Search results for "HM"

Masstodon : a tool for assigning peaks and modeling electron transfer reactions in top-down mass spectrometry

2019

Abstract: Top-down mass spectrometry methods are becoming continuously more popular in the effort to describe the proteome. They rely on the fragmentation of intact protein ions inside the mass spectrometer. Among the existing fragmentation methods, electron transfer dissociation is known for its precision and wide coverage of different cleavage sites. However, several side reactions can occur under electron transfer dissociation (ETD) conditions, including nondissociative electron transfer and proton transfer reaction. Evaluating their extent can provide more insight into reaction kinetics as well as instrument operation. Furthermore, preferential formation of certain reaction products can…

Identification Of P.Leu167Del Apoe Gene Mutation By Next Generation Sequencing In A Large Hypercholesterolemic Family

2019

Cholesterol in Alzheimer’s Disease and other Amyloidogenic Disorders

2010

The complex association of cholesterol metabolism and Alzheimer’s disease is presented in depth, including the possible benefits to be gained from cholesterol-lowering statin therapy. Then follows a survey of the role of neuronal membrane cholesterol in Aβ pore formation and Aβ fibrillogenesis, together with the link with membrane raft domains and gangliosides. The contribution of structural studies to Aβ fibrillogenesis, using TEM and AFM, is given some emphasis. The role of apolipoprotein E and its isoforms, in particular ApoE4, in cholesterol and Aβ binding is presented, in relation to genetic risk factors for Alzheimer’s disease. Increasing evidence suggests that cholesterol oxidation p…

Guillaume Apollinaire, hymyilevä varas : intertekstuaalisuuden muodot L'Enchanteur pourrissant -teoksessa

2001

Simple connections between generalized hypergeometric series and dilogarithms

1997

AbstractConnections between generalized hypergeometric series and dilogarithms are investigated. Some simple relations of an Appell's function and dilogarithms are found.

Generalized hypergeometric functions and the evaluation of scalar one-loop integrals in Feynman diagrams

2000

Present and future high-precision tests of the Standard Model and beyond for the fundamental constituents and interactions in Nature are demanding complex perturbative calculations involving multi-leg and multi-loop Feynman diagrams. Currently, large effort is devoted to the search for closed expressions of loop integrals, written whenever possible in terms of known - often hypergeometric-type - functions. In this work, the scalar three-point function is re-evaluated by means of generalized hypergeometric functions of two variables. Finally, use is made of the connection between such Appell functions and dilogarithms coming from a previous investigation, to recover well-known results.

Heuristics and meta-heuristics for 2-layer straight line crossing minimization

2003

AbstractThis paper presents extensive computational experiments to compare 12 heuristics and 2 meta-heuristics for the problem of minimizing straight-line crossings in a 2-layer graph. These experiments show that the performance of the heuristics (largely based on simple ordering rules) drastically deteriorates as the graphs become sparser. A tabu search metaheuristic yields the best results for relatively dense graphs, with a GRASP implementation as close second. Furthermore, the GRASP approach outperforms all other approaches when tackling low-density graphs.

Sampling methods for low-frequency electromagnetic imaging

2007

For the detection of hidden objects by low-frequency electromagnetic imaging the linear sampling method works remarkably well despite the fact that the rigorous mathematical justification is still incomplete. In this work, we give an explanation for this good performance by showing that in the low-frequency limit the measurement operator fulfils the assumptions for the fully justified variant of the linear sampling method, the so-called factorization method. We also show how the method has to be modified in the physically relevant case of electromagnetic imaging with divergence-free currents. We present numerical results to illustrate our findings, and to show that similar performance can b…

Normal forms of hyperbolic logarithmic transseries

2021

We find the normal forms of hyperbolic logarithmic transseries with respect to parabolic logarithmic normalizing changes of variables. We provide a necessary and sufficient condition on such transseries for the normal form to be linear. The normalizing transformations are obtained via fixed point theorems, and are given algorithmically, as limits of Picard sequences in appropriate topologies.

Elastic plastic analysis iterative solution

1998

The step-by-step analysis of finite element elastic plastic structures subjected to an assigned (quasi-static) loading history, is considered; it identifies with the well-known sequence of linear complementarity problems. An iterative technique devoted to solve the relevant linear complementarity problem is presented. It is based on the recursive solution of a suitable linear complementarity problem, deduced from the relevant one and easier than it. The procedure convergency is proved. Some noticing particular cases are examined. The physical meaning of the procedure is shown to be a plastic relaxation. The suitable numerical ranges for some check parameter values, to be utilized in the app…