Search results for "HSD"
showing 10 items of 11 documents
Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆
2020
Background & Aims: Genetic factors associated with nonalcoholic fatty liver disease (NAFLD) remain incompletely understood. To date, most genome-wide association studies (GWASs) have adopted radiologically assessed hepatic triglyceride content as the reference phenotype and so cannot address steatohepatitis or fibrosis. We describe a GWAS encompassing the full spectrum of histologically characterised NAFLD. Methods: The GWAS involved 1,483 European NAFLD cases and 17,781 genetically matched controls. A replication cohort of 559 NAFLD cases and 945 controls was genotyped to confirm signals showing genome-wide or close to genome-wide significance. Results: Case-control analysis identified…
Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives
2018
A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-b-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced 62% HSD1 inhibition at 5 mM and, furthermore, three of them produced 68% inhibition at 1 mM. A docking-based structure-activity relationship analysis was done to determine the molecular basis of the inhibition and the cross-reactivity of the analogues was tested against oestrogen receptor, aromatase, cytochrome P450 1A2, and monoamine oxidases. Most of the analogues are only modestly active with 17-b-hydroxysteroid dehydrogenase 2 – a requirement for lowe…
17βhydroxysteroid deydrogenase-3 deficiency (17β HSD): clinical and endocrine features and molecular biology in two prepubertal patients
2004
Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.
2022
Funder: European Commission
Predicting breakthrough of vanadium in fixed-bed absorbent columns with complex groundwater chemistries: A multi-component granular ferric hydroxide−…
2020
Granular ferric hydroxide (GFH) is often used for fixed bed adsorbent (FBA) columns in groundwater purification units around the world to remove arsenate contaminations. Groundwater can contain also other toxic (e.g., antimonite and vanadate) and non-toxic oxo-anions (phosphate and silicic acid) that are known to affect FBA lifetimes. Therefore, understanding the breakthrough of toxic compounds intended for removal by FBA is essential to their design, and is important to predict accurately breakthrough curves (BTCs) for FBAs in waterworks to plan future operating costs. Rapid small-scale column tests (RSCCT) and pilot-scale FBA were used to simulate vanadate BTCs for complex groundwater che…
Performance of advanced transmission and reception algorithms for high speed downlink packet access
2008
Nykyisten kolmannen sukupolven (3G) matkaviestinverkkojen suorituskykyä voidaan parantaa huomattavasti käyttämällä erilaisia kehittyneitä tekniikoita tukiasemissa ja matkaviestimissä. Suorituskyvyn lisääminen on tarpeen langattoman liikenteen jatkuvasti kasvaessa. – Ihmisten liikkuvuus on huipussaan ja esimerkiksi työn sidonnaisuus yhteen paikkaan on vähentynyt. Tarve olla jatkuvasti yhteydessä tietoverkkoon on samalla lisääntynyt. Yhä useammalla on esimerkiksi ns. liikkuva laajakaista, jolla nopea Internet-yhteys on riippumaton paikasta, Nihtilä toteaa. Nihtilä tutki väitöskirjassaan erilaisten lähetin- ja vastaanotinalgoritmien suorituskykyä 3G-teknologia WCDMA:n (Wideband Code Division M…
Advanced receivers and antenna diversity in WCDMA HSDPA
2007
Enhancing the performance of HSDPA communication with multipoint transmission techniques
2015
The evolution of mobile phones, tablets and other mobile communication devices has led to a significant increase in the amount of data delivered over mobile networks. In order to satisfy the climbing data rate demands of customers, existing mobile broadband networks are being expanded with new features that allow ubiquitous and consistent networking experience. This research presents three multipoint transmission techniques for Wideband Code Division Multiple Access (WCDMA) based High-Speed Downlink Packet Access (HSDPA) communication protocol. Multiflow, High-Speed Single-Frequency Network (HS-SFN) and Multipoint-to-Point Single-Frequency Network (M2P-SFN) enable transmission of user-dedicat…