Search results for "Halogenated Diphenyl Ether"

showing 10 items of 32 documents

Can PBDEs affect the pathophysiologic complex of epithelium in lung diseases?

2020

Brominated flame-retardant (BFRs) exposure promotes multiple adverse health outcomes involved in oxidative stress, inflammation, and tissues damage. We investigated BFR effects, known as polybrominated diphenyl ethers (PBDEs) (47, 99 and 209) in an air-liquid-interface (ALI) airway tissue derived from A549 cell line, and compared with ALI culture of primary human bronchial epithelial cells (pHBEC). The cells, exposed to PBDEs (47, 99 and 209) (0.01-1 mu M) for 24 h, were studied for IL-8, Muc5AC and Muc5B (mRNAs and proteins) production, as well as NOX-4 (mRNA) expression. Furthermore, we evaluated tight junction (TJ) integrity by Trans-Epithelial Electrical Resistance (TEER) measurements, …

Lung DiseasesHealth Toxicology and Mutagenesis0208 environmental biotechnology02 engineering and technology010501 environmental sciencesMucin 5ACBROMINATED FLAME RETARDANTSmedicine.disease_cause01 natural sciencesPolybrominated diphenyl ethersPARTICULATE MATTERElectric ImpedanceHalogenated Diphenyl EthersFlame RetardantsInhalationTight junctionAIRWAY MUCUSChemistryGeneral Medicinerespiratory systemPollutionMucin-5BINTRACELLULAR GLUTATHIONEPolybrominated diphenyl ethers; Inflammation; Oxidative stress; Mucins; Epithelial barrier integrity; Rheological propertiesmedicine.anatomical_structureNADPH Oxidase 4medicine.symptomEnvironmental EngineeringInflammationBronchiEXPOSURE SYSTEMTight JunctionsAndrologymedicineEnvironmental ChemistryHumansRheological propertiesPolybrominated diphenyl ether0105 earth and related environmental sciencesAgedInflammationEpithelial barrier integrityPOLYBROMINATED DIPHENYL ETHERSMucinInterleukin-8MucinsPublic Health Environmental and Occupational HealthEpithelial CellsGeneral ChemistryN-ACETYLCYSTEINEEpithelium020801 environmental engineeringrespiratory tract diseasesOxidative StressA549 CellsMucinEX-VIVO MODELOxidative streRespiratory epitheliumAEROSOL-PARTICLESOxidative stressChemosphere
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Individual variation of persistent organic pollutants in relation to stable isotope ratios, sex, reproductive phase and oxidative status in Scopoli's…

2017

Abstract: Little is known about the accumulation of persistent organic pollutants (POPs) and its consequences for seabirds in the Mediterranean basin. We characterised the plasma contaminant profile (polychlorinated biphenyls ΣPCBs; organochlorine pesticides ΣOCPs; polybrominated diphenyl ethers ΣPBDEs) of a population of the seabird Scopoli's shearwater (Calonectris diomedea) that breeds in the southern Mediterranean (Linosa Island) and investigated (i) whether sex, stable isotope ratios (related to diet), reproductive phase (early incubation vs. late breeding season) and body mass explained variation in contaminant burden and (ii) whether they predict health-related variables. The predomi…

Male0106 biological sciencesEnvironmental EngineeringCalonectris diomedeaPopulationZoology010501 environmental sciences010603 evolutionary biology01 natural sciencesShearwaterMediterranean BasinBirdsPolybrominated diphenyl ethersbiology.animalHalogenated Diphenyl EthersHydrocarbons ChlorinatedMediterranean SeaSeasonal breederAnimalsEnvironmental ChemistryeducationBiologyWaste Management and Disposal0105 earth and related environmental sciencesEgg incubationeducation.field_of_studybiologyEcologyReproductionbiology.organism_classificationPolychlorinated BiphenylsAntioxidants Contaminants Isotopes Oxidative stress POPs SeabirdsPollutionOxidative StressChemistrySettore AGR/11 - Entomologia Generale E ApplicataEnvironmental PollutantsFemaleSeabirdEnvironmental Monitoring
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Method development for the simultaneous determination of polybrominated, polychlorinated, mixed polybrominated/chlorinated dibenzo-p-dioxins and dibe…

2013

An analytical methodology was developed for simultaneous determination of five groups of persistent organic pollutants (POPs) including polybrominated, polychlorinated and mixed brominated-chlorinated dibenzo-p-dioxins and dibenzofurans (PBDD/DFs, PCDD/DFs and PXDD/DFs, respectively), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in fish samples. The presented analytical approach was based on well established and robust method for determination of PCDD/DFs and PCBs, which was augmented with gas chromatography coupled to high resolution mass spectrometry (GC-HRMS) to include PBDEs, as well as poorly investigated PBDD/DFs and PXDD/DFs at toxicologically significa…

MaleEnvironmental EngineeringHealth Toxicology and MutagenesisSalmo salarFractionationDioxinsGas Chromatography-Mass SpectrometryPolybrominated diphenyl ethersHalogenated Diphenyl EthersEnvironmental ChemistryAnimalsHrgc hrmsBenzofuransPollutantChemistryPublic Health Environmental and Occupational HealthGeneral MedicineGeneral ChemistryPollutionMethod developmentLatviaPolychlorinated BiphenylsEnvironmental chemistryChlorinated Dibenzo-p-dioxinsChromatography GelFish <Actinopterygii>FemaleGas chromatographyWater Pollutants ChemicalEnvironmental MonitoringChemosphere
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PBDEs affect inflammatory and oncosuppressive mechanisms via the EZH2 methyltransferase in airway epithelial cells

2021

Abstract Aims We aimed to investigate the effect of PBDEs (47, 99, 209) on cellular events involved in epigenetic modification, inflammation, and epithelial mesenchymal transition (EMT). Materials and methods We studied: 1) ERK1/2 phosphorylation; 2) Enhancer of Zester Homolog 2 (EZH2); 3) Histone H3 tri-methylated in lysine 27 (H3K27me3); 4) K-RAS; 5) silencing disabled homolog 2-interacting protein gene (DAB2IP), 6) let-7a; 7) Muc5AC/Muc5B, and 8) IL-8 in a 3D in vitro model of epithelium obtained with primary Normal Human Bronchial Epithelial cells (pNHBEs) or A549 cell line, chronically exposed to PBDEs (47, 99, 209). Key findings PBDEs (10 nM, 100 nM and 1 μM) increased ERK1/2 phosphor…

MaleLung NeoplasmsMethyltransferaseRespiratory Mucosamacromolecular substancesAirway epithelial cellsGeneral Biochemistry Genetics and Molecular BiologyHistone H3Airway epithelial cellHalogenated Diphenyl EthersPolybrominated diphenyl ethersHumansGene silencingEnhancer of Zeste Homolog 2 ProteinEpigeneticsEpithelial–mesenchymal transitionGeneral Pharmacology Toxicology and PharmaceuticsProtein gene (DAB2IP)AgedFlame RetardantsInflammationA549 cellChemistryEZH2Epithelial CellsLet-7aGeneral MedicineMiddle AgedNeoplasm ProteinsA549 CellsCancer researchDisabled homolog 2 interactingPhosphorylationFemaleLung cancerLife Sciences
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Assessing persistent organic pollutants (POPS) in the sicily island atmosphere, mediterranean, using PUF disk passive air samplers

2016

In this study, PUF disk passive air samplers were deployed at eight sites, during two sampling periods, on the Island of Sicily in the Mediterranean basin. Samples were screened for a number of persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs) (n = 28 congeners), organochlorine pesticides (OCPs) (n = 16 compounds), and polybrominated biphenyl ethers (PBDEs n = 28) using GC-MS. PCB concentrations in air ranged ~10-300 pg m-3. The PCB pattern was dominated by lower to middle molecular weight PCBs (Cl3-5) and PCB-28 and PCB-52 were the most abundant congeners. α- and γ-Hexachlorocyclohexanes (HCHs) concentrations in air were relatively high ~420 ± 320 (50-1000) an…

