Search results for "Han"
showing 10 items of 32320 documents
PTC124-mediated translational readthrough of a nonsense mutation causing Usher syndrome type 1C.
2011
We investigated the therapeutic potential of the premature termination codon (PTC) readthrough-inducing drug PTC124 in treating the retinal phenotype of Usher syndrome, caused by a nonsense mutation in the USH1C gene. Applications in cell culture, organotypic retina cultures, and mice in vivo revealed significant readthrough and the recovery of protein function. In comparison with other readthrough drugs, namely the clinically approved readthrough-inducing aminoglycoside gentamicin, PTC124 exhibits significant better retinal biocompatibility. Its high readthrough efficiency in combination with excellent biocompatibility makes PTC124 a promising therapeutic agent for PTCs in USH1C, as well a…
On the Dynamics of Fractional Visco-Elastic Beams
2012
With increasing advanced manufacturing process, visco-elastic materials are very attractive for mitigation of vibrations, provided that you may have advanced studies for capturing the realistic behavior of such materials. Experimental verification of the visco-elastic behavior is limited to some well-known low order models as the Maxwell or Kelvin models. However, both models are not sufficient to model the visco-elastic behavior of real materials, since only the Maxwell type can capture the relaxation tests and the Kelvin the creep tests, respectively. Very recently, it has been stressed that the most suitable model for capturing the visco-elastic behavior is the spring-pot, characterized …
The ALICE experiment at the CERN LHC
2008
Journal of Instrumentation 3(08), S08002 (2008). doi:10.1088/1748-0221/3/08/S08002
Toimijuus korkeakoulutettujen suomen oppijoiden visuaalisissa narratiiveissa
2018
This socioculturally informed study explores how highly educated Finnish language learners represent their agency in visual narratives. Learners (n=59) were asked to draw two pictures of themselves as Finnish language users and provide verbal interpretations of the drawings. The aim of using visual narratives is to reach aspects such as feelings and beliefs which might be difficult to express verbally. The data were analyzed first by using visual grammar set out by Kress and van Leeuwen (2006) and secondly by content analysis. The findings suggest that learners saw Finnish language as a tool for oral communication. However, difficulties with speaking and listening appeared to restrict learn…
Toimijuus korkeakoulutettujen suomen oppijoiden visuaalisissa narratiiveissa
2018
This socioculturally informed study explores how highly educated Finnish language learners represent their agency in visual narratives. Learners (n=59) were asked to draw two pictures of themselves as Finnish language users and provide verbal interpretations of the drawings. The aim of using visual narratives is to reach aspects such as feelings and beliefs which might be difficult to express verbally. The data were analyzed first by using visual grammar set out by Kress and van Leeuwen (2006) and secondly by content analysis. The findings suggest that learners saw Finnish language as a tool for oral communication. However, difficulties with speaking and listening appeared to restrict learn…
Virskorekcijas pielietojamība tuvredzības progresijas novērtēšanā ortokeratoloģijas pacientiem
2022
Darbs ir uzrakstīts angļu valodā uz 93 lapaspusēm. Tas satur 49 attēlus, 24 tabulas un 95 atsauces uz literatūras avotiem. Šī darba mērķis ir pārbaudīt, vai virskorekcija ir derīga metode tuvredzības progresēšanas novērtēšanai ortokeratoloģijā. Hipotēze ir atrast lielākas izmaiņas gados jaunākiem pacientiem nekā pieaugušajiem, kā tas ir norādīts literatūrā. Pētījumā iekļauti 192 Eiropeīdās rases subjekti vecumā no 6 līdz 56 gadiem (vidēji 19,61±10,30). Izmantojot retrospektīvu analīzi, no objektīva BOZR kontaktlēcas parametra tiek iegūta virskorekcija (ORX). Jaunākiem cilvēkiem ir lielākas ORX vērtības, bet pieaugušajiem nav atšķirības (p<0,05). Vidēji tuvredzība progresēja par –0,18±0,44 D…
Cluster visual field progression and its relationship with optic disc changes
2015
Purpose Glaucoma diagnosis and follow up of progression is often based on structural and functional assessments. This study aimed to assess clustered progression and evaluate its correlation with the corresponding disc changes (RA sectors) obtained from HRT examinations. Methods 51 eyes from OHT and glaucoma patients with a minimum of 5 reliable visual ᴀ밄eld tests (HFA II i 24-2) and HRT with a follow-up >4 years were analyzed retrospectively. Linear regression of clusters deᴀ밄ned by the Glaucoma Hemiᴀ밄eld Test (GHT) was performed based on the mean threshold in each cluster. Global and sectoral rates of change in RAs were assessed and correlated with functional clustered measures. Cluste…
Development and characterisation of polymer composite materials with bio-inspired functions
2018
Promocijas darbs ir izstrādāts disertācijas veidā fizikas nozarē materiālu fizikas apakšnozarē. Pētījums tika veikts LU Materiālu mehānikas institūtā. Darbs saistīts ar aktuālu un jaunu pētījumu virzienu: bioinspirēto funkciju tālāku attīstīšanu slodzi nesošos kompozītos. Tās ir mehānisku triecienu vizuālās indikācijas un polimēru matricas vaskulārās pašdziedināšanas funkcijas. Šīs funkcijas tika nodrošinātas, izveidojot viedus slāņus un iebūvējot tos kompozītā. Pētījumā tika noskaidrotas piemērotās pārbaužu secības, attīstītas kvantitatīvas metodes un mehānisks modelis, lai novērtētu jauno funkciju efektivitāti kompozītos. Ir pierādīta funkciju augstā efektivitāte un spēja uzlabot slodzi n…
Editorial : Visual mismatch negativity (vMMN) : A unique tool in investigating automatic processing
2022
Explicit behavioral detection of visual changes develops without their implicit neurophysiological detectability
2011
Change blindness is a failure of reporting major changes across consecutive images if separated, e.g., by a brief blank interval. Successful change detection across interrupts requires focal attention to the changes. However, findings of implicit detection of visual changes during change blindness have raised the question of whether the implicit mode is necessary for development of the explicit mode. To this end, we recorded the visual mismatch negativity (vMMN) of the event-related potentials (ERPs) of the brain, an index of implicit pre-attentive visual change detection, in adult humans performing an oddball-variant of change blindness flicker task. Images of 500 ms in duration were prese…