Search results for "Hanging"
showing 10 items of 104 documents
Cytotoxicity of cardiotonic steroids in sensitive and multidrug-resistant leukemia cells and the link with Na(+)/K(+)-ATPase.
2015
Cardiotonic steroids have long been in clinical use for treatment of heart failure and are now emerging as promising agents in various diseases, especially cancer. Their main target is Na(+)/K(+)-ATPase, a membrane protein involved in cellular ion homeostasis. Na(+)/K(+)-ATPase has been implicated in cancer biology by affecting several cellular events and signaling pathways in both sensitive and drug-resistant cancer cells. Hence, we investigated the cytotoxic activities of 66 cardiotonic steroids and cardiotonic steroid derivatives in sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells. Data were then subjected to quantitative structure-activity relationship analysis (QSA…
Effect of a hyperlipidic diet on lipid composition, fluidity, and (Na+-K+)ATPase activity of rat erythrocyte membranes.
1989
Feeding rats a hyperlipidic diet in which animals were offered daily a variety of high-energy food resulted in a significant increase of serum free fatty acids and a decrease of phospholipids with respect to controls. On the contrary, there were no significant differences in erythrocyte membrane total lipid composition between the two groups. Erythrocyte membranes showed a significant decrease in saturated fatty acid content and a significant increase in (n-6) polyunsaturated fatty acid content; (n-3) polyunsaturated fatty acids significantly decreased. Membrane fluidity, investigated by fluorescence polarization of diphenylhexatriene, significantly increased in the erythrocyte membranes of…
Multiple solutions for quasilinear elliptic problems via critical points in open sublevels and truncation principles
2012
Abstract We study a quasilinear elliptic problem depending on a parameter λ of the form − Δ p u = λ f ( u ) in Ω , u = 0 on ∂ Ω . We present a novel variational approach that allows us to obtain multiplicity, regularity and a priori estimate of solutions by assuming certain growth and sign conditions on f prescribed only near zero. More precisely, we describe an interval of parameters λ for which the problem under consideration admits at least three nontrivial solutions: two extremal constant-sign solutions and one sign-changing solution. Our approach is based on an abstract localization principle of critical points of functionals of the form E = Φ − λ Ψ on open sublevels Φ − 1 ( ] − ∞ , …
A survey on pseudonym changing strategies for Vehicular Ad-Hoc Networks
2017
International audience; The initial phase of the deployment of vehicular ad-hoc networks (VANETs) has begun and many research challenges still need to be addressed. Location privacy continues to be in the top of these challenges. Indeed, both academia and industry agreed to apply the pseudonym changing approach as a solution to protect the location privacy of VANETs' users. However, due to the pseudonyms linking attack, a simple changing of pseudonym shown to be inefficient to provide the required protection. For this reason, many pseudonym changing strategies have been suggested to provide an effective pseudonym changing. Unfortunately, the development of an effective pseudonym changing st…
Observation of Photon Polarization in theb→sγTransition
2014
This Letter presents a study of the flavor-changing neutral current radiative $B^{\pm} \to K^{\pm}\pi^{\mp}\pi^{\pm}\gamma$ decays performed using data collected in proton-proton collisions with the LHCb detector at $7$ and $8\,$TeV center-of-mass energies. In this sample, corresponding to an integrated luminosity of $3\,\text{fb}^{-1}$, nearly $14\,000$ signal events are reconstructed and selected, containing all possible intermediate resonances with a $K^{\pm}\pi^{\mp}\pi^{\pm}$ final state in the $[1.1, 1.9]\,$GeV/$c^{2}$ mass range. The distribution of the angle of the photon direction with respect to the plane defined by the final-state hadrons in their rest frame is studied in interva…
Femtosecond time resolved coherent anti-Stokes Raman spectroscopy: Experiment and modelization of speed memory effects on H2-N2 mixtures in the colli…
2005
194317; With the aim of temperature diagnostic, femtosecond time-resolved CARS (coherent anti-Stokes Raman spectroscopy) is applied to probe H2 in H2-N2 mixtures. In a first part, a Lorentzian profile is used to model the femtosecond CARS response. A difference between the experimental broadening and the expected one is observed in the collision regime. The observed broadening increases strongly in an inhomogeneous way with respect to the perturber concentration. This is of considerable importance for temperature measurements. In a second part, we show that in the collision regime, this inhomogeneous broadening is due to the speed dependence of the collisional parameters and the memory effe…
Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countr…
2015
Summary Background The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age–sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic develo…
Effects of repeated short episodes of environmental acidification on Atlantic salmon (Salmo salar) from a landlocked population
2020
Abstract Chronic or repeated exposure to environmental contaminants may result in allostatic overload, a physiological situation in which the costs of coping affect long-term survival and reproductive output. Continuous measurements in Otra, the largest river in southern Norway, show the occurrence of repeated 24–48 h episodes of acidification. This work investigates the impact of repeated short acidification episodes on a unique land-locked population of normally anadromous Atlantic salmon (“Bleke”). This was done by recording physiological measures of stress and allostatic load in fish exposed for 7 days to continuous or repeated episodes of simulated environmental acidification or untrea…
Attenuated Carbohydrate and Gill Na+ , K+-ATPase Stress Responses in Whitefish Caged near Bleached Kraft Mill Discharges
2002
Exposure to biologically treated bleached kraft mill effluent (BKME) is demonstrated to greatly modify the acute physiological stress response in fish and, accordingly, to lead to inconsistencies in data interpretation due to dissimilar effects of handling procedures on reference and exposed fish. To consider this phenomenon, juvenile whitefish (Coregonus lavaretus) were caged for 30 days in four reference sites and in three areas influenced by different BKME discharges. After exposure, fish were subjected to the impacts of low-level handling by raising the cages to the water surface, serially handnetting the fish, and transferring ( approximately 10 min) the submerged cages to the research…
Cadmium, mercury, and lead effects on gill tissue of freshwater crayfishProcambarus clarkii (girard)
1989
Intermolt adult crayfish P. clarkii were used for this work. After acclimatization to laboratory conditions crayfish were exposed to sublethal concentrations of cadmium, mercury, and lead for 96 h. Gills of control and exposed crayfish were removed and ATPase activity and oxygen uptake rate were determined. Structural damage of gill filaments was also observed. Gill tissue respiration rates were measured for individual crayfish using a Gilson differential respirometer. Lead causes a decrease of gill oxygen uptake, but neither cadmium nor mercury seems to affect it at the concentrations employed. Although all metals studied alter gill filament structure, lead damage is the most apparent. In …