Search results for "Healthy subjects"
showing 10 items of 193 documents
Large-scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients.
2017
Objectives The human brain is organized into large-scale networks that dynamically interact with each other. Extensive evidence has shown characteristic changes in certain large-scale networks during transitions from internally directed to externally directed attention. The aim of the present study was to compare these context-dependent network interactions during emotion regulation and to examine potential alterations in remitted unipolar and bipolar disorder patients. Methods We employed a multi-region generalized psychophysiological interactions analysis to quantify connectivity changes during distraction vs reappraisal pair-wise across 90 regions placed throughout the four networks of i…
Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applic…
2020
Fluid sampling from the gastrointestinal (GI) tract has been applied as a valuable tool to gain more insight into the fluids present in the human GI tract and to explore the dynamic interplay of drug release, dissolution, precipitation and absorption after drug product administration to healthy subjects. In the last twenty years, collaborative initiatives have led to a plethora of clinical aspiration studies that aimed to unravel the luminal drug behavior of an orally administered drug product. The obtained drug concentration-time profiles from different segments in the GI tract were a valuable source of information to optimize and/or validate predictive in vitro and in silico tools, freque…
The Influence of All-Night Exposure to Pulsed Radiofrequency Electromagnetic Fields on Human Sleep. Der Einfluss kontinuierlicher nachtlicher Exposit…
2005
Question of the study The widespread use of mobile telephones has led to public discussion about the putative health hazards as well as scientific interest in the interactions of pulsed, high-frequency electromagnetic fields with physiological systems. This article presents a survey of three consecutive studies carried out by a research group at the University of Mainz.
Contributions regarding 3D modelling of biomechanics of the foot
2021
Within this paper, a detailed study is elaborated regarding the human foot during both orthostatic and gait, the main goal being to develop 3D models which are very useful in the foot motion and loading state research. In order to elaborate the accurate 3D modelling of the human foot assembly, a thorough biomechanical study is done. Such a study was required due to the fact of the high anatomical complexity of the motions within the foot, taking into consideration the 26 bones and 33 joints consisting it. The research aims the CAD modelling of the biomechanics of the healthy subjects alongside with predisposed pathological conditions. The resulting models will have important utility in both…
Spontaneous Endoreduplication, Tetraploidy and Chromosome Breakage in Lymphocyte Cultures from Healthy Subjects
1984
SUMMARY42,703 metaphases of peripheral lymphocytes from 20 healthy subjects (10 women and 10 men) were examined in order to establish the frequency of endoreduplicated cells and of tetraploid cells without diplochromosomes. Frequencies were found to be 0.016% and 0.112%, respectively. The two sexes did not differ as to the frequency of tetraploid cells, with and without diplochromosomes (about 0.13% in either sex). In a total of 2,135 well spread metaphases examined, 26 cells (i.e. 1.2%) with chromosomal breaks were found. Again, no significant differences between the two sexes were found as to such chromosome abnormalities.
Granger causality analysis of sleep brain-heart interactions
2014
We studied the networks of Granger causality (GC) between the time series of cardiac vagal autonomic activity and brain wave activities, measured respectively as the normalized high frequency (HF) component of heart rate variability and EEG power in the δ, θ, α, Ï, β bands, computed in 10 healthy subjects during sleep. GC analysis was performed by vector autoregressive modeling, and significance of each link in the network was assessed using F-statistics. The whole-night analysis revealed the existence of a fully connected network of brain-heart and brain-brain interactions, with the à EEG power acting as a hub which conveys the largest number of GC links between the heart and brain n…
Desoxyribonuclease-Aktivität im Seminalplasma von normalem und pathologischem Sperma1
2009
Zusammenfassung Das Verteilungsmuster der DNase-Aktivitaten im Seminalplasma von 9 Normalpersonen und 18 Patienten mit einem pathologischen Spermabefund wurde mit dem mikro-disc-elektrophoretischen Verfahren untersucht. Dabei ergaben die Aktivitatsbestimmungen der DNase bei Patienten mit einer Oligoasthenoteratozoospermie als auch bei alien Probanden, die einen pathologischen Spermabefund aufwiesen, in der 1. und 2. Bande deutliche Aktivitatsminderungen im Vergleich zum Seminalplasma von Normalpersonen. Nach den vorliegenden Untersuchungsbefunden stellt sich die Frage, ob den DNasen im Seminalplasma die Aufgabe zukommt, geschadigte und uberalterte Spermatozoen, deren Membran permeabler gewo…
Vers des normes francophones pour le Rorschach en système intégré : premiers résultats sur un échantillon de 146 adultes
2004
Resume Cet article presente les principales caracteristiques de l'etude normative francophone pour le Rorschach en systeme integre dans une population adulte. Apres une revue des experiences precedentes, nous justifions les choix methodologiques effectues. Ceux-ci passent par une definition claire de l'echantillon, un controle serre du recrutement des participants, des procedures de qualite mises en œuvre a plusieurs niveaux dans le recueil de donnees. Les resultats de la premiere phase de recueