Search results for "Hazard"
showing 10 items of 1517 documents
Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients.
2006
Abstract Background: Impaired DNA repair capacity may favorably affect survival in cisplatin/gemcitabine-treated non-small-cell lung cancer (NSCLC) patients. We investigated the association of survival with genetic polymorphisms in X-ray repair cross-complementing group 1 and group 3 (XRCC3), xeroderma pigmentosum group D (XPD), excision repair cross-complementing group 1, ligase IV, ribonucleotide reductase, TP53, cyclooxygenase-2, interleukin-6, peroxisome proliferator-activated receptor γ, epidermal growth factor, methylene-tetra-hydrofolate reductase and methionine synthase. Patients and methods: One hundred and thirty-five stage IV or IIIB (with malignant pleural effusion) NSCLC patien…
317 Role of integrins in the metastatic spread of high-grade serous ovarian cancer
2021
Introduction/Background* In high-grade serous ovarian cancer (HGSOC) an early intraperitoneal metastatic spread is common which determines the therapeutical approach and prognosis. Integrins may be involved in metastatic spread of HGSOC. In this study, integrin expression was examined in primary tumour and metastases of HGSOC. Methodology The expression of integrin α2, α4, α5, α6, and β1 was assessed by immunostaining in tumour samples of the ovary, omentum, and peritoneum of each patient. Differences in integrin expression among tumour localisations and their association with clinicopathological parameters were examined by Fisher’s exact test. The impact of integrin expression on progressi…
Climats tropicaux d'aujourd'hui à demain : variabilité et changements
2008
Present and future tropical climates : their climate variability and their climate changes The oriffttality of tropical climates is re-examined under the light of climate variability and climate change, both present and future . The interannual variability of rainfall is on average larger in the tropics than in the extra-tropics, but it is also spatially more contrasted. Human communities have often responded to this constraint through efficient coping strategies. The regions showing the most variable climate do not necessarily have lower population densities, an indication that in the long run variability is not decisive. However, the recent demographic growth of these regions is often low…
How abrupt change in surface temperature impacts water balance over France? A case-study of bread wheat cultivated areas.
2022
Agricultural risk management is a major challenge for decision makers, public authorities and agricultural insurance companies, as crop losses linked to climate hazard are expected to increase in the context of climate change (Boucher et al., 2019). The present work is part of a PhD in partnership between Groupama insurance company (Domaine Assurance Récolte) and Biogeosciences laboratory (University of Burgundy). This collaborative research aims at depicting how, with the abrupt surface temperature warming, climate hazard evolution has affected water balance over France, and related agro-climatic risks.Since 1980s over western Europe, the warming trend intensifies strongly, consistent with…
Functionnalized Surface Acoustic Wave Sensors for the Detection of Hazardous Gases
2018
International audience; In this work, we show the capabilities of Surface Acoustic Wave (SAW) devices to probe the properties of gas sensitive materials for the manufacturing of hazardous gas sensors. The great capabilities of cobalt corroles for the trapping of carbon monoxide (CO) were exploited to produce selective sensors. These corroles were deposited on SAW delay lines surfaces and then exposed to carbon monoxide (CO) in standard conditions. Concentrations of a few hundreds of ppb were measured emphasizing the interest of such sensors for the detection of CO. Another type of sensitive layers exhibiting specific porosity adapted to the trapping of formaldehyde (CH$_2$O) were deposited …
Goodness-of-fit tests for parametric excess hazard rate models with covariates
2017
In this paper we propose a general methodology for testing the null hypothesis that an excess hazard rate model, with or without covariates, belongs to a parametric family. Estimating the excess hazard rate function parametrically through the maximum likelihood method and non-parametrically (or semi-parametrically) we build a discrepancy process which is shown to be asymptotically Gaussian under the null hypothesis. Based on this result we are able to build some statistical tests in order to decide wether or not the null hypothesis is acceptable. We illustrate our results by the construction of chi-square tests which the behavior is studied through a Monte-Carlo study. Then the testing proc…
Coseismic extension recorded within the damage zone of the Vado di Ferruccio Thrust Fault, Central Apennines, Italy
2018
Recent high resolution hypocentral localisation along active fault systems in the Central Apennines illuminates the activation of seismogenic volumes dipping at low angle (<30°) in extensional settings overprinting contractional deformations affecting the continental crust of the Adria microplate. Individuation of the geological structures and of the fault processes associated with these seismic patterns will contribute to the interpretation of seismic sequence evolution, and seismic hazard studies.Here we report field and microstructural evidence of seismogenic extensional faults localized within pre-existing thrust fault zones. The Vado di Ferruccio Thrust Fault (VFTF) is a narrow …
Zilās gaismas draudu kumulatīvā analīze
2022
Maģistra darbs uzrakstīts angļu valodā uz 42 lappusēm. Tas satur 15 attēlus, 4 vienadojumi, 8 tabulas un 64 atsauces. Cilvēki katru dienu ir pakļauti zilajai gaismai. Zilā gaisma ir bīstama, ja tā pārsniedz 100 J / (cm2-sr) uz 106 ≤ t. Pirmsreceptoru makulas pigmenti, luteīns un zeaksantīns kopā ar lēcas kristālu absorbē zilo gaismu. Zilās gaismas svērtais spožums dažādos ekspozīcijas ilgumos tika modelēts ar doto datu bāzi, kas ņemta no f. fluxometrs dažādiem zilās gaismas avotiem. Rezultāti parādīja, ka gaismai, ko izstaro saules gaisma, īpaši saulainās dienās, ir visaugstākās zilās gaismas spožuma vērtības un tā tiek uzskatīta par kaitīgu, bet tomēr nepārsniedz vērtības, kas pierāda bīst…
<p>A Country Pandemic Risk Exposure Measurement Model</p>
2020
Purpose: The purpose of this study is to develop a Pandemic Risk Exposure Measurement (PREM) model to determine the factors that affect a country’s prospective vulnerability to a pandemic risk exposure also considering the current COVID-19 pandemic Methods: To develop the model, drew up an inventory of possible factor variables that might expose a country’s vulnerability to a pandemic such as COVID-19 This model was based on the analysis of existing literature and consultations with some experts and associa-tions To support the inventory of selected possible factor variables, we have conducted a survey with participants sampled from people working in a risk management environment carrying o…
Masonry structures subjected to tsunami loads: Modeling issues and application to a case study
2020
Abstract Tsunamis are among the most dangerous natural disasters for coastal areas experiencing tsunami hazard. One of the major concerns in the assessment of strategies for the risk mitigation is to estimate vulnerability of structures and infrastructures. However, reliable approaches for the evaluation of the structural capacity under tsunami loads are nowadays not always available for all the types of structures, especially masonry. On this aim, the paper deals with the modeling issues of 3D masonry structures subjected to tsunami loads and the effect on the structural behavior of different modeling approaches. First, a brief state of the art on the available studies is presented regardi…