Search results for "HYPOXIA"

When the brain goes diving: glial oxidative metabolism may confer hypoxia tolerance to the seal brain.

2009

Deep diving mammals have developed strategies to cope with limited oxygen availability when submerged. These adaptations are associated with an increased neuronal hypoxia tolerance. Brain neurons of the hooded seal Cysto- phora cristata remain much longer active in hypoxic condi- tions than those of mice. To understand the cellular basis of neuronal hypoxia tolerance, we studied neuroglobin and cy- tochrome c in C. cristata brain. Neuroglobin, a respiratory protein typically found in vertebrate neurons, displays three unique amino acid substitutions in hooded seal. However, these substitutions unlikely contribute to a modulation of O2 affinity. Moreover, there is no significant difference i…

Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles

2019

AbstractInteraction between the transcription factors, hypoxia-inducible factor (HIF1α and HIF2α) and Sp1, mediates hypoxia-driven expression of FVII gene encoding coagulation factor VII (fVII) in ovarian clear cell carcinoma (CCC) cells. This mechanism is synergistically enhanced in response to serum starvation, a condition possibly associated with tumor hypoxia. This transcriptional response potentially results in venous thromboembolism, a common complication in cancer patients by producing procoagulant extracellular vesicles (EVs). However, which deficient serum factors are responsible for this characteristic transcriptional mechanism is unknown. Here, we report that cholesterol deficien…

Functional role of biofouling linked to aquaculture facilities in Mediterranean enclosed locations

2020

Biofouling is generally considered a serious threat for human coastal activities such as aquaculture, and the ecological role of fouling organisms associated with fish-farm cages remains one of the most debated topics in the ecological field. However, although biofouling may cause significant problems related to human health, environmental impact and financial losses, in the past decade there has been an increasing interest in developing methods to promote the growth of biofouling on artificial structures as a strategy to mitigate human impacts and reduce the organic enrichment caused by net-cage fish farming. Here we investigated the filtration activity of biofouling assemblages colonizing…

Filtration pressure by bivalves affects the trophic conditions in Mediterranean shallow ecosystems

2009

Bivalve filtration may control the amount of seston in coastal waters, reducing local euthrophication and keeping degrading phenomena like hypoxia and anthropogenic pollution under control. Two Sicilian brackish-marine ponds (Ganzirri and Faro) present us with the opportunity to gain data on the effect of bivalve filtration on the amount of particulate organic matter in the field. The cultivation of bivalves has been carried out in both of the ponds since the early 1990s but stopped in Ganzirri in 1995.We tested whether the cessation of bivalve cultivation influenced features of organic matter available to suspension feeders (total suspended matter, its inorganic and organic fractions, chlo…

MULTIPLE CLIMATE-DRIVEN CASCADING ECOSYSTEM EFFECTS AFTER THE LOSS OF A FOUNDATION SPECIES

2021

Abstract Climate change is evolving so fast that the related adverse effects on the environment are becoming noticeable. Thus, there is an urgent need to explore and understand the effects generated by multiple extreme climatic events (MECEs) on marine ecosystem functioning and the services provided. Accordingly, we combined long-term in-situ empirical observations in the Mediterranean Sea with a mesocosm manipulation to investigate the concurrence of increasing temperature and hypoxia events. By focussing on a foundation mussel species, we were able to detect several cascade events triggered by a mass mortality event caused by stressful temperature and oxygen conditions, and resulting in a…

Effects of acute CPAP application on baroreflex control of heart rate during sleep in severe obstructive sleep apnea.

2006

Baroreflex control of heart rate during sleep (baroreflex sensitivity; BRS) has been shown to be depressed in obstructive sleep apnoea (OSA), and improved after treatment with continuous positive airway pressure (CPAP). Whether CPAP also acutely affects BRS during sleep in uncomplicated severe OSA is still debatable. Blood pressure was monitored during nocturnal polysomnography in 18 patients at baseline and during first-time CPAP application. Spontaneous BRS was analysed by the sequence method, and estimated as the mean sequence slope. CPAP did not acutely affect mean blood pressure or heart rate but decreased cardiovascular variability during sleep. Mean BRS increased slightly during CPAP…

Adipose tissue in sleep apnea: effects of hypoxia and inflammation

2014

Association between sensorineural hearing loss and sleep-disordered breathing: Literature review

2015

The cochlea is especially sensitive to circulatory alterations because it is supplied by a single terminal artery and lacks adequate collateral blood supply. To examine the putative association between Sensorineural Hearing Loss (SNHL) and Sleep Disordered Breathing (SDB) through the literature review is very interesting. In fact these medical disorders usually are associated to cerebral circulatory alterations resulting in hypoxia, acute hemodynamic change, and decreased cerebral blood flow, because the Sleep Disorder Breathing (SDB), for example OSAHS (Obstructive Sleep Apnea Hypopnea Syndrome), is characterized by periodic hyposia/reoxygenation. These noxious stimuli can, in turn, activa…

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax

2014

The blind mole rat (BMR), Spalax galili, is an excellent model for studying mammalian adaptation to life underground and medical applications. The BMR spends its entire life underground, protecting itself from predators and climatic fluctuations while challenging it with multiple stressors such as darkness, hypoxia, hypercapnia, energetics and high pathonecity. Here we sequence and analyse the BMR genome and transcriptome, highlighting the possible genomic adaptive responses to the underground stressors. Our results show high rates of RNA/DNA editing, reduced chromosome rearrangements, an over-representation of short interspersed elements (SINEs) probably linked to hypoxia tolerance, degene…

Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax.

2010

The subterranean mole rat Spalax is an excellent model for studying adaptation of a mammal toward chronic environmental hypoxia. Neuroglobin (Ngb) and cytoglobin (Cygb) are O 2 -binding respiratory proteins and thus candidates for being involved in molecular hypoxia adaptations of Spalax . Ngb is expressed primarily in vertebrate nerves, whereas Cygb is found in extracellular matrix-producing cells and in some neurons. The physiological functions of both proteins are not fully understood but discussed with regard to O 2 supply, the detoxification of reactive oxygen or nitrogen species, and apoptosis protection. Spalax Ngb and Cygb coding sequences are strongly conserved. However, mRNA and …