Search results for "HUMAN HEALTH"
showing 10 items of 1622 documents
The montrachet study
2016
National audience; Summary The Montrachet Study (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) is a population‐based derived from the 3C Study performed in Dijon. In 2009–2011, 1153 participants from the 3 Cities Study, aged 75 years or more, had an initial eye examination. Apart from the old age of this population, the main interest is that information on cardiovascular and neurologic diseases and a large comprehensive database (blood samples, genetic testing, cognitive tests, MRI) were available. Our first results showed us that despite the high prevalence of self‐reported eye diseases in this elderly population, visual impairment was low and increased with age. Thes…
L’impact psychologique de la douleur en soins palliatifs : entre majoration de l’angoisse de mort et renforcement du sentiment d’existence, un impact…
2018
Resume La prise en charge de la douleur en soins palliatifs est une priorite. En effet, la presence d’un ressenti algique engendre chez le patient des repercussions importantes tant au niveau physique que psychologique. Les retentissements de la douleur sur la sphere psychique s’averent multiples, allant de la majoration de l’angoisse de mort au gel de la capacite de penser. Toutefois, paradoxalement, bien que la douleur perturbe le patient dans ses fondations existentielles, elle peut parfois presenter des fonctions au sein de la dynamique psychique. Cet article vise a questionner les retentissements psychologiques de la douleur en soins palliatifs, a interroger les fonctions que cette der…
Évolution du concept d’alliance thérapeutique en psychanalyse, de Freud à Renik
2012
Resume L’alliance therapeutique se definit comme la collaboration mutuelle, un partenariat, entre le patient et le therapeute dans le but d’accomplir les objectifs fixes. Ce concept a pris naissance en psychanalyse ou il a donne lieu a d’intenses debats. Nous proposons une synthese de ces debats, depuis les premieres intuitions de Freud jusqu’a l’actuel courant d’intersubjectivite. Ceci permet de mettre a jour les arguments d’une question qui n’est finalement pas tranchee, mais qui trouve cependant une voie d’expression dans les recherches portant sur les therapies breves analytiques. En effet, la confrontation d’idee a essentiellement porte autour du fait de savoir si la notion d’alliance …
Incertitude et présentification en hypnose clinique
2018
Nous proposons d’analyser une situation clinique dans une perspective de psychothérapie intégrative. Nous nous inscrivons dans le cadre de différentes approches : humaniste, psychodynamique, cognitive et comportementale, hypnose et EMDR. Dans ce contexte, nous présentons le parcours d’une patiente dont les réactions ont nécessité des aménagements du cadre thérapeutique et un changement de référentiel théorique. Nous sommes passés avec Mme Barnes d’un travail centré sur les cognitions et les comportements à une approche sensorielle et expérientielle par hypnose. La thérapie a initialement ciblé une symptomatologie anxieuse pour finalement se développer sur un versant existentiel intégrant la…
BIOAEROSOL
2017
Cultural heritage constitutive materials can provide excellent substrates for microbial colonisation, highly influenced by thermo-hygrometric parameters. In cultural heritage-related environments, a detrimental microbial load may be present both on manufact surface and in the aerosol. Confined environments (museums, archives, deposits, caves, hypogea) have peculiar structures and dif- ferent thermo-hygrometric parameters, influencing the development of a wide range of microbial species, able to induce artefact biodeterioration and to release biological particles in the aerosol (spores, cellular debrides, toxins, allergens) potentially dangerous for the human health (visitors/users). In orde…
Mineral analysis of human diets by spectrometry methods
2016
Abstract Mineral element determination in human diets is very important for human health, due to the presence in foods of essential and toxic elements or their incorporation in the manipulation and cooking food process. Different instrumental techniques have been used to determine mineral elements in human diets, but atomic spectroscopy and mass spectrometry based ones are the most commonly employed. Sampling procedures for diet analysis are the main critically step for mineral element determination, being employed different standardised protocols. This review summarised critically the state-of-the-art of mineral analysis in human diets, considering sampling, sample preparation and determin…
Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer
2020
Hepatocellular carcinoma (HCC) represents 80% of the primary hepatic neoplasms. It is the sixth most frequent neoplasm, the fourth cause of cancer-related death, and 7% of registered malignancies. Sorafenib is the first line molecular targeted therapy for patients in advanced stage of HCC. The present study shows that Sorafenib exerts free radical scavenging properties associated with the downregulation of nuclear factor E2-related factor 2 (Nrf2)-regulated thioredoxin 1 (Trx1) expression in liver cancer cells. The experimental downregulation and/or overexpression strategies showed that Trx1 induced activation of nitric oxide synthase (NOS) type 3 (NOS3) and S-nitrosation (SNO) of CD95 rece…
Assessment of tumor-infiltrating TCRV γ 9V δ 2 γδ lymphocyte abundance by deconvolution of human cancers microarrays
2017
Most human blood γδ cells are cytolytic TCRVγ9Vδ2+lymphocytes with antitumor activity. They are currently investigated in several clinical trials of cancer immunotherapy but so far, their tumor infiltration has not been systematically explored across human cancers. Novel algorithms allowing the deconvolution of bulk tumor transcriptomes to find the relative proportions of infiltrating leucocytes, such as CIBERSORT, should be appropriate for this aim but in practice they fail to accurately recognize γδ T lymphocytes. Here, by implementing machine learning from microarray data, we first improved the computational identification of blood-derived TCRVγ9Vδ2+γδ lymphocytes and then appl…
High-throughput sequencing for 1-methyladenosine (m1A) mapping in RNA
2016
Abstract Detection and mapping of modified nucleotides in RNAs is a difficult and laborious task. Several physico-chemical approaches based on differential properties of modified nucleotides can be used, however, most of these methods do not allow high-throughput analysis. Here we describe in details a method for mapping of rather common 1-methyladenosine (m1A) residues using high-throughput next generation sequencing (NGS). Since m1A residues block primer extension during reverse transcription (RT), the accumulation of abortive products as well as the nucleotide misincorporation can be detected in the sequencing data. The described library preparation protocol allows to capture both types …
Liver Fat Content in People with Pituitary Diseases: Influence of Serum IGF1 Levels
2017
AbstractNon-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome, and type 2 diabetes. NAFLD is also seen in patients with endocrinopathies. However, the relationship between endocrine diseases and the development of NAFLD is not well known. In this study, we set out to determine whether liver fat content (LFC) was associated with IGF1 levels in people with pituitary diseases (PD). Eighty-nine patients with pituitary diseases and 74 healthy controls were included in this study. LFC was measured using MRI. Hepatic steatosis was defined as LFC>5.5%. Patients with PD were older, and had a higher BMI than healthy controls. LFC was significantly higher…