Mediterranean climateSettore BIO/07 - EcologiaPolybrominated biphenyl010504 meteorology & atmospheric sciencesHealth Toxicology and Mutagenesis010501 environmental sciencesMediterranean01 natural sciencesMediterranean BasinIslandAir back trajectorieAtmospherechemistry.chemical_compoundPolychlorinated BiphenylHalogenated Diphenyl EthersHydrocarbons ChlorinatedEcotoxicologyEnvironmental ChemistryPesticidesSicily0105 earth and related environmental sciencesPollutantIslandsAir PollutantsPUF diskAtmosphereMediterranean RegionGeneral MedicinePesticidePolychlorinated BiphenylsPollutionPassive samplerThe Island of sicilyPesticidechemistryAir PollutantHalogenated Diphenyl EtherEnvironmental chemistryEnvironmental scienceLindaneEnvironmental Monitoring
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Brominated flame retardants and toxic elements in the meat and liver of red deer (Cervus elaphus), wild boar (Sus scrofa), and moose (Alces alces) fr…

2017

In order to evaluate the contamination status of terrestrial biota in Latvia, muscle and liver tissues of red deer (Cervus elaphus), wild boar (Sus scrofa), and moose (Alces alces) were analyzed for the content of polybrominated diphenyl ethers (PBDE), hexabromocyclododecane (HBCD), tetrabromobisphenol A (TBBPA), as well as cadmium and lead. The highest mean concentrations of PBDEs (46.6pgg-1 wet weight (w.w.)), cadmium (0.95mgkg-1 w.w.), and lead (0.22mgkg-1 w.w.) were observed in the tissues of moose, while the wild boar samples contained the highest levels of HBCD, with the mean concentration equal to 264pgg-1 w.w. in muscle tissues. Generally low mean concentrations of TBBPA from 0.52 t…

Muscle tissueEnvironmental EngineeringPolybrominated BiphenylsSus scrofa0211 other engineering and technologiesZoologychemistry.chemical_element02 engineering and technology010501 environmental sciencesBiology01 natural scienceschemistry.chemical_compoundPolybrominated diphenyl ethersWild boarbiology.animalmedicineHalogenated Diphenyl EthersEnvironmental ChemistryAnimalsWaste Management and Disposal0105 earth and related environmental sciencesFlame RetardantsHexabromocyclododecane021110 strategic defence & security studiesCadmiumDeerPollutionLatviaHydrocarbons BrominatedRed Meatmedicine.anatomical_structureCongenerchemistryLiverBioaccumulationTetrabromobisphenol AEnvironmental MonitoringThe Science of the total environment
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Design of experiment approach for the optimization of polybrominated diphenyl ethers determination in fine airborne particulate matter by microwave-a…

2015

Abstract A sensitive and selective procedure for the determination of 12 polybrominated diphenyl ethers (BDE-28, BDE-49, BDE-47, BDE-66, BDE-100, BDE-119, BDE-99, BDE-155, BDE-154, BDE-153, BDE-139 and BDE-183) in airbone particulate matter (PM2.5) at trace level has been developed. The proposed method includes extraction PM2.5-bound PBDEs by microwave-assisted extraction (MAE) followed by gel permeation chromatography (GPC) clean-up and determination by GC-MS/MS using a programmed temperature vaporizer (PTV) in large volume injection (LVI) mode to introduce the sample to the chromatographic system. A design of experiment (DoE) approach was used for the optimization of large volume injectio…

PBDEsAnalytical chemistryPM2.5Tandem mass spectrometryBiochemistryMicrowave assisted extraction (MAE);Gas Chromatography-Mass SpectrometryAnalytical ChemistryGel permeation chromatographyPolybrominated diphenyl ethersTandem Mass SpectrometryHalogenated Diphenyl EthersMicrowavesDetection limitProgrammed temperature vaporizer (PTV)ChromatographyChemistryOrganic ChemistryExtraction (chemistry)TemperatureGeneral MedicineVolume (thermodynamics)SpainParticulate MatterVaporizerGas chromatographyGC-MS/MS; Experimental designJournal of chromatography. A
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Trimeric Hemibastadin Congener from the Marine Sponge Ianthella basta

2012

The first naturally occurring trimeric hemibastadin congener, sesquibastadin 1 (1), and the previously reported bastadins 3, 6, 7, 11, and 16 (2-6) were isolated from the marine sponge Ianthella basta, collected in Indonesia. The structure of 1 was elucidated on the basis of 1D and 2D NMR measurements and by HRMS. Among all the isolated compounds, the linear sesquibastadin 1 (1) and bastadin 3 (2) showed the strongest inhibition rates for at least 22 protein kinases (IC(50) = 0.1-6.5 μM), while the macrocyclic bastadins (3-6) demonstrated a strong cytotoxic potential against the murine lymphoma cell line L5178Y (IC(50) = 1.5-5.3 μM).

