Search results for "Head and neck squamous cell carcinoma"

showing 5 items of 15 documents

Carboplatin in combination with raltitrexed in recurrent and metastatic head and neck squamous cell carcinoma: A multicentre phase II study of the Gr…

2005

ackground: The combination of cisplatin (CDDP) and 5-Fluorouracil (5-FU) is a standard regimen for the treatment of recurrent and metastatic head and neck squamous cell carcinoma (HNSCC). This combination shows a relevant toxicity and new chemotherapy associations with a more favourable toxicity profile are awaited. Carboplatin (CB) is a platinum derivative with less toxicity than CDDP. Raltitrexed (R) is a potent and specific thymidylate synthase inhibitor with activity comparable to that of 5-FU in colorectal cancer; moreover, it showed activity as a single agent in HNSCC. Materials and Methods: Since 2001, a multicentre, phase II trial has been underway to evaluate the efficacy and toxic…

RaltitrexedHead and neck squamous cell carcinomaCarboplatin
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Bioinformatics analysis of TP53 gene in head and neck squamous cell carcinoma patients from the cancer genome atlas

2019

TP53 gene head and neck squamous cell carcinoma
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MMP-10/stromelysin-2 promotes invasion of head and neck cancer.

2011

BackgroundPeriostin, IFN-induced transmembrane protein 1 (IFITM1) and Wingless-type MMTV integration site family, member 5B (Wnt-5b) were previously identified as the invasion promoted genes of head and neck squamous cell carcinoma (HNSCC) by comparing the gene expression profiles between parent and a highly invasive clone. We have previously reported that Periostin and IFITM1 promoted the invasion of HNSCC cells. Here we demonstrated that Wnt-5b overexpression promoted the invasion of HNSCC cells. Moreover, stromelysin-2 (matrix metalloproteinase-10; MMP-10) was identified as a common up-regulated gene among Periostin, IFITM1 and Wnt-5b overexpressing HNSCC cells by using microarray data s…

Tumor PhysiologyClone (cell biology)p38 Mitogen-Activated Protein KinasesMetastasisMetastasisMolecular Cell BiologyBasic Cancer ResearchNeoplasm MetastasisRegulation of gene expressionGene knockdownMultidisciplinaryHead and Neck cancerQRTransfectionHead and Neck TumorsExtracellular MatrixUp-RegulationGene Expression Regulation NeoplasticOncologyHead and Neck NeoplasmsGene Knockdown TechniquesCarcinoma Squamous CellMedicineResearch ArticleScience490Oral MedicineBiologyPeriostinHead and Neck Squamous Cell CarcinomaMatrix Metalloproteinase 10stomatognathic systemSettore MED/28 - Malattie OdontostomatologicheCell Line TumormedicineCancer Detection and Diagnosisotorhinolaryngologic diseasesHumansNeoplasm Invasiveness490BiologyExtracellular Matrix AdhesionsProtein Kinase InhibitorsneoplasmsMicroarray analysis techniquesCancers and Neoplasmsmedicine.diseaseMolecular biologyHead and neck squamous-cell carcinomaAntigens DifferentiationWnt Proteinsstomatognathic diseasesCancer researchCell Adhesion MoleculesPLoS ONE
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Head–Neck Cancer Delineation

2021

Head–Neck Cancer (HNC) has a relevant impact on the oncology patient population and for this reason, the present review is dedicated to this type of neoplastic disease. In particular, a collection of methods aimed at tumor delineation is presented, because this is a fundamental task to perform efficient radiotherapy. Such a segmentation task is often performed on uni-modal data (usually Positron Emission Tomography (PET)) even though multi-modal images are preferred (PET-Computerized Tomography (CT)/PET-Magnetic Resonance (MR)). Datasets can be private or freely provided by online repositories on the web. The adopted techniques can belong to the well-known image processing/computer-vision a…

medicine.medical_specialtyComputer sciencemedicine.medical_treatmentImage processinghead–neck cancer (HNC)Head neck cancerlcsh:Technology030218 nuclear medicine & medical imagingTask (project management)head and neck squamous cell carcinoma (HNSCC)lcsh:Chemistry03 medical and health sciencestumor delineation0302 clinical medicinemedicineGeneral Materials ScienceMedical physicsSegmentationlcsh:QH301-705.5InstrumentationSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniFluid Flow and Transfer Processesmedicine.diagnostic_testlcsh:Tbusiness.industryProcess Chemistry and TechnologyDeep learningsegmentationGeneral EngineeringCT Head and neck squamous cell carcinoma (HNSCC) Head–neck cancer (HNC) MRI Nasopharyngeal cancer (NPC) PET Segmentation Tumor delineationnasopharyngeal cancer (NPC)lcsh:QC1-999Computer Science ApplicationsRadiation therapylcsh:Biology (General)lcsh:QD1-999lcsh:TA1-2040Positron emission tomography030220 oncology & carcinogenesisArtificial intelligenceTomographylcsh:Engineering (General). Civil engineering (General)businesslcsh:PhysicsCTApplied Sciences
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Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma

2017

Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous and aggressive tumor originating from the epithelial lining of the upper aero-digestive tract accounting for 300,000 annual deaths worldwide due to failure of current therapies. The natural killer group 2D (NKG2D) receptors on natural killer (NK) cells and several T cell subsets play an important role for immunosurveillance of HNSCC and are thus targeted by tumor immune evasion strategies in particular by shedding of various NKG2D ligands (NKG2DLs). Based on plasma and tumor samples of 44 HNSCC patients, we found that despite compositional heterogeneity the total plasma level of NKG2DLs correlates with NK cell inhibitio…

medicine.medical_treatmentT cellImmunologyadsorption apheresisimmunotherapy of cancerBiologynatural killer group 2D ligandshead and neck squamous cell carcinomaNatural killer cell03 medical and health sciencestumor immune escape0302 clinical medicineCancer immunotherapymedicineImmunology and AllergyOriginal ResearchLymphokine-activated killer cellnatural killer cellsNKG2Dmedicine.diseasePrimary tumorHead and neck squamous-cell carcinomaImmunosurveillancestomatognathic diseasesmedicine.anatomical_structure030220 oncology & carcinogenesisImmunology030215 immunologyFrontiers in Immunology
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