Search results for "HORMONES"

Plausible Role of Estrogens in Pathogenesis, Progression and Therapy of Lung Cancer

2021

Malignant neoplasms are among the most common diseases and are responsible for the majority of deaths in the developed world. In contrast to men, available data show a clear upward trend in the incidence of lung cancer in women, making it almost as prevalent as breast cancer. Women might be more susceptible to the carcinogenic effect of tobacco smoke than men. Furthermore, available data indicate a much more frequent mutation of the tumor suppressor gene-p53 in non-small cell lung cancer (NSCLC) female patients compared to males. Another important factor, however, might lie in the female sex hormones, whose mitogenic or carcinogenic effect is well known. Epidemiologic data show a correlatio…

Maternally‐transferred thyroid hormones and life‐history variation in birds

2022

1. In vertebrates, thyroid hormones (THs) play an important role in the regulation of growth, development, metabolism, photoperiodic responses and migration. Maternally transferred THs are important for normal early-phase embryonic development when embryos are not able to produce endogenous THs. Previous studies have shown that variation in maternal THs within the physiological range can influence offspring phenotype. 2. Given the essential functions of maternal THs in development and metabolism, THs may be a mediator of life-history variation across species. 3. We tested the hypothesis that differences in life histories are associated with differences in maternal TH transfer across species…

Obtaining and research of callus mass of Gentiana lutea L roots

2015

The results of introduction to the culture in vitro Gentiana lutea L. are provided. The influence of phytohormones on growth processes of plant cells is researched, the optimal conditions for cultivation of Gentiana lutea L. are defined and chosen. Biomass extract is obtained and is researched on the presence in it the biologically active substances and antimicrobial activity.

Motherhood‐induced gene expression in the mouse medial amygdala: Changes induced by pregnancy and lactation but not by pup stimuli

2021

During lactation, adult female mice display aggressive responses toward male intrud-ers, triggered by male- derived chemosensory signals. This aggressive behavior is not shown by pup- sensitized virgin females sharing pup care with dams. The genetic mechanisms underlying the switch from attraction to aggression are unknown. In this work, we investigate the differential gene expression in lactating females ex-pressing maternal aggression compared to pup- sensitized virgin females in the me-dial amygdala (Me), a key neural structure integrating chemosensory and hormonal information. The results showed 197 genes upregulated in dams, including genes encoding hormones such as prolactin, growth h…

Growth-associated variation in body size, hormonal status, physical performance characteristics and perceptual-motor skills in Finnish young soccer p…

2013

Acute hormonal and muscular responses and recovery : chronic adaptations to single session combined strength and endurance training with regard to or…

2012

Combining both strength (S) and endurance (E) exercise loadings into a single training session can be considered to be of interest e.g. for time management purposes. However, the first loading in a combined session tends to produce notable acute fatigue responses, which can lead to the second loading being performed in a compromised state. Research on fatigue and recovery from a combined session with different loading orders is currently scarce, with even less attention given to the acute responses. Thus, this study investigated the long-term adaptations in the acute responses of a combined strength and endurance loading and whether or not there is an order effect. A total of 29 male subjec…

Mucin 1 deficiency mediates corticosteroid insensitivity in asthma

2019

BACKGROUND: The loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor asthma control and deterioration of airflow. Recent data indicate that Mucin 1 (MUC1) membrane mucin can mediate corticosteroid efficacy in chronic rhinosinusitis, but the role of MUC1 in uncontrolled severe asthma is unknown. The objective was to analyze the previously unexplored role of MUC1 on corticosteroid efficacy in asthma. METHODS: Mucin 1 expression was evaluated by real-time PCR in human bronchial epithelial cells (HBEC) and blood neutrophils from uncontrolled severe asthma (n=27), controlled mild asthma (n=16), and healthy subjects (n=13). IL-8, MMP9, and GM-CSF …

A 10-Week Block of Combined High-Intensity Endurance and Strength Training Produced Similar Changes in Dynamic Strength, Body Composition, and Serum …

2020

Purpose: To examine the potential sex differences in adaptations to combined endurance and strength training in recreationally endurance trained (eumenorrheic) women (n = 9) and men (n = 10). Methods: Isometric (ISOMmax) and dynamic bilateral leg press (1RM), countermovement jump (CMJ), running performance (3,000 m time trial), lean mass and body fat % (LEAN and FAT% determined by dual X-ray absorptiometry) as well as serum testosterone and cortisol (TES and COR, respectively, measured using hormone-specific immunoassay kits) were examined before a control period and pre, mid, and post a supervised 10-week combined high-intensity interval endurance training (4 × 4 min intervals and 3 × 3 × …

Fluctuations in muscle strength, shooting accuracy and serum hormone concentrations in conscripts during a 3-week combat training period

2015

Conscripts and soldiers have to perform their duties in a multistressor environment. During prolonged periods of combat training, fluctuations in strength levels and hormone concentrations have been noted. However, there is limited information regarding the changes in shooting performance and whether changes in strength and hormonal concentrations are correlated with it. This study examined strength levels, shooting performance and hormonal fluctuations during a 3-week combat training period. Possible correlations between the variables were examined and investigated. This study lasted for 37 days and involved 49 Finnish male conscripts as subjects. The subjects acted as their own controls d…

Social closeness,salivary hormones and physical exercise

2015

Introduction: Saliva collection and analysis is quickly becoming a useful and non-invasive tool for the evaluation of sport biomarkers. The aim of this study is to create a multidisciplinary assessment model, which can help to provide psychological and physiological responses, related to sport performances, social closeness and performance anxiety management in team sports. Materials and methods: We enrolled in our research 26 female volleyball players aged 13 ± 1 years old of three different teams (T1: 12 players; T2: 9 players; T3: 5 players). Saliva collection was carried out before and after the match for every team. Then we analyzed cortisol and progesterone concentrations through Elis…