Search results for "HLA"
showing 10 items of 664 documents
Musiikkimatkailijan muotokuva : Viitasaaren Musiikin aika -festivaali 1992 ja 2007
2013
Tutkimuksessa tarkastellaan kysymyksiä mitä on musiikkimatkailu ja minkälainen on musiikkimatkaili-ja, käyttäen aineistona kesällä 2007 Viitasaaren Musiikin aika -nusiikkifestivaalilla tehtyä kyselytutki-musta, joka pohjautui Timo Cantellin (1993) kesällä 1992 Musiikin aika -musiikkifestivaalilla tekemään kyselytutkimukseen. Vuoden 2007 ja 1992 tuloksia vertaillaan keskenään käyttäen viitekehyksenä ai-neistojen analysoinnissa Hughesin (2000) teoriaa matkailusta, johon sisältyy taidekokemus, the arts-related tourism ja matkailijasta, the arts-related tourist, jonka matkaan kuuluu taidekokemus. Hughesin teoria rajaa tutkittaviksi kohteiksi nimenomaan esittävän taiteen, the peforming arts, joh…
Uudenmaan lääni
1893
Hämeen lääni
1861
Seminaarin kahdeksan Augustaa : Isa Aspin tilapäisrunous ja nimipäivien vieton yleistyminen Suomessa
2019
Suomessa luterilainen nimipäivien viettämisen tapa, joka oli omaksuttu säätyläispiireihin Ruotsista, alkoi levitä kaikkialle maahan 1800-luvun viimeisinä vuosikymmeninä. Nimipäiviin liittyi monenlaisia juhlaperinteitä, joita noudatettiin esimerkiksi Jyväskylän seminaarin kaltaisessa oppilaitoksessa, mistä ne kulkeutuivat edelleen opiskelijoiden mukana eri puolille Suomea. Nuori seminaarilainen lsa Asp oli jo ennen opintojensa alkamista kirjoittanut paljon nimipäivä- ja muita merkkipäivärunoja. Onnittelurunous oli tärkeä osa hänen arjen kirjallista vuorovaikutustaan lähipiirinsä kanssa ja samalla keino tuoda julkisuuteen runojaan nuorena naisrunoilijana, jonka tekstejä ei ollut vielä juurika…
Could PD-1/PDL1 immune checkpoints be linked to HLA signature?
2019
The outstanding clinical expansion of monoclonal antibodies (mAbs) to programmed cell death receptor-1 (PD-1) (nivolumab and pembrolizumab) and PD-1 ligand-1 (PDL-1) (atezolizumab, avelumab and durvalumab) has received an increasing level of interest regarding immunotherapy and multidrug combinations, for the treatment of a number of common human malignancies. Some patients treated with these agents receive remarkable benefits in term of quality of life, progression-free (PFS) and overall survival (OS). However, a significant percentage of these patients experience immune-related adverse events (irAEs), while others present with an ultra-rapid disease progression, defined as hyperprogressio…
Non-HLA Antibodies in Hand Transplant Recipients Are Connected to Multiple Acute Rejection Episodes and Endothelial Activation
2022
The role of anti-HLA antibodies in transplant rejection is well-known but the injury associated with non-HLA antibodies is now widely discussed. The aim of our study was to investigate a role of non-HLA antibodies in hand allografts rejection. The study was performed on six patients after hand transplantation. The control group consisted of: 12 kidney transplant recipients and 12 healthy volunteers. The following non-HLA antibodies were tested: antibody against angiotensin II type 1 receptor (AT1R-Ab), antibody against endothelin-1 type-A-receptor (ETAR-Ab), antibody against protease-activated receptor 1 (PAR-1-Ab) and anti-VEGF-A antibody (VEGF-A-Ab). Chosen proinflammatory cytokines (Il-1…
Human Papillomavirus Type 16 E7 Peptide-Directed CD8+ T Cells from Patients with Cervical Cancer Are Cross-Reactive with the Coronavirus NS2 Protein
2003
ABSTRACTHuman papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are required for cellular transformation and represent candidate targets for HPV-specific and major histocompatibility complex class I-restricted CD8+-T-cell responses in patients with cervical cancer. Recent evidence suggests that cross-reactivity represents the inherent nature of the T-cell repertoire. We identified HLA-A2 binding HPV16 E7 variant peptides from human, bacterial, or viral origin which are able to drive CD8+-T-cell responses directed against wild-type HPV16 E7 amino acid 11 to 19/20 (E711-19/20) epitope YMLDLQPET(T) in vitro. CD8+T cells reacting to the HLA-A2-presented peptide from HPV16 E711-19(20)recogni…
Plasticity in Photoperiodism : Drosophila montana Females Have a Life-Long Ability to Switch From Reproduction to Diapause
2022
Photoperiodic reproductive diapause is an essential part of female life cycle in several insect species living on high latitudes, where overwintering in reproductive stage involves high risks for survival and progeny production. The sensitive period (SP), during which photoperiodic cues can trigger the switch from direct development to diapause, can last from a few hours or days after emergence to the entire life span of females. Moreover, in some species, sexually mature females can enter post-reproductive diapause as a response to decreasing day length and/or temperature. We studied the duration of SP for diapause induction and the females’ ability to enter post-reproductive diapause at s…
Pyhäpäivien vietto varhaismodernin ajan Savossa (vuoteen 1710)
2016
In this dissertation, I study the observance of holy days among the peasantry in the early modern province of Savo, located on the eastern periphery of the Swedish kingdom (today Eastern Finland). I examine the practices, norms and meanings related to the observance of holy days both within and outside the Church, and analyse the changes and continuities in the post-reformation period. As the main sources of the study, I use district court records and visitation records mainly from the period 1639–1712. I analyse the cases with a micro-historical perspective and an anthropological approach. The lived religion of the peasantry was constituted especially through practices that were connected …
Pyhäpäivien vietto varhaismodernin ajan Savossa (vuoteen 1710). Lectio praecursoria 29.4.2016.
2016
FM Miia Kuhan Suomen historian väitöskirja Pyhäpäivien vietto varhaismodernin ajan Savossa (vuoteen 1710) tarkastettiin 29.4.2016 Jyväskylän yliopistossa. Vastaväittäjänä toimi dosentti Raisa Maria Toivo Tampereen yliopistosta ja kustoksena professori Kustaa H. J. Vilkuna Jyväskylän yliopistosta.