Search results for "HOMA"
showing 10 items of 956 documents
Effects of B-Cell Lymphoma on the Immune System and Immune Recovery after Treatment: The Paradigm of Targeted Therapy
2022
B-cell lymphoma and lymphoproliferative diseases represent a heterogeneous and complex group of neoplasms that are accompanied by a broad range of immune regulatory disorder phenotypes. Clinical features of autoimmunity, hyperinflammation, immunodeficiency and infection can variously dominate, depending on the immune pathway most involved. Immunological imbalance can play a role in lymphomagenesis, also supporting the progression of the disease, while on the other hand, lymphoma acts on the immune system to weaken immunosurveillance and facilitate immunoevasion. Therefore, the modulation of immunity can have a profound effect on disease progression or resolution, which makes the immune syst…
The Neoplastic Side of the Abdominal Wall: A Comprehensive Pictorial Essay of Benign and Malignant Neoplasms
2023
Abdominal wall neoplasms are usually benign and, in the majority of these cases, no further work-up or treatment is indicated. The percentage of malignant abdominal neoplasms, however, is not negligible. Radiologists play a pivotal role in identifying imaging features that should favor malignancy, including larger lesion size, edema, neurovascular involvement, and peripheral or inhomogeneous dynamic enhancement, thus indicating to the clinician the need for further work-up. Histopathology is the reference standard for the characterization of abdominal wall neoplasms. In patients undergoing surgery, radiological assessment is needed to guide the surgeon by providing a comprehensive anatomic …
Extending the Limits of Nature. Political Animals, Artefacts, and Social Institutions
2020
This essay discusses how medieval authors from the thirteenth and fourteenth centuries dealt with a philosophical problem that social institutions pose for the Aristotelian dichotomy between natural and artificial entities. It is argued that marriage, political community, and language provided a particular challenge for the conception that things which are designed by human beings are artefacts. Medieval philosophers based their arguments for the naturalness of social institutions on the anthropological view that human beings are political animals by nature, but this strategy required rethinking the borderline between nature and art. The limits of nature were extended, as social institution…
Pikettyn jälkipuintia
2017
Jokainen lause on merkki : novellitulkinta Thomas Pynchonin teoksesta The Crying of Lot 49
2014
Tässä tutkielmassa tarkastellaan, kuinka Thomas Pynchonin teosta The Crying of Lot 49 voidaan lukea novellina ja kuinka se sopii yhteen erilaisten novellimääritelmien kanssa. Novelliteorioiden kenttä on rikkonainen ja koostuu useiden teoreetikoiden joskus keskenään ristiriitaisistakin novellimääritelmistä. Tutkielmassa eri novellimääritelmissä mainittuja genrepiirteitä kuten pituutta, yhtenäisyyttä ja lopetuksen merkitystä tarkastellaan lähiluvun keinoin suhteessa The Crying of Lot 49:een. Tutkielmassa Pynchonin teoksen katsotaan edustavan erityisesti anekdoottista novellia eli novellimuotoa, jolla on selkeä juoni ja ajankesto ja joka on selvemmin yhteydessä genren amerikkalaiseen 1800-luvu…
The figurative path to Thomas Hardy's Far from the madding crowd
2001
Kognitīvo funkciju saistība ar bioķīmiskajiem rādītājiem 9-10 gadus veciem bērniem
2019
Pētījuma mērķis ir izpētīt saistību starp leptīnu, HOMA-IR indeksu un informācijas apstrādes ātrumu, impulsu kavēšanu, selektīvo vizuālo uzmanību, verbālo atmiņu un motoro ātrumu. Pētījumā piedalījās 88 bērni (51 meitene; 37 zēni) vecumā no 9 līdz 10 gadiem (M = 9,51; SD = 0,37). Pētījumā tika izmantotas 4 metodes kognitīvo funkciju mērīšanai: datorizēts Strūpa krāsu reakcijas tests, datorizēts simbolu – šifrēšanas tests, pirksta uzsitiena tests un Reja audiāli verbālās iemācīšanās tests. Papildus tika izmantoti analīžu rezultāti: leptīna līmenis asins plazmā (n = 62) un HOMA-IR indekss (n = 88). Pētījuma rezultāti norāda uz negatīvu saistību starp leptīnu un apstrādes ātrumu, savukārt HOMA…
Konstruktivistinen naiskuva ja sen rakentuminen Thomas Hardyn romaanissa Tess of the d'Urbervilles
2006
NPM-ALK-reactive T-cell responses in children and adolescents with NPM-ALK positive anaplastic large cell lymphoma
2019
ABSTRACT The oncoantigen nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces cellular and humoral immune responses in patients with NPM-ALK-positive anaplastic large cell lymphoma (ALCL). We characterize the NPM-ALK-specific T-cell responses in a cohort of pediatric and adolescent ALCL-patients in remission without Human Leucocyte Antigen (HLA)-preselection. First, we assessed NPM-ALK-reactive T-cell responses and their HLA-class I restriction in patients by using dendritic cells (DCs) transfected with in vitro transcribed (IVT) NPM-ALK-RNA for CD8 (n = 20) or CD3 (n = 9) T-cell stimulation. NPM-ALK-specific T-cells were detected in twelve of 29 patients (nine of 20 with CD8-selected…
Immunosenescence and lymphomagenesis
2018
Abstract One of the most important determinants of aging-related changes is a complex biological process emerged recently and called “immunosenescence”. Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysregulation may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. At present, the relationship between immunosenescence and lymphoma in elderly patients is not defined in a satisfactory way. This review presents a brief overview of the interplay between aging, cancer and lymphoma, and the key topic of immunosenescence is addressed in the context of t…