Search results for "Head and Neck"

Non-invasive diagnosis of oral cancer: The role of electro-analytical methods and nanomaterials

2017

Abstract Oral cancer is a kind of head and neck cancer and is each cancerous tissue growth located in the oral cavity. Non-invasive early diagnosis of oral cancer is the most effective means to reduce death from this disease or increase the survival time. In this review, various types of electro-analytical methods for detection of oral cancer were discussed. The emphasis is placed on non-invasive detection of oral based on immune-, geno-, cyto-, apta-, and enzyme-biosensing strategies. In the first part of review, various electrochemical immunosensing methods for the detection of common biomarker in oral cancer and examines their potential as a new method were discussed. In the second part …

PCN378 - MINIMALLY IMPORTANT DIFFERENCES FOR INTERPRETING EORTC QLQ-C30 SCORES IN MELANOMA, BREAST CANCER AND HEAD AND NECK CANCER PATIENTS ON BEHALF…

2018

Preoperative Radiochemotherapy and Radical Surgery of Advanced Head and Neck Cancers — Results of a Prospective, Multicenter DÖSAK Study

1994

Present research concerning the efficiacy of therapeutic strategies for squamous cell carcinomas of the oral cavity and the oropharynx profits from former observational studies. The so-called retrospective German, Austrian, and Swiss Association for Head and Neck Tumors (DOSAK) study (Platz et al. 1986) served to review existing proposals for classification (UICC 1973, 1978; AJC 1978) and to develop a statistical classification which enables the head and neck oncologist to define prognostically homogeneous patient collectives. The treatment-dependent prognostic index (TPI) was the corresponding result (Platz et al. 1982).

Erythropoietin to treat anaemia in patients with head and neck cancer

2004

based on the improvement of tumour oxygenation through direct effects (oxygen enhancement effect of radiotherapy) and indirect effects (counteraction of the adverse influence of tumour hypoxia on malignant progression), only increases in haemoglobin concentration that result in improvements in tumour oxygenation can be expected to have a favourable effect on prognosis. The haemoglobin concentration range leading to the highest tumour oxygen levels is most probably between 130 and 140 g/L, since this concentration represents an optimum in terms of the counteracting effects of increasing the blood’s oxygen-carrying capacity and rising viscous resistance to flow. At higher haemoglobin concentr…

Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study

2021

Background The search for treatments to improve cancer survival has led to the emergence of immunotherapy and the study of the tumour microenvironment existing in neoplasms. This preliminary study aims to understand the clinical and pathological relationship of clec9a expression in oral cancer and to explore survival models for future studies. Material and methods: Immunohistochemical study that included 26 patients with a diagnosis of oral squamous cell carcinoma (OSCC) in mobile tongue and floor of the mouth. Clinical and histopathological variables were recorded, and the biomarkers clec9a for dendritic cells and CD8 and CD4 for lymphocytes were used. Results Clec9a was expressed in 58% o…

Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study

2019

Background Radiation-related caries (RRC) is one of the most significant oral toxicities of head and neck radiotherapy (HNRT); however, the potential of radiation to directly cause harmful dentin and pulpal effects and impair response to caries progression is controversial. Material and Methods Therefore, the aim of this study was to characterize the reactions of the dentin-pulp complex in teeth affected by RRC. Patients and methods: Twenty-two carious teeth extracted from 22 head and neck cancer (HNC) patients were divided into control (conventional caries; n=11) and irradiated (RRC; n=11) groups and paired matched by dental homology, clinical patterns of caries progression following the P…

Dental approach of orofacial pain in head and neck cancer patients

2018

Background Orofacial pain (OFP) is an undesirable sensation frequently associated with head and neck cancer (HNC) and its treatment. OFP negatively impacts the quality of life of oncological patients. The approach to OFP diagnosis and management can differ if the patient visits a dentist or physician. The aim of this study was to present a case series of HNC with OFP managed by a dentist team and to discuss its role in the management of OFP. Material and methods We recruited twenty-two adult patients with OFP and previous diagnosis of HNC referred to an academic dental clinic from 2015 to 2017. Results Nociceptive was more frequent than mixed and neuropathic pain, however 54,4% of the cases…

Periodontal therapy for patients before and after radiotherapy : a review of the literature and topics of interest for clinicians

2018

Background To review and discuss important topics regarding periodontal treatment pre- and post-radiotherapy for head and neck cancer in human patients; to discuss the references for adequate techniques, the appropriate moment for tooth extractions and periodontal management; and to discuss the prevention of osteoradionecrosis. Material and Methods Thirty-nine studies including original studies, randomized clinical trials (RCTs) and reviews were searched in online databases MEDLINE (PubMed) and the Cochrane library. No year of publication restriction was applied. Results Language was restricted to English, and the following Medical Subject Heading terms were used: radiotherapy, radiation th…

Studie zur intraarteriellen Mono- und Polychemotherapie von Mundh�hlen- und Oropharynxkarzinomen: Methotrexat (MTX) im Vergleich zur Kombination Vinc…

1982

In einer vergleichenden Studie wurde bei Karzinomen der Mundhohle und des Oropharynx der zytostatische Effekt einer intraarteriellen Monotherapie mit Methotrexat (MTX) einer Polychemotherapie mit Vincristin-Methotrexat-Bleomycin-Cisplatin (VMBP) gegenubergestellt.

Ancient Schwannoma of the hard palate. An uncommon case report and review

2013

Schwannoma or neurilemmoma is an infrequent benign tumor in the oral cavity that originates from the Schwann cells on the neural sheath of the peripheral nerves. Schwannomas are frequently located in the soft tissues of head and neck region, but only a 1 to 12% of them are located in the oral cavity. Some histological variants of schwannoma have been described including the cellular, plexiform, epithelioid, ancient, and melanocytic types. The “ancient schwannoma” is an uncommon variant of this tumor that shows specific histological characteristics, and is rare in the oral cavity with less than 15 cases described on the literature. Most of them were located in the tongue or in the floor of t…