StereochemistryPharmaceutical ScienceMarine BiologySesquibastadinAnalytical ChemistryMiceIanthella bastaDrug DiscoveryHalogenated Diphenyl EthersAnimalsNuclear Magnetic Resonance BiomolecularProtein Kinase InhibitorsPharmacologyMolecular StructurebiologyMurine lymphomaOrganic Chemistrybiology.organism_classificationPoriferaSpongeCongenerComplementary and alternative medicineIndonesiaMolecular MedicineDrug Screening Assays AntitumorTwo-dimensional nuclear magnetic resonance spectroscopyJournal of Natural Products
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Effect of cropping cycles and repeated herbicide applications on the degradation of diclofop-methyl, bentazone, diuron, isoproturon and pendimethalin…

2002

A greenhouse study was conducted to investigate the ability of four crops (wheat, corn, oilseed rape and soybean) to influence the degradation of bentazone, diclofop-methyl, diuron, isoproturon and pendimethalin in soil. The present study showed that microbial biomass-carbon was significantly higher in planted soils than in bulk soil, especially with wheat and corn, after several cropping cycles. The biomass in corn and soybean planted soils was adversely affected by bentazone but recovered after three cropping cycles. In wheat-planted soils, diclofop-methyl application resulted in persistent increase of the amount of microbial biomass. Bentazone did not show accelerated degradation even af…

[SDE] Environmental SciencesCrops Agricultural[SDV]Life Sciences [q-bio]Bulk soil010501 environmental sciencesBenzothiadiazinescomplex mixtures01 natural scienceschemistry.chemical_compoundSoilHalogenated Diphenyl EthersBiomassCarbon RadioisotopesComputingMilieux_MISCELLANEOUSSoil Microbiology0105 earth and related environmental sciences2. Zero hungerCambisolRhizosphereMethylurea CompoundsMineralsAniline CompoundsBacteriaChemistryHerbicidesPhenyl EthersPhenylurea Compoundsfungifood and beveragesAgriculture04 agricultural and veterinary sciencesGeneral MedicineMineralization (soil science)15. Life on landPesticideCarbon DioxideEnvironment Controlled[SDV] Life Sciences [q-bio]PendimethalinKineticsAgronomyInsect ScienceDiuronSoil water[SDE]Environmental Sciences040103 agronomy & agriculturePesticide degradation0401 agriculture forestry and fisheriesAgronomy and Crop SciencePest management science
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Method optimization to measure polybrominated diphenyl ether (PBDE) concentrations in soils of Bratislava, Slovakia.

2010

We modified an analytical method to determine polybrominated diphenyl ethers (PBDEs) in urban soils of Bratislava (Slovakia). Gel permeation chromatography (GPC) introduced as a clean-up step for soil extracts substantially reduced matrix enhancements when PBDEs were measured with gas chromatography-negative chemical ionization-mass spectrometry (GC-NCI-MS). The resulting method proved to be accurate, precise, and showed low detection limits. The sum of 15 PBDE concentrations in surface horizons of Bratislava soils ranged from 87 to 627 pg g(-1). PBDE concentrations were mostly higher in surface than deeper horizons probably because of atmospheric deposition and lack of substantial vertical…

endocrine systemSlovakiaSoil testHealth Toxicology and MutagenesisToxicologyGas Chromatography-Mass Spectrometrychemistry.chemical_compoundSoilPolybrominated diphenyl ethersHalogenated Diphenyl EthersSoil Pollutantsreproductive and urinary physiologyChromatographySoil organic matterDiphenyl etherUrbanizationReproducibility of ResultsSoil classificationGeneral MedicineReference StandardsPollutionSoil contaminationhumanitieschemistryEnvironmental chemistrySoil waterChromatography GelPolybrominated BiphenylsEnvironmental MonitoringEnvironmental pollution (Barking, Essex : 1987)
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