Search results for "HOX"

The longevity assurance homologue of yeast lag1 (Lass) gene family (Review)

2009

The Lass gene family contains a group of highly conserved genes that are found in eukaryotic species. The founding member, lag1, was discovered in a screen for yeast longevity genes. Subsequently, lag1 homologs were discovered in other organisms including six mammalian paralogs. All Lass genes encode a highly conserved Lag1 domain and many also have an additional Hox domain. Lass proteins are ceramide synthases and therefore are critical for ceramide biosynthesis. Ceramide synthase is also a critical enzyme in the sphingolipid biosynthetic pathway. As ceramide and sphingolipids are key intermediates in diverse cellular processes such as cell growth, apoptosis, and stress response and may al…

Occurrence of antibiotics and risk of antibiotic resistance evolution in selected Kenyan wastewaters, surface waters and sediments

2019

Active pharmaceutical ingredients, especially antibiotics, are micropollutants whose continuous flow into hydrological cycles has the potential to mediate antibiotic resistance in the environment and cause toxicity to sensitive organisms. Here, we investigated the levels of selected antibiotics in four wastewater treatment plants and the receiving water bodies. The measured environmental concentrations were compared with the proposed compound-specific predicted no-effect concentration for resistance selection values. The concentration of doxycycline, amoxicillin, sulfamethoxazole, trimethoprim, ciprofloxacin and norfloxacin within the influents, effluents, surface waters and river sediments…

Porous zirconia and titania as packing materials for high-performance liquid chromatography

1990

Abstract Porous amorphous zirconia (ZrO 2 ) and titania (TiO 2 ) packings were synthesized as rigid microparticulate beads by means of a sol—gel process. Sufficient rigidity and desired mesoporosity of the ZrO 2 and TiO 2 particles were achieved only by a gel hardening process, followed by heat treatment. The mean pore diameter, p d , the specific surface area, a s , and the specific pore volume, ν p , were controlled by the heat treatment. Typical values were p d = 8 nm, a s = 80 m 2 /g and ν p = 0.23 ml/g. ZrO 2 - and TiO 2 -based revesed-phase packings were prepared by subjecting the native materials to a specific activation process and reaction with octadecyltrimethoxysilane. Native ZrO…

Volatile Constituents of the Seed Coat ofZanthoxylum rhetsa(Roxb.) DC.

2010

Abstract The chemical composition of the volatile oil of Zanthoxylum rhetsa seed coat was analyzed by GC and GC/MS. Thirty-four compounds, accounting for 87.4% of the oil were identifed. The major compounds were terpinen-4-ol (32.1%), α-terpineol (8.2%), sabinene (8.1%), β-phellandrene (7.4%) and 2-undecanone (7.1%).

Structural and spectroscopic characterisation of 2-(2'-hydroxybenzoyl)pyrrole and its O-methyl derivative

2004

Abstract Density functional theory calculations on the tautomeric and conformational equilibria of 2-(2′-hydroxybenzoyl)pyrrole (HBP) and 2-(2′-methoxybenzoyl)pyrrole (MBP) were performed. Moreover, the experimental IR and UV spectra of the same compounds were recorded and compared with the theoretical data. The presence of an intramolecular hydrogen bond in HBP can be related to the biological activities of some of its derivatives.

Fluorescence labelling of organic acidic compounds with 4-bromomethyl-7-methoxycoumarin (Br-Mmc)

1977

4-Bromomethyl-7-methoxycoumarin (Br-Mmc) is introduced as a fluorescence marker for aromatic and heterocyclic acids. To investigate the applicability of this method on substances of different chemical classes, screening experiments with 110 compounds were carried out using a microrefluxer. Most aromatic and heterocyclic monocarboxylic acids gave Mmc-esters which are fluorescent on thin-layer plates, like the Mmc-esters of fatty acids, which have been previously investigated. Strong acids, alcohols, amides and most amines did not react, whereas certain cyclic amines such as piperidine gave strongly fluorescent derivatives. Mmc-phenyl ethers shows only weak fluorescence. A new standard proced…

Automated simultaneous triple dissolution profiles of two drugs, sulphamethoxazole-trimethoprim and hydrochlorothiazide-captopril in solid oral dosag…

2003

This article deals with the simultaneous determination of three dissolution profiles with the aid of the new and emerging continuous-flow methodology known as multicommutation. This methodology is based on a flow network of a set of solenoid valves controlled by the computer and acting as independent multicommutators to allow the easy and automated control of flowing solutions. The obtained three dissolution profiles from one dosage form are the whole formulation profile or "global profile" recommended by pharmacopoeias, and, at same time, are recorded two "individual" profiles from two drugs present in the formulation. This is the second attempt to obtain simultaneously three dissolution p…

Author response: Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo

2015

Computational methodologies applied to Protein-Protein Interactions for molecular insights in Medicinal Chemistry

2021

In living systems, proteins usually team up into “molecular machinery” implementing several protein-to-protein physical contacts – or protein-protein interactions (PPIs) – to exert biological effects at both cellular and systems levels. Deregulations of protein-protein contacts have been associated with a huge number of diseases in a wide range of medical areas, such as oncology, cancer immunotherapy, infectious diseases, neurological disorders, heart failure, inflammation and oxidative stress. PPIs are very complex and usually characterised by specific shape, size and complementarity. The protein interfaces are generally large, broad and shallow, and frequently protein-protein contacts are…

A convenient synthetic route to useful monobranched polyethoxylated halogen terminated [3,3 -Co(1,2-C2B9H11)2]- synthons

2009

An atom efficient and environmentally friendly route has been developed to obtain a new range of reagents in metallacarborane chemistry having monobranched polyethoxylated cobaltabisdicarbollide synthons. peer-reviewed