Search results for "HPLC-SEC"

UV/VIS spectroscopy as a method to characterize well water quality. [UV/VIS-spektroskopi som metod att karakterisera brunnsvattenkvalité]

2016

The applicability of UV/VIS spectroscopy for the characterization of well water quality was studied by analyzing 219 private wells from sparsely populated areas of Finland. In addition to conventional water quality indicators, such as conductivity, nitrate and DOC, a series of UV/VIS spectroscopic parameters were determined: A-224, A-254, A-280, A-365, A-436, the area under 250–350 nm, the area under 250–500 nm, SUVA-254, Molar Absorbance-280, Specific Color, A2/A3 and A2/A4, in order to find the most proper surrogate for the organic matter amount and the best indicator of organic matter quality. Three parameters, A-254, A-280 and the area under 250–350 nm were found to be applicable as sur…

Biophysical investigation on therapeutic proteins (Chaperonins, Hsp60 and CCT/TRiC) involved in human diseases

Molecular chaperones are indispensable cellular components that assist folding and assembly of newly synthesized proteins, translocation of proteins across membranes, as well as refolding and degrading of misfolded and aggregated proteins. In the last few years, innovative therapeutic strategies targeting stability and functionality of chaperones have received great attention, particularly in the field of neurodegenerative diseases. Moreover, the growing number of diseases found linked to chaperone mutations, testifies to the importance of their role in the cellular protein-quality control mechanism. The investigation of the biophysical interactions between chaperones and specific proteins …