Search results for "HOMER"

2017

Disruption of the human SHANK3 gene can cause several neuropsychiatric disease entities including Phelan-McDermid syndrome, autism spectrum disorder (ASD), and intellectual disability. Although, a wide array of neurobiological studies strongly supports a major role for SHANK3 in organizing the post-synaptic protein scaffold, the molecular processes at synapses of individuals harboring SHANK3 mutations are still far from being understood. In this study, we biochemically isolated the post-synaptic density (PSD) fraction from striatum and hippocampus of adult Shank3Δ11-/- mutant mice and performed ion-mobility enhanced data-independent label-free LC-MS/MS to obtain the corresponding PSD proteo…

Homer2 and alcohol: A mutual interaction

2017

The past two decades of data derived from addicted individuals and preclinical animal models of addiction implicate a role for the excitatory glutamatergic transmission within the mesolimbic structures in alcoholism. The cellular localization of the glutamatergic receptor subtypes, as well as their signaling efficiency and function, are highly dependent upon discrete functional constituents of the postsynaptic density, including the Homer family of scaffolding proteins. The consequences of repeated alcohol administration on the expression of the Homer family proteins demonstrate a crucial and active role, particularly for the expression of Homer2 isoform, in regulating alcohol-induced behav…

Spatio-temporal deixis and cognitive models in early Indo-European

2018

AbstractThis paper is a comparative study based on the linguistic evidence in Vedic Sanskrit and Homeric Greek, aimed at reconstructing the space-time cognitive models used in the Proto-Indo-European language in a diachronic perspective. While it has been widely recognized that ancient Indo-European languages construed earlier (and past) events as in front of later ones, as predicted in the Time-Reference-Point mapping, it is less clear how in the same languages the passage took place from this ‘archaic’ Time-RP model or non-deictic sequence, in which future events are behind or follow the past ones in a temporal sequence, to the more recent ‘post-archaic’ Ego-RP model that is found only fr…

No association of alcohol dependence with HOMER 1 and 2 genetic variants.

2010

Several lines of evidence indicate that alterations of the central cortico-accumbens glutamate pathway are involved in the development and maintenance of alcohol- and substance-use disorders. The HOMER protein family is encoded by 3 genes HOMER (1–3) which are components of the excitatory postsynaptic density complex and function to modulate synaptic activity by the regulation of glutamate signaling. HOMER 1 and 2 have been reported to contribute to chronic alcohol-induced long-term neurochemical changes in the endogenous reward system. Data from animal models suggest a potential role of the Homer protein family in the development of alcohol and substance use. The aim of this study is to as…

A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice

2010

BACKGROUND: Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically by the preferential vulnerability of the dopaminergic nigrostriatal projection neurons. METHODOLOGY/PRINCIPAL FINDINGS: Here, we used two mouse lines overexpressing human A53T-SNCA and studied striatal dysfunction in the absence of neurodegeneration to understand early disease mechanisms. To characterize the progression, we employed young adult as well as old mice. Analysis of striatal neurotransmitter content demonstrated that dopamine (DA…

A Novel 1,4-Dihydropyridine Derivative Improves Spatial Learning and Memory and Modifies Brain Protein Expression in Wild Type and Transgenic APPSweD…

2015

Ca2+ blockers, particularly those capable of crossing the blood-brain barrier (BBB), have been suggested as a possible treatment or disease modifying agents for neurodegenerative disorders, e.g., Alzheimer's disease. The present study investigated the effects of a novel 4-(N-dodecyl) pyridinium group-containing 1,4-dihydropyridine derivative (AP-12) on cognition and synaptic protein expression in the brain. Treatment of AP-12 was investigated in wild type C57BL/6J mice and transgenic Alzheimer's disease model mice (Tg APPSweDI) using behavioral tests and immunohistochemistry, as well as mass spectrometry to assess the blood-brain barrier (BBB) penetration. The data demonstrated the ability …

On the second book of Quintus of Smyrna (in light of a recent comment)

2018

This paper aims to examine some textual problems in the second book of Quintus of Smyrna's Posthomerica, taking the cue from the recent commentary of Alessia Ferreccio. In the first part some assumptions of Ferreccio's work are discussed, while in the second part other passages are taken into account.

Design of Photovoltaic System for Rural Electrification in Rwanda

2017

Master's thesis Renewable Energy ENE500 - University of Agder 2017 In this century of accelerated development in various domains, some African countries are still facing a challenge of lack of power due to its scarce in some places, where by the main source of power (generation of electricity) is hydro since thermal and fuel are still on a small scale. This problem results in less productivity and economic decline of some countries like Rwanda which is among African countries that are at a very high speed in development, the grid lines from distant places are stack and they are few compared to the need of electricity in all corners of the country, especially in rural areas whereby each hous…

Homeric Evidences of an Inherently Actional Opposition: ἔρχομαι vs ἦλθον

2020

The paper aims at analyzing the paradigmatic relationship between the verbs ἔρχομαι and ἦλθον in Homeric Greek. Both verbs convey the idea of going within a Homeric suppletive paradigm. Although suppletivism between ἔρχομαι, εἶμι, ἐλεύσομαι (future), ἦλθον (aorist), εἰλήλουθα (perfect) is generally accepted, there is still uncertainty on both etymology and semantic features involving inherent actionality, with particular reference to ἔρχομαι. Therefore, the actional status of ἔρχομαι and its relationship with ἦλθον need further investigation. A textual analysis of the Homeric occurrences of both ἔρχομαι and ἦλθον, focusing on the semantic-syntactic discourse context, has shed light on their…

La genesi dei poemi omerici

2019

Si tratta della prima analisi sistematica di Iliade e Odissea scritta in una lingua diversa dal tedesco e del primo tentativo di dare un quadro generale delle analisi precedenti. Si cerca di distinguere i vari epe confluiti nei due poemi e come i Bearbeiter finali li hanno messi insieme. Le teorie panoraliste e unitarie vengono rifiutate, mentre vengono accettati i presupposti fondamentali dell’analisi, quale si è praticata per lo più da studiosi germanofoni nel sec. XIX e nella prima metà del XX.