Search results for "Healing"

Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels

2019

Abstract Background Due to unmet need for bone augmentation, our aim was to promote osteogenic differentiation of human adipose stem cells (hASCs) encapsulated in gellan gum (GG) or collagen type I (COL) hydrogels with bioactive glass (experimental glass 2-06 of composition [wt-%]: Na2O 12.1, K2O 14.0, CaO 19.8, P2O5 2.5, B2O3 1.6, SiO2 50.0) extract based osteogenic medium (BaG OM) for bone construct development. GG hydrogels were crosslinked with spermidine (GG-SPD) or BaG extract (GG-BaG). Methods Mechanical properties of cell-free GG-SPD, GG-BaG, and COL hydrogels were tested in osteogenic medium (OM) or BaG OM at 0, 14, and 21 d. Hydrogel embedded hASCs were cultured in OM or BaG OM fo…

Agarose/k-Carrageenan-based hydrogel films enriched with natural extracts for wound healing applications

2019

Hydrogels are 3D hydrophilic networks that can hold significant amounts of water within their structure, without dissolving in water.

Sviluppo di spugne bioerodibili multifunzionali per la promozione di processi riparativi mediante il rilascio controllato di agenti antibiotici e ant…

2023

La salute delle strutture molli e dure del cavo orale è essenziale non solo per preservare le funzioni ad esse direttamente associate, ma anche per promuovere la salute generale dell’organismo. Tra le problematiche di maggiore interesse clinico a carico della cavità orale ritroviamo: i) le complicazioni post-operatorie che possono verificarsi a seguito di comuni avulsioni dentali che, se non trattate tempestivamente, possono sfociare in gravi parodontiti; ii) i fenomeni di osteonecrosi a carico di mascella e mandibola associate a trattamenti farmacologici nonché alla radioterapia; iii) il carcinoma orale a cellule squamose (OSCC) che è tra i più aggressivi tumori del collo e della testa, ca…

Advanced electrospun matrices based on polysaccharide derivatives for applications in regenerative medicine

2021

The complete regeneration of damaged human tissues and organs is still a significant challenge. The integrative use of biomaterials, cells and bioactive factors in all-in-one devices exploits all current knowledge of materials science, nanotechnology and stem cell biology to best mimic the complex hierarchical architecture of native tissues. The artificial microenvironment design must be properly tuned to match the physicochemical features of the target, offering adequate nanoscale patterns and biological domains for cellular interactions. Scaffolds must promote and guide the regeneration route by mimicking host signalling pathways through the controlled release and retention of drugs or gr…

Multicomponent Antibiofilm Lipid Nanoparticles as Novel Platform to Ameliorate Resveratrol Properties: Preliminary Outcomes on Fibroblast Proliferati…

2023

The well-being of skin and mucous membranes is fundamental for the homeostasis of the body and thus it is imperative to treat any lesion quickly and correctly. In this view, polyphenols might assist and enhance a successful wound healing process by reducing the inflammatory cascade and the production of free radicals. However, they suffer from disadvantageous physico–chemical properties, leading to restricted clinical use. In this work, a complex mixture of PEGylated lipid, Glyceryl monoester, 18-β-Glycyrrhetinic Acid and Menthol was designed to entrap Resveratrol (RSV) as the active ingredient and further produce lipid nanoparticles (LNPs) by homogenization followed by high-freq…

Management of Primary Non-Aggressive Mandibular Giant Cell Tumor: A 14 Years' Experience

2011

Giant cell tumor is a rare non-odontogenic lesion that represents approximately 4-5% of all primary bone tumors. Such lesions derive their actual name from the constant presence of numerous giant cells, similar to osteoclasts .All the giant cell tumors hystorically is treated with curettage. Because this conservative approach is often associated with a recurrence rate of up to 70% , aggressive resection has become the standard practice. Unfortunately ,recurrence after wide resection is about 7%. The aim of the study is to describe the 14 years single institution experience with management of primary non-aggressive giant cell tumor of the jaws bone.

Mucosal healing following PRP (Platelet-Rich Plasma) application in post-extraction socket in patients treated with aminobisphosphonates

2014

Use of porcine collagen matrix (Mucograft®) to promote the wound healing in the oral cavity

2015

The aim of this study was to evaluate the use of a new collagen matrix (Mucograft®; Geistlich Pharma AG, Wol- husen, Switzerland) in the soft tissue reconstruction after excisional biopsy. The healing of soft tissues after bioptical excision tends to heal by secondary intention. To avoid this, the soft tissue grafts can be harvested from the palate, retromolar pad, or (if available) edentulous site. Disadvantages of harvesting the graft from the retromolar pad and edentulous site are minimal amount of tissue availability and thinner grafts are obtained. The use of collagen matrix is also reported in literature and could represent an optimal solution in the future. Mucograft® is a pure colla…

Hastening of wound healing of mucosa by means of aminoacids combined to sodium hyaluronate after oral biopsy: an open trial.

2014

Sodium hyaluronate has been widely used in order to promote wound healing in oral cavity for its anti-inflammatory effects. Aim of this clinical trial was to evaluate the efficacy of aminoacids added to topical sodium hyaluronate, in minor oral surgery. After surgery by means of Quantic molecular resonance scalpel, in 27 patients a gel with sodium hyaluronate has been applied directly on the surgical wound, in order to favorite healing by secondary intention. Furthermore, gel has been applied 3-4times/day, after meals and oral hygiene. Hemostatic effect, edema and pain symptoms by VAS (Visual Analogue Scale;0-100), and clinical healing (full, partial, absent) have been evaluated at T#1(2hrs…

Evolution and healing of fragility fractures of the proximal femur

2014

After a traumatic fracture a physiological process begins to heal the fracture. The steps of the process are inflammation, granulation, formation of fibrous callus and finally bone. There are many factors that may influence the healing of the fracture: adequate blood supply, good contact between bone fragments, good stability of the fracture, general health, age, smoking, related pathology, use of drugs, etc. In elderly patients the variations in bone structure and healing processes have a negative influence on fracture healing. Fragility fractures require careful placement of the implants to reduce the risk of failure of osteosynthesis. Appropriate surgical devices and facilitation factors…