Search results for "Head and neck squamous-cell carcinoma"

showing 2 items of 52 documents

Treatment patterns in older patients with locally advanced head and neck squamous cell carcinoma

2021

OBJECTIVES: We aimed to assess patterns of care delivered to older patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC), and to analyze the use of geriatric assessment (GA) and assessment of quality of life (QoL).MATERIALS AND METHODS: Members of the head and neck cancer group and the older task force of the European Organisation for Research and Treatment of Cancer (EORTC), members the European Head and Neck Society and members of national groups in Europe were asked to complete a questionnaire about treatment delivered, use of GA, and QoL assessment in older patients with LA-HNSCC.RESULTS: Investigators from 111 centers replied, including 90 (81.1%) academic cen…

medicine.medical_specialtyLocally advancedMEDLINE03 medical and health sciences0302 clinical medicineQuality of lifeSurveys and QuestionnairesmedicineHumans030212 general & internal medicineProspective cohort studyAgedbusiness.industrySquamous Cell Carcinoma of Head and NeckHead and neck cancerCancermedicine.diseaseHead and neck squamous-cell carcinomaCANCERhumanitiesOncologyOropharyngeal CarcinomaHead and Neck Neoplasms030220 oncology & carcinogenesisPhysical therapyCarcinoma Squamous CellQuality of LifeGeriatrics and GerontologybusinessJournal of Geriatric Oncology
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Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma

2017

Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous and aggressive tumor originating from the epithelial lining of the upper aero-digestive tract accounting for 300,000 annual deaths worldwide due to failure of current therapies. The natural killer group 2D (NKG2D) receptors on natural killer (NK) cells and several T cell subsets play an important role for immunosurveillance of HNSCC and are thus targeted by tumor immune evasion strategies in particular by shedding of various NKG2D ligands (NKG2DLs). Based on plasma and tumor samples of 44 HNSCC patients, we found that despite compositional heterogeneity the total plasma level of NKG2DLs correlates with NK cell inhibitio…

medicine.medical_treatmentT cellImmunologyadsorption apheresisimmunotherapy of cancerBiologynatural killer group 2D ligandshead and neck squamous cell carcinomaNatural killer cell03 medical and health sciencestumor immune escape0302 clinical medicineCancer immunotherapymedicineImmunology and AllergyOriginal ResearchLymphokine-activated killer cellnatural killer cellsNKG2Dmedicine.diseasePrimary tumorHead and neck squamous-cell carcinomaImmunosurveillancestomatognathic diseasesmedicine.anatomical_structure030220 oncology & carcinogenesisImmunology030215 immunologyFrontiers in Immunology
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