Search results for "HTI"
showing 10 items of 828 documents
Optimal Reporting of Predictions
1989
Abstract Consider a problem in which you and a group of other experts must report your individual predictive distributions for an observable random variable X to some decision maker. Suppose that the report of each expert is assigned a prior weight by the decision maker and that these weights are then updated based on the observed value of X. In this situation you will try to maximize your updated, or posterior, weight by appropriately choosing the distribution that you report, rather than necessarily simply reporting your honest predictive distribution. We study optimal reporting strategies under various conditions regarding your knowledge and beliefs about X and the reports of the other e…
Point process diagnostics based on weighted second-order statistics and their asymptotic properties
2008
A new approach for point process diagnostics is presented. The method is based on extending second-order statistics for point processes by weighting each point by the inverse of the conditional intensity function at the point’s location. The result is generalized versions of the spectral density, R/S statistic, correlation integral and K-function, which can be used to test the fit of a complex point process model with an arbitrary conditional intensity function, rather than a stationary Poisson model. Asymptotic properties of these generalized second-order statistics are derived, using an approach based on martingale theory.
Tests for Differentiation in Gene Expression Using a Data-Driven Order or Weights for Hypotheses
2005
In the analysis of gene expression by microarrays there are usually few subjects, but high-dimensional data. By means of techniques, such as the theory of spherical tests or with suitable permutation tests, it is possible to sort the endpoints or to give weights to them according to specific criteria determined by the data while controlling the multiple type I error rate. The procedures developed so far are based on a sequential analysis of weighted p-values (corresponding to the endpoints), including the most extreme situation of weighting leading to a complete order of p-values. When the data for the endpoints have approximately equal variances, these procedures show good power properties…
Adaptive Modifications of Hypotheses After an Interim Analysis
2001
It is investigated how one can modify hypotheses in a trial after an interim analysis such that the type I error rate is controlled. If only a global statement is desired, a solution was given by Bauer (1989). For a general multiple testing problem, Kieser, Bauer and Lehmacher (1999) and Bauer and Kieser (1999) gave solutions, by means of which the initial set of hypotheses can be reduced after the interim analysis. The same techniques can be applied to obtain more flexible strategies, as changing weights of hypotheses, changing an a priori order, or even including new hypotheses. It is emphasized that the application of these methods requires very careful planning of a trial as well as a c…
Systematic handling of missing data in complex study designs : experiences from the Health 2000 and 2011 Surveys
2016
We present a systematic approach to the practical and comprehensive handling of missing data motivated by our experiences of analyzing longitudinal survey data. We consider the Health 2000 and 2011 Surveys (BRIF8901) where increased non-response and non-participation from 2000 to 2011 was a major issue. The model assumptions involved in the complex sampling design, repeated measurements design, non-participation mechanisms and associations are presented graphically using methodology previously defined as a causal model with design, i.e. a functional causal model extended with the study design. This tool forces the statistician to make the study design and the missing-data mechanism explicit…
Stirling-perustaisen mikro-CHP-laitteiston prosessilaskenta ja lämmönvaihtimen mitoitus
2006
Estudios estructurales y funcionales de dUTPasas, una amplia familia de enzimas metabólicas con funciones reguladoras
2023
El dUTP es el nucleótido no canónico mayoritario en la célula. Su errónea incorporación en el ADN dispara los sistemas de reparación, los cuales pueden causar la muerte celular por una actuación ininterrumpida. Con el objetivo de prevenir esta situación, y conocida la incapacidad de las ADN polimerasas de distinguir entre el dTTP y el dUTP, las células poseen las proteínas dUTPasas (Duts), capaces de degradar este nucleótido no canónico y, en consecuencia, aumentar la ratio dTTP/dUTP en el pool de nucleótidos celular. A parte de la hidrólisis del dUTP, las Duts poseen otras funciones moonlighting, entre las cuales destaca la capacidad de Duts de fagos de Staphylococcus aureus de interaccion…
Bertel Strömmer ja Tampereen kaupunginarkkitehdin toimi vuosina 1918-1939
1997
Suolahden kadunnimet
2000
Naiset suomalaisten listayhtiöiden hallituksissa
2012
Naisten määrä pörssiyhtiöiden hallituksissa on alhainen lähes kaikkialla maailmassa. Poikkeus on Norja, jossa lainsäädäntö määrää, että molempien sukupuolten edustus listattujen yritysten hallituksissa on oltava 40 %. Naisten määrän lisäämistä hallituksissa pidetään tärkeänä, sillä tutkimusten mukaan yhtiöt, joiden hallituksissa on naisia, saavuttavat parempia tuloksia. Perimmiltään kysymys on kuitenkin eettinen tasa-arvokysymys. Naisten määrän lisäämiseksi suomalaisten yritysten hallituksissa on kaksi vaihtoehtoa; kiintiö Norjan tapaan tai vapaaehtoinen, listayhtiöiden hallinnointikoodin mukainen naisjäsenten nimittäminen hallituksiin. Naisten määrä suomalaisissa hallituksissa on kuitenkin…