Search results for "HM"

A Prognostic Enrichment Strategy for Selection of Patients With Acute Respiratory Distress Syndrome in Clinical Trials.

2019

Incomplete or ambiguous evidence for identifying high-risk patients with acute respiratory distress syndrome for enrollment into randomized controlled trials has come at the cost of an unreasonable number of negative trials. We examined a set of selected variables early in acute respiratory distress syndrome to determine accurate prognostic predictors for selecting high-risk patients for randomized controlled trials.A training and testing study using a secondary analysis of data from four prospective, multicenter, observational studies.A network of multidisciplinary ICUs.We studied 1,200 patients with moderate-to-severe acute respiratory distress syndrome managed with lung-protective ventil…

Screening for Fabry disease in male patients with arrhythmia requiring a pacemaker or an implantable cardioverter-defibrillator

2021

Familial Sotos syndrome caused by a novel missense mutation, C2175S, in NSD1 and associated with normal intelligence, insulin dependent diabetes, bro…

2009

We report a familial Sotos syndrome in two children, boy and girl, aged 17 and 8 years, and in their 44 year old mother, who displayed normal intelligence at adult age, but suffered from insulin dependent diabetes mellitus, bronchial asthma, and severe lipedema. The underlying missense mutation, C2175S, occurred in a conserved segment of the NSD1 gene. Our findings confirm that familial cases of SS are more likely to carry missense mutations. This case report may prove useful to avoid underestimation of the recurrence rate of SS, and to demonstrate that the developmental delay may normalize, enabling an independent life and having an own family.

Brain lateralization of metrical accenting in musicians.

2009

The perception of meter, or the alternation of strong and weak beats, was assessed in musically trained listeners through magnetoencephalography. Metrical accents were examined with no temporal disruption of the serial grouping of tones. Results showed an effect of metrical processing among identical standard tones in the left hemisphere, with larger responses on strong than on weak beats. Moreover, processing of occasional increases in intensity (phenomenal accents) varied as a function of metrical position in the left hemisphere, but not in the right. Our findings support the view of a relatively early, left-hemispheric effect of metrical processing in musicians.

Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus.

1993

1. We have investigated the role of cyclic nucleotide phosphodiesterase IV (PDE IV) in the relaxation of human bronchus and guinea-pig trachea in vitro and in guinea-pigs in vivo. 2. Functional studies showed that the selective PDE IV inhibitors, rolipram and denbufylline, relaxed human and guinea-pig preparations in vitro. 3. Two clinically used xanthine non-selective PDE inhibitors, theophylline and pentoxifylline, were also effective in these preparations, but were much less potent than the selective agents used. 4. The rank order of potency for the four PDE inhibitors in both species was similar. 5. Biochemical studies indicated that PDE IV was the major PDE isoform present in the human…

Intensity of physical activity and respiratory function in subjects with and without bronchial asthma.

2007

The aim of this study was to assess the intensity of physical activity of asthmatic adults in Finland and the associations between the intensity of physical activity and respiratory function in asthmatic and nonasthmatic persons. The study population (n=8000) was drawn from the population register to represent the Finnish population aged 30 years or over. Adequate information was available from 7193 subjects (89.9% of the sample). Physical activity at work, at leisure and during commuting was recorded with a standard questionnaire. The responses to the questionnaire were expressed as MET values. Asthma was defined on the basis of self-reports of chronic diseases previously diagnosed by a ph…

Diurnal Variation in Maximal and Submaximal Strength, Power and Neural Activation of Leg Extensors in Men: Multiple Sampling Across Two Consecutive D…

2007

This study aimed to compare day-to-day repeatability of diurnal variation in strength and power. Thirty-two men were measured at four time points (07 : 00 - 08 : 00, 12 : 00 - 13 : 00, 17 : 00 - 18 : 00, and 20 : 30 - 21 : 30 h) throughout two consecutive days (day 1 and day 2). Power during loaded squat jumps, torque and EMG during maximal (MVC) and submaximal (MVC40) voluntary isometric knee extension contractions were measured. The EMG/torque ratio during MVC and MVC40 was calculated to evaluate neuromuscular efficiency. A significant time-of-day effect with repeatable diurnal patterns was found in power. In MVC, a significant time-of-day effect was present on day 2, whereas day 1 showed…

Diurnal Rhythm of the Muscular Performance of Elbow Flexors During Isometric Contractions

1996

The influence of time of day on elbow flexion torque was studied. Thirteen physical education students, 7 males and 6 females, made maximal and submaximal isometric contractions at 90 degrees of elbow flexors using a dynamometer. The torque developed was measured on each contraction. The myoelectric activity of the biceps muscle was also measured at the same time by surface electromyography (EMG) and quantified from the root mean square (RMS) activity. Torque and surface EMGs were measured at 6:00, 9:00, 12:00, 15:00, 18:00, 21:00, and 24:00 h over the same day. Oral temperature before each test session was measured on each occasion after a 30-min rest period. We observed a diurnal rhythm i…

Effects of exercise training on airway closure in asthmatics

2012

We previously reported that responsiveness to methacholine (Mch) in the absence of deep inspiration (DI) decreased in healthy subjects after a short course of exercise training. We assessed whether a similar beneficial effect of exercise on airway responsiveness could occur in asthmatics. Nine patients (male/female: 3/6; mean age ± SD: 24 ± 2 yr) with mild untreated asthma [forced expiratory volume in 1 s (FEV1): 100 ± 7.4% pred; FEV1/vital capacity (VC): 90 ± 6.5%] underwent a series of single-dose Mch bronchoprovocations in the absence of DI in the course of a 10-wk training rowing program (6 h/wk of submaximal and maximal exercise), at baseline ( week 0), and at week 5 and 10. The singl…

Circadian rhythms in human muscular efficiency: continuous physical exercise versus continuous rest. A crossover study.

2000

This study deals with the influence of time of day on neuromuscular efficiency in competitive cyclists during continuous exercise versus continuous rest. Knee extension torque was measured in ultradistance cyclists over a 24h period (13:00 to 13:00 the next day) in the laboratory. The subjects were requested to maintain a constant speed (set at 70% of their maximal aerobic speed obtained during a preliminary test) on their own bicycles, which were equipped with cyclosimulators. Every 4h, torque developed and myoelectric activity were estimated during maximal isometric voluntary contractions of knee extensors using an isokinetic dynamometer. Mesenteric temperature was monitored by telemetry.…