Search results for "HRD"

Regional debris flow susceptibility assessment using HRDEM: Example of the city area of Messina (Sicily, Italy)

2014

Shallow landslide and debris flows are among the most dangerous natural hazards triggered by extreme meteorological events. These phenomena have recently caused catastrophic scenarios in Italy (e.g. in Sarno-Quindici and Giampilieri) and, according to expected changes in the climate pattern, an increasing frequency of these phenomena is expected. The aim of this research is to assess the debris flow susceptibility in the Giampilieri area (Sicily) using a spatially-distributed debris flow runout model based on topographic information. The application of the model starts with the identification of the source areas from which debris flows are propagated on the basis of frictional laws and flow…

TCR Clonality and Genomic Instability Signatures as Prognostic Biomarkers in High Grade Serous Ovarian Cancer.

2021

Simple Summary High-grade serous ovarian carcinoma (HGSC) could be analyzed with a molecular stratification defined by different genomic instability signatures associated with specific mutational process and prognostic biomarkers. Immune infiltrate is known to be a robust biomarker in HGSC. We aimed to investigate immune parameters according to genomic instability signatures. We observed that homologous recombination deficiency positive, copy cumber variant signature 7 and TCR (T cells receptor) clonality are good prognostic biomarkers in HGSC. Combining TCR clonality and genomic instability signature or T cell infiltration improved the prognostic value compared to each variable taken alone…

Trimmausta ja kriisihoitoa. Pääkirjoitus, Aikuiskasvatus 4/2003

2003

Supporting Creativity and Learning at Work : Practices and Structures from Growth Companies

2021

The constant change embedded in contemporary working life requires employees and organisations alike to continuously learn and, simultaneously, adapt and be creative. The potential to attract, manage and engage creative people, as well as support learning, has become increasingly important in organisational contexts. It is essential to recognise what the underlying learning theories are and how they connect with the current understanding of creativity. It is also important to study different manifestations of creativity and learning and reactively and proactively discover ways of supporting and developing both aspects in contemporary organisations. In this chapter, we first present our appr…

Sexual selection on song and cuticular hydrocarbons in two distinct populations of Drosophila montana

2011

Sexual selection has the potential to contribute to population divergence and speciation. Most studies of sexual selection in Drosophila have concentrated on a single signaling modality, usually either courtship song or cuticular hydrocarbons (CHCs), which can act as contact pheromones. We have examined the relationship between both signal types and reproductive success using F1–3 offspring of wild- collected flies, raised in the lab. We used two populations of the Holarctic species Drosophila montana that represent different phylogeographic clades that have been separate for ca. 0.5 million years (MY), and differ to some extent in both traits. Here, we characterize the nature and identify …