Search results for "Healthy subject"
showing 10 items of 195 documents
Quantification of Different Regulatory Pathways Contributing to Heartbeat Dynamics during Multiple Stimuli: a Proof of the Concept.
2019
The dynamical interplay between brain and heart is mediated by several feedback mechanisms including the central autonomic network and baroreflex loop at a peripheral level, also for a short-term regulation. State of the art focused on the characterization of each regulatory pathway through a single stressor elicitation. However, no studies targeted the actual quantification of different mediating routes leading to the generation of heartbeat dynamics, particularly in case of combined exogenous stimuli. In this study, we propose a new approach based on computational modeling to quantify the contribution of multiple concurrent stimuli in modulating cardiovascular dynamics. In this prelimina…
Quantifying multidimensional control mechanisms of cardiovascular dynamics during multiple concurrent stressors
2021
Heartbeat regulation is achieved through different routes originating from central autonomic network sources, as well as peripheral control mechanisms. While previous studies successfully characterized cardiovascular regulatory mechanisms during a single stressor, to the best of our knowledge, a combination of multiple concurrent elicitations leading to the activation of different autonomic regulatory routes has not been investigated yet. Therefore, in this study, we propose a novel modeling framework for the quantification of heartbeat regulatory mechanisms driven by different neural routes. The framework is evaluated using two heartbeat datasets gathered from healthy subjects undergoing p…
Neural and muscular changes after 4 and 8 weeks of electromyostimulation training
2005
Electromyostimulation (EMS) has been recently used as a modality of resistance training in healthy subjects to enhance maximal voluntary strength (Duchateau 1990, Maffiuletti 2002). The underlying ...
The Impact of Depression Symptoms in Patients with Parkinson’s Disease: A Novel Case-Control Investigation
2021
Parkinson’s disease is a common neurodegenerative disease and it is known to cause motor disturbances associated with musculoskeletal problems of the locomotor apparatus, and non-motor symptoms, that are believed to have a harmful effect on health, social functioning and mobility. The aim of this study was to evaluate depression in patients with Parkinson’s Disease (PD) compared to subjects who do not have it. The sample consisted of 124 participants (mean age 69.18 ± 9.12). Patients with PD were recruited from a center of excellence for Parkinson’s disease (cases n = 62) and healthy subjects without PD from their relatives and caregivers (control n = 62). The Spanish version of Beck’s Depr…
Das chemotaktische Verhalten von Alveolarmakrophagen und Blutmonozyten nach Expositionen mit unterschiedlichen NO2-Konzentrationen
2008
The chemotaxis of alveolar macrophages (AM) and blood monocytes (BM) is important in the elimination of particles and microorganisms which have invaded the lung. The effect of nitrogen dioxide (NO2) on chemotaxis was tested on AM obtained by diagnostic bronchoscopy from five patients suspected of having bronchial carcinoma (four men, one woman; mean age 59 +/- 10 years). Blood monocytes were also studied with blood from seven healthy subjects (five men, two women; mean age 32 +/- 10 years). These cells were placed on polycarbonate membranes for 15 min each, exposed to NO2 concentrations between 1.0 and 5.0 parts per million (ppm), and then incubated with complement component C5a as chemotac…
Analysis of the Possible Persistent Genotoxic Damage in Workers Linked to the Ardystil Syndrome
2016
[EN] Background: A combination of several factors including a change in the paint application system; a lack of proper hygiene; and inadequate safety measures caused a severe health impact in the workers of some textile painting factories. This outbreak, mainly characterized by respiratory disorders, caused the death of six people and it has been classified as Ardystil syndrome. Materials and Methods: Fifty-two workers involved in the outbreak and 48 healthy subjects not known to have exposed to the potentially mutagenic agents participated in the study. The program evaluated possible genotoxic damage through the sister chromatid exchange (SCE) cytogenetic biomarker assay. We determined the…
A screening instrument for a Sicilian neuroepidemiological survey in the elderly.
2003
Abstract We evaluated the sensitivity and specificity of a screening instrument developed for use in a two-phase neuroepidemiological survey in Sicily. The Sicilian Epidemiological Dementia Study (SEDES) project will evaluate the prevalence and incidence of dementia, parkinsonisms and essential tremor in four Sicilian municipalities. It is a two-phase door-to-door survey. To identify subjects with possible neurological disorders, in this study, we developed a screening instrument including a symptoms questionnaire and simple physical tasks for parkinsonisms and essential tremor. The Mini-Mental State Examination (MMSE) was chosen for screening dementia. The symptoms questionnaire and simple…
Association of γδ T Cells with Disease Severity and Mortality in Septic Patients
2013
ABSTRACTGamma-delta T cells are the most abundant of all epithelial-resident lymphocytes and are considered a first line of defense against pathogens in the mucosa. Our objective was to confirm the reduction in γδ T cell subsets and its relationship with mortality in patients with sepsis. We studied 135 patients with sepsis attended in the emergency department and intensive care unit of two hospitals and compared them with a similar control group of healthy subjects. The αβ and γδ T cell subsets were determined via flow cytometry according to the stage of the sepsis and its relationship with mortality. All the lymphocyte subsets were reduced with respect to the corresponding subsets in the …
Intravenous bisphosphonate-related osteonecrosis of the jaws: Influence of coadjuvant antineoplastic treatment and study of buccodental condition
2012
Objectives: To determine whether coadjuvant antineoplastic treatment can influence the number and size of bone exposures among patients with intravenous bisphosphonate-related osteonecrosis of the jaws (iBRONJ), and to analyze the buccodental condition of these patients. Material and methods: The study sample comprised 67 patients with iBRONJ, 53 patients without iBRONJ receiving treatment with intravenous bisphosphonates, and 36 healthy subjects. In all three groups, measurements were made of the CAO index and of resting whole saliva and stimulated whole saliva. In the patients with iBRONJ, the size (cm) and number of bone exposures were recorded. The data obtained were subjected to analys…
The role of right and left posterior parietal cortex in the modulation of spatial attentional biases by self and non-self face stimuli
2012
In the present research we investigated whether the direction of the attentional bias in line bisection judgment displayed by healthy subjects is influenced by the evaluation of the social distance between self and other. We used inhibitory repetitive transcranial magnetic stimulation (rTMS) trains over the right and left parietal cortex to investigate the role of these regions in the task. Following right parietal rTMS, the self face is perceived as closer when it is located at the right line endpoint; following left parietal rTMS, the self face is perceived as closer when it is located at the left line endpoint. In both cases, the side of space ipsilateral to the rTMS is underestimated fr…