Search results for "Head"

Interactions texture-flaveur : mécanismes physico-chimiques ou mécanismes cognitifs ? Application à un gel laitier onctueux

2006

Texture, taste and aroma are key components of the perceived quality of foodstuffs. Many studies showed that modifying one of thèse dimensions could modify the perception of another one. However it is not always clear whether thèse interactions could be attributed to physico-chemical or cognitive mechanisms. The présent work aimed at studying sensory interactions between texture, taste and aroma, in relation with the perception of creaminess, an indicator of food quality. A first step consisted in defining the creaminess concept using sensory and verbal approaches. This study highlighted three groups of consumers: creaminess was associated to texture for the first group, to texture and tast…

Effect of the Parotid Function on the Dental Health after Radiotherapy of the Head and Neck Region

2005

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine.

2019

International audience; AGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been obser…

End-to-end tests using alanine dosimetry in scanned proton beams

2018

This paper describes end-to-end test procedures as the last fundamental step of medical commissioning before starting clinical operation of the MedAustron synchrotron-based pencil beam scanning (PBS) therapy facility with protons. One in-house homogeneous phantom and two anthropomorphic heterogeneous (head and pelvis) phantoms were used for end-to-end tests at MedAustron. The phantoms were equipped with alanine detectors, radiochromic films and ionization chambers. The correction for the 'quenching' effect of alanine pellets was implemented in the Monte Carlo platform of the evaluation version of RayStation TPS. During the end-to-end tests, the phantoms were transferred through the workflow…

Incidence of mandibular osteoradionecrosis (MORN) after intensity modulated radiotherapy (IMRT) versus 3D conformal radiotherapy (3D-CRT): A systemat…

2022

Background: Analyze the incidence of MORN after head and neck radiotherapy by two novel irradiation techniques. 3DCRT and IMRT and compare the success rates of distinct authors. Material and Methods: An electronic search in Pubmed (MEDLINE), Ovid. Google Scholar and Cochrane Library (Wiley). databases was conducted with the key words Radiotherapy, Conformal[Mesh] OR Radiotherapy. Intensity-Modulated[Mesh]) AND Osteoradionecrosis[Mesh] for all databases. The inclusion criteria randomized controlled trials (RCT), as well as prospective and retrospective cohort studies published in English; MORN patients treated with 3D-CRT y IMRT. Results: 27 articles were selected from 194 initially found. 1…

Improving management of patients with head and neck cancer

2022

The management of cancer patients aims at ensuring the best treatment for the patient but also a better preservation of his quality of life. In this thesis work, we aimed to highlight how the implementation of patient-reported parameters such as quality of life into management could contribute to improve the management of head and neck cancer patients.Our first work, which aimed to study the impact of routine assessment of health related quality of life based on data from 200 patients who received radiotherapy as first-line treatment included in a randomized phase 3 trial, showed that assessing health related quality of life in daily clinical practice could lead to a clinically relevant imp…

Evaluation of halitosis and sialometry in patients submitted to head and neck radiotherapy

2009

Objectives: The aim of this study was to investigate the parameters of halitosis and sialometry in patients who had undergone head and neck radiotherapy, correlating oral concentration of volatile sulfur compounds (VSC) with the presence of tongue coating, salivary flow rate and BANA test. Material and Methods: 35 patients allocated in two groups were examined: group I (control) - patients with systemic and oral health; group II - patients submitted to head and neck radiotherapy. All volunteers were submitted to halitosis measurements through a sulphide monitor, evaluation of tongue coating weight, non-stimulated sialometry and BANA test. Results: The results were analyzed through analysis …

Rail track field testing using laser/air hybrid ultrasonic technique

2003

Nondestructive testing methods used for the testing of rail in tracks worldwide can be limited by discontinuity location or orientation within the rail. Vertical split head and rail base cracks are among those types of discontinuities that are difficult to detect, which in some cases may result in a reail failure in service. A noncontact and remote hybrid ultrasonic technique has been developed by combining laser generation with air coupled detection of ultrasonic signals in rails. The test apparatus mounts on a railroad pushcart and tests are performed in motion with all components kept above the running surface of the rail track. Tracks have been tested for vertical split head and rail ba…

Carboplatin in combination with raltitrexed in recurrent and metastatic head and neck squamous cell carcinoma: A multicentre phase II study of the Gr…

2005

ackground: The combination of cisplatin (CDDP) and 5-Fluorouracil (5-FU) is a standard regimen for the treatment of recurrent and metastatic head and neck squamous cell carcinoma (HNSCC). This combination shows a relevant toxicity and new chemotherapy associations with a more favourable toxicity profile are awaited. Carboplatin (CB) is a platinum derivative with less toxicity than CDDP. Raltitrexed (R) is a potent and specific thymidylate synthase inhibitor with activity comparable to that of 5-FU in colorectal cancer; moreover, it showed activity as a single agent in HNSCC. Materials and Methods: Since 2001, a multicentre, phase II trial has been underway to evaluate the efficacy and toxic…

Crosstalk of regulatory T cells and tolerogenic dendritic cells prevents contact allergy in subjects with low zone tolerance

2012

Background Allergic contact dermatitis is one of the most common occupational diseases. A main protective mechanism in those who do not develop allergic contact dermatitis is tolerance induction by repeated exposure to low doses of contact allergen, which is termed low zone tolerance (LZT). The mechanisms that determine the tolerance induction in subjects with LZT are still elusive. Objective We performed analysis of the role of CD4 + CD25 + forkhead box protein 3 (FOXP3)–positive regulatory T (Treg) cells and dendritic cells (DCs) in mice with LZT. Methods Mechanisms of tolerance induction were analyzed in a murine model of LZT by using FOXP3 and IL-10 reporter mice, as well as mice that a…