Search results for "Harringtonines"

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Conventional induction and post-remission therapy in APL: have we arrived?

2014

Since the introduction of all-trans-retinoic acid, the use of this molecularly targeted treatment in combination with anthracycline-based chemotherapy has completely changed the prognosis of acute promyelocytic leukemia (APL) turning it into the most curable acute myeloid leukemia. Also, the use of risk-adapted protocols has optimized the drug combination and the most appropriate dose intensity for each subset of patients classified according to both risk of relapse and vulnerability to drug toxicity. Recent developments have included the investigation of the role of arsenic trioxide (ATO) as front-line treatment after its success in relapsed APL, both to minimize or even omit the use of cy…

OncologyAcute promyelocytic leukemiaDrugmedicine.medical_specialtyHarringtoninesAnthracyclinemedia_common.quotation_subjectmedicine.medical_treatmentClinical BiochemistryTretinoinPharmacologyArsenicalsTargeted therapyMaintenance Chemotherapychemistry.chemical_compoundArsenic TrioxideLeukemia Promyelocytic AcuteInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansMulticenter Studies as TopicAnthracyclinesRelapse riskArsenic trioxidemedia_commonChemotherapyClinical Trials as Topicbusiness.industryMercaptopurineDaunorubicinRemission InductionMyeloid leukemiaOxidesmedicine.diseaseConsolidation ChemotherapyMethotrexateOncologychemistryMitoxantronebusinessHomoharringtonineIdarubicinBest practiceresearch. Clinical haematology
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