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showing 10 items of 20594 documents

CCDC 844439: Experimental Crystal Structure Determination

2013

Related Article: A.Fernandez-Mato,M.D.Garcia,C.Peinador,J.M.Quintela,M.Sanchez-Andujar,B.Pato-Doldan,M.A.Senaris-Rodriguez,D.Tordera,H.J.Bolink|2013|Cryst.Growth Des.|13|460|doi:10.1021/cg301656x

7-(34-Dimethoxyphenyl)-2-ethoxy-4-phenyl-18-naphthyridine-3-carbonitrileSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Unexpected Behavior of Enaminones: Interesting New Routes to 1,6-Naphthyridines, 2-Oxopyrrolidines and Pyrano[4,3,2-de][1,6]naphthyridines

2012

Reaction of enaminones 1a–d with 2-aminoprop-1-ene-1,1,3-tricarbonitrile (2) in the presence of AcOH/NH4OAc afforded 7-amino-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carbonitrile derivatives 9a–d. On the other hand, 2-aminopyrano[4,3,2-de] [1,6]naphthyridine-3-carbonitriles 20a–c,e were the only obtained products from the reactions of 1a–d with 2 in the presence of AcOH/NaOAc, while 1d afforded [3,5-bis-(4-chloro-benzoyl)-phenyl]-(4-chloro-phenyl)-methanone 21 under the same condition. The reaction of 2 with diethyl acetylenedicarboxylate in the presence of AcOH/NH4OAc afforded (4-cyano-5-dicyanomethylene-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-acetic acid eth…

7-amino-5-oxo-56-dihydro-16-naphthyridine-8-carbonitrileMagnetic Resonance Spectroscopy2-aminoprop-1-ene-113-tricarbonitrileMolecular StructureChemistryOrganic ChemistryPharmaceutical ScienceEthyl esterMedicinal chemistryArticleAnalytical Chemistrylcsh:QD241-441Diethyl acetylenedicarboxylate3-amino-2-cyanopent-2-enedinitrilelcsh:Organic chemistryChemistry (miscellaneous)enaminonesNitrilesDrug DiscoveryTransition TemperatureMolecular Medicineenaminones; 3-amino-2-cyanopent-2-enedinitrile; 7-amino-5-oxo-56-dihydro-16-naphthyridine-8-carbonitrile; 2-aminoprop-1-ene-113-tricarbonitrileNaphthyridinesPhysical and Theoretical ChemistryMolecules
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New tricyclic systems as photosensitizers towards triple negative breast cancer cells.

2022

AbstractNineteen pyrrolo[1,2-h][1,7]naphthyridinones and pyrido[2,3-c]pyrrolo[1,2-a]azepinones were synthesized as new tricyclic systems in which the pyridine ring is annelated to the 6,7-dihydroindolizin-8(5H)-one and 5,6,7,8-tetrahydro-9H-pyrrole[1,2-a]azepine-9-one moieties to obtain potential photosensitizing agents. They were tested for their photoantiproliferative activity on a triple-negative breast cancer cell line, MDA-MB-231, in the dark and under UVA light (2.0 J/cm2). We demonstrated that their toxicity, only when exposed to light, was primarily due to the generation of reactive oxygen species while their photodegradation products were not responsible for their activity. The mos…

7]naphthyridinonePhotosensitizing AgentsPyrrolo[12-h][17]naphthyridinoneCell DeathMDA-MB-231Organic ChemistryPhototoxic activityTriple Negative Breast NeoplasmsApoptosisPyrido[23-c]pyrrolo[12-a]azepinoneTriple-negative breast cancerPyrrolo[1Drug DiscoveryMolecular MedicineHumans2-h][1Pyrido[23-c]pyrrolo[12-a]azepinoneMDA-MB-231; Photosensitizing agents; Phototoxic activity; Pyrido[23-c]pyrrolo[12-a]azepinone; Pyrrolo[12-h][17]naphthyridinone; Triple-negative breast cancerReactive Oxygen SpeciesArchives of pharmacal research
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CCDC 749971: Experimental Crystal Structure Determination

2010

Related Article: Y.Rousselin, N.Sok, F.Boschetti, R.Guilard, F.Denat|2010|Eur.J.Org.Chem.|2010|1688|doi:10.1002/ejoc.200901183

8b8c-Dimethyldecahydro-2a4a6a8a-tetraazacyclopenta[fg]acenaphthylene-1-carbonitrileSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Eväitä elämään : kolmas- ja neljäsluokkalaisten oppilaiden käsityksiä itsetuntoon yhteydessä olevista tekijöistä koulussa

2000

9-10-vuotiaat lapsetala-asteluokkayhteisötoveritopettajatitsetuntolapset
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Torah, Temple, Land

2021

Veröffentlicht auf Englisch. Dieser Band widmet sich den Erscheinungsformen, in denen das Judentum in der Antike Gestalt annahm. Bekanntlich war das antike Judentum eine Religion in ständigem Wandel, mit unterschiedlichen Perspektiven auf zentrale Kategorien wie Tora, Tempel und Heiliges Land. Was als »Judentum« oder »jüdisch« angesehen wurde, stand demnach nicht einfach fest, sondern musste stets neu verhandelt werden.

900 Geschichte Geografie und Hilfswissenschaftenddc:900
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Fluvial activity of the late-glacial to Holocene “Bergstraßenneckar” in the Upper Rhine Graben near Heidelberg, Germany – first results

2022

Abstract. The term “Bergstraßenneckar” (BSN) refers to an abandoned course of the river Neckar. It flowed in a northern direction east of the river Rhine in the eastern part of the northern Upper Rhine Graben in southwestern Germany. The former meandering course merged with the Rhine ca. 50 km further north of the site of the present-day confluence near Mannheim. The palaeo-channels are still traceable by their depressional topography, in satellite images and by the curved boundaries of adjacent settlements and land parcels. In the plan view, satellite and aerial images reveal a succession of meander bends, with older bends being cut off from younger channels. Based on stratigraphic investi…

910 Geography and travel930 Alte Geschichte550 Earth sciences940 Geschichte Europas943 General history of Europe Central Europe940 General history of Europe910 Geografie943 Geschichte Deutschlands930 History of ancient world550 Geowissenschaften
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Strontium and oxygen isotope analyses reveal Late Cretaceous shark teeth in iron age strata in the Southern Levant

2020

930 Alte Geschichte550 Earth sciences930 History of ancient world550 Geowissenschaften
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Estudio y diagnóstico de nuevas virosis emergentes en vid (Vitis vinifera L.)

2022

La vid (Vitis vinifera L.) es una de las especies vegetales más susceptibles de padecer infecciones virales. En Europa y España, solo cinco especies virales (GFLV, ArMV, GLRaV-1, GLRaV-3 y GFkV), de las treinta y una patógenas de la vid, se encuentran bajo restricción legislativa. Algunos de estos son virus emergentes no contemplados en la legislación, siendo GPGV, GAMaV, GRLDaV, GVE, GVF, GVT, GRBV y GVCV las principales especies de virus emergentes que pueden constituir una amenaza para los cultivos españoles. Por tanto, el objetivo general de la presente tesis es conocer la situación de las principales virosis emergentes de vid en España y desarrollar herramientas de diagnóstico que pued…

:CIENCIAS AGRARIAS::Ciencias veterinarias ::Virología [UNESCO]UNESCO::CIENCIAS DE LA VIDA::Biología vegetal (Botánica) ::Fitopatologíaemergentes:CIENCIAS DE LA VIDA [UNESCO]diagnósticoNGSUNESCO::CIENCIAS DE LA VIDAUNESCO::CIENCIAS AGRARIAS::Ciencias veterinarias ::VirologíadetecciónHTS:CIENCIAS DE LA VIDA::Biología vegetal (Botánica) ::Fitopatología [UNESCO]virosisepidemiología
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El fundamento liberal del derecho a la intimidad

2021

T: The right to privacy is configured as a ?retaining wall? against State interference into the private sphere of people?s life. Throughout this work we will try to expose the philosophical-liberal foundations that have led us to what is now conceived as the ?right to privacy?.

:CIENCIAS JURÍDICAS [UNESCO]2070-8157 22082 Revista Boliviana de Derecho 584568 2021 32 8055215 El fundamento liberal del derecho a la intimidad Heras VivesGallego MoralesLuis de lasRight to privacyUNESCO::CIENCIAS JURÍDICASDaniel José T: The right to privacy is configured as a ?retaining wall? against State interference into the private sphere of people?s life. Throughout this work we will try to expose the philosophical-liberal foundations that have led us to what is now conceived as the ?right to privacy?. Derecho a la intimidadprivate sphere 70 95The right to privacy is configured as a ?retaining wall? against State interference into the private sphere of people?s life. Throughout this work we will try to expose the philosophical-liberal foundations that have led us to what is now conceived as the ?right to privacy?. Derecho a la intimidad [Daniel José T]liberalismoliberalismesfera privada
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