Search results for "Health sciences"
showing 5 items of 34315 documents
Zebrafish and other aquatic models in Mediterranean labs; THE ZEBRAFISH MODEL IN BIOTECHNOLOGY AND HEALTH SCIENCES
2017
Modeling multipartite virus evolution: the genome formula facilitates rapid adaptation to heterogeneous environments
2020
Multipartite viruses have two or more genome segments, and package different segments into different particle types. Although multipartition is thought to have a cost for virus transmission, its benefits are not clear. Recent experimental work has shown that the equilibrium frequency of viral genome segments, the setpoint genome formula (SGF), can be unbalanced and host-species dependent. These observations have reinvigorated the hypothesis that changes in genome-segment frequencies can lead to changes in virus-gene expression that might be adaptive. Here we explore this hypothesis by developing models of bipartite virus infection, leading to a threefold contribution. First, we show that th…
IME/Índice Médico Español. Perspectivas y retos tras 40 años de tradición bibliográfica en ciencias de la salud (1964-2003).
2004
Al cumplir cuarenta años de pervivencia, la base de datos IME, versión automatizada del repertorio Índice Médico Español, constituye la mayor base de datos bibliográfica sobre publicaciones en ciencias de la salud en español. Actualmente ha iniciado una nueva etapa en la que pretende responder a las nuevas exigencias de la sociedad mediante la incorporación de algunas innovaciones documentales y tecnológicas. Para ello, se ha mejorado el sistema de gestión de la base de datos mediante aplicaciones que permiten el teletrabajo en tiempo real y la actualización constante de los registros. Además, se ha ampliado su cobertura con la incorporación de nuevas revistas, algunas de ellas electrónicas…
INFLUENCIA DE FACTORES FAMILIARES Y PERSONALES EN LA EVOLUCIÓN NEGATIVA DEL TDAH
2016
Abstract.INFLUENCE OF PERSONAL AND FAMILY FACTORS ON THE NEGATIVE COURSE OF ADHDObjective. To study the effect of the cumulative adversity on the course of ADHD symptoms, associated problems and dysfunctionality of ADHD children. Method. 61 families of children with a clinical diagnosis of ADHD combined subtype were evaluated on two different times (Time I: mean age = 8.7; Time II: mean age = 11). We developed a personal risk index (high levels of ADHD symptoms, high number of associated problems, presence of oppositionism, stressful child characteristics and family history of ADHD), a family risk index (presence of mothers’ psychopathology, high parental stress and dysfunctional discipline…
WDR45 Gene and Its Role in Pediatric Epilepsies
2021
AbstractWD repeat domain 45 (WDR45) gene has been increasingly found in patients with developmental delay (DD) and epilepsy. Previously, WDR45 de novo mutations were reported in sporadic adult and pediatric patients presenting iron accumulation, while heterozygous mutations were associated with β-propeller protein-associated neurodegeneration (BPAN), a subtype of neurodegeneration with brain iron accumulation disorders, characterized by extrapyramidal movement disorders and abnormal accumulation of iron in the basal ganglia. Overall, people harboring WDR45 mutations have moderate to severe DD and different types of seizures. The phenotype of adult patients is characterized by extrapyramidal…