confrontation with the harmful effects of the twoideologies: Nazism and Communism. In this way, the dramas of the socio-historical contextinterweave with elements forming young Eginald. They will remain a constant in the writer’slife, offering Făgăraș the role of a forming educational array…
RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?
2019
Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) involved in IL23 driven pathways of inflammation. AS is also strongly associated with polymorphisms in two transcription factors, RUNX3 and T-bet (encoded by TBX21), which are important in T-cell development and function. The influence of these genes on the pathogenesis of AS and their potential for identifying drug targets is discussed here.
Human γδ T-Cells: From Surface Receptors to the Therapy of High-Risk Leukemias
2018
γδ T lymphocytes are potent effector cells, capable of efficiently killing tumor and leukemia cells. Their activation is mediated by γδ T-cell receptor (TCR) and by activating receptors shared with NK cells (e.g., NKG2D and DNAM-1). γδ T-cell triggering occurs upon interaction with specific ligands, including phosphoantigens (for Vγ9Vδ2 TCR), MICA-B and UL16 binding protein (for NKG2D), and PVR and Nectin-2 (for DNAM-1). They also respond to cytokines undergoing proliferation and release of cytokines/chemokines. Although at the genomic level γδ T-cells have the potential of an extraordinary TCR diversification, in tissues they display a restricted repertoire. Recent studies have identified …
HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy
2019
CD4+ T cells differentiate into various T helper subsets characterized by distinct cytokine secreting profiles that confer them effector functions adapted to a variety of infectious or endogenous threats. Regulatory CD4+ T cells are another specialized subset that plays a fundamental role in the maintenance of immune tolerance to self-antigens. Manipulating effector or regulatory CD4+ T cells responses is a promising immunotherapy strategy for, respectively, chronical viral infections and cancer, or severe autoimmune diseases and transplantation. Adoptive cell therapy (ACT) is an emerging approach that necessitates defining robust and efficient methods for the in vitro expansion of antigen-…
Chlamydia trachomatis Infection and Anti-Hsp60 Immunity: The Two Sides of the Coin
2009
Chlamydia trachomatis (CT) infection is one of the most common causes of reproductive tract diseases and infertility. CT-Hsp60 is synthesized during infection and is released in the bloodstream. As a consequence, immune cells will produce anti-CT-Hsp60 antibodies. Hsp60, a ubiquitous and evolutionarily conserved chaperonin, is normally sequestered inside the cell, particularly into mitochondria. However, upon cell stress, as well as during carcinogenesis, the chaperonin becomes exposed on the cell surface (sf-Hsp60) and/or is secreted from cells into the extracellular space and circulation. Reports in the literature on circulating Hsp and anti-Hsp antibodies are in many cases short on detai…
Sanojen sähköiset suhteet
2014
Professorin juhlaluento 11. joulukuuta 2013 Jyväskylän yliopistossa nonPeerReviewed