Search results for "HOX"
showing 10 items of 1357 documents
Passive sampling in monitoring of nonylphenol ethoxylates and nonylphenol in aquatic environments
2012
The present practices for determining the concentration levels of various pollutants are in many respects insufficient and for this reason, there is an urgent need especially to develop more cost-effective sampling methods. In this study, a novel passive sampling tool (the Chemcatcher®) for monitoring nonylphenol ethoxylates (NPEOs) and nonylphenol (NP) in aqueous media was tested. These environmentally harmful substances have been widely used in different household and industrial applications and they affect aquatic ecosystems, for example, by acting as endocrine disrupting compounds. The highest accumulation of NPEOs and NP in laboratory-scale tests was obtained when using an SDB-XC (stan…
CCDC 278947: Experimental Crystal Structure Determination
2006
Related Article: Z.Halime, S.Balieu, M.Lachkar, T.Roisnel, P.Richard, B.Boitrel|2006|Eur.J.Org.Chem.|2006|1207|doi:10.1002/ejoc.200500685
PCR survey ofXenoturbella bockiHox genes
2007
Xenoturbella bocki has recently been identified as one of the most basal deuterostomes, although an even more basal phylogenetic position cannot be ruled out. Here we report on a polymerase chain reaction survey of partial Hox homeobox sequences of X. bocki. Surprisingly, we did not find evidence for more than five Hox genes, one clear labial/PG1 ortholog, one posterior gene most similar to the PG9/10 genes of Ambulacraria, and three central group genes whose precise assignment to a specific paralog group remains open. We furthermore report on a re-evaluation of the available published evidence of Hox genes in other basal deuterostomes.
Fishless-stream mayflies express behavioural flexibility in response to predatory fish
1996
The fish avoidance behaviour of nymphs of the grazing mayfly Baetis rhodani (Ephemerop- tera) was examined. The nymphs originated from a fishless stream. To study their responses to the addition of predator cues, nymphs were exposed to (1) chemical cues from a caged fish, or (2) a freely moving diurnal fish (European minnow, Phoxinus phoxinus). The nymphs immediately increased their refuge use when exposed to a live fish, whereas chemical cues alone did not cause any avoidance responses. In a second experiment, the eVects of (1) fish chemicals and (2) a fish model plus fish chemicals on the diel refuge use patterns of Baetis nymphs were examined. In the presence of a fish model, more nymphs…
Terpenoid Constituents ofZanthoxylum acanthopodiumDC. Leaves
2008
Abstract The chemical composition of the essential oil of Zanthoxylum acanthopodium DC. leaves was analyzed by GC and GC/MS. Fifty-eight compounds accounting for 75.6% of the oil were identified. The major compounds were linalool (14.3%), 9,12-octadecadien-ol (8.4%), 1,8-cineole (7.7%), 2-undecanone (7.3%), farnesol (3.6%), 9,12,15-octadecatrien-1-ol (3.2%) and β-caryophyllene (3.0%).
The Histone Acetyl-Transferase MOZ Cooperates with the Histone Methyl-Transferase MLL to Regulate HOX Gene Expression in Human Hematopoietic Stem Cel…
2008
Abstract MOZ (MOnocytic leukaemia Zinc finger protein) (also called MYST3 or KAT6A) is a member of the MYST family of HATs which likely acetylate H4K16. The MLL (MixedLineageLeukemia) gene is a frequent target for recurrent chromosomal translocations found in AML and ALL. MLL (KMT2A) is a methyl-transferase targeting H3K4. It was shown that MOZ/CBP leukemia, as observed in MLL-rearranged leukemias, harbors abnormal levels of homeobox (HOX) genes expression. HOX transcription factors have a crucial function in hematopoiesis regulation. In addition, HOXA5, HOXA7, and HOXA9 are often considered to be pivotal HOX genes for MLL transformation, constituting downstream targets of MLL. In our study…
Cytotoxicity of fagaramide derivative and canthin-6-one from Zanthoxylum (Rutaceae) species against multidrug resistant leukemia cells
2019
In our continuous search for cytotoxic compounds from the genus Zanthoxylum, chromatographic separation of the MeOH/CH2Cl2 (1:1) extract of Z. chalybeum yielded one new alkamide; 4-(isoprenyloxy)-3-methoxy-3,4-deoxymethylenedioxyfagaramide (1) and a known one; fagaramide (2). Similarly, from the MeOH/CH2Cl2 (1:1) extract of the stem bark of Z. parachanthum four known compounds; canthin-6-one (3), dihydrochelerythrine (4), lupeol (5) and sesamin (6) were isolated. Characterization of the structures of these compounds was achieved using spectroscopic techniques (NMR and MS). Using resazurin reduction assay 1, 3 and 6 displayed moderate cytotoxicity with IC50 values below 50 μM against the dru…
Cytotoxic alkaloids from the root of Zanthoxylum paracanthum (mildbr) Kokwaro
2021
Chemical investigation of the root of Zanthoxylum paracanthum afforded 1 new alkamide derivative, (2E,4E)-6-oxo-N-isobutyldeca-2,4-dienamide (1) together with 10 known congeners including one pheno...
CCDC 154579: Experimental Crystal Structure Determination
2001
Related Article: P.Sobota, K.Przybylak, J.Utko, L.B.Jerzykiewicz, A.J.L.Pombeiro, M.F.C.Guedes da Silva, K.Szczegot|2001|Chem.-Eur.J.|7|951|doi:10.1002/1521-3765(20010302)7:5<951::AID-CHEM951>3.0.CO;2-F
CCDC 1417215: Experimental Crystal Structure Determination
2015
Related Article: Tania Romero-Morcillo, Maksym Seredyuk, Carmen Muñoz, Jose A. Real|2015|Angew.Chem.,Int.Ed.|54|14777|doi:10.1002/anie.201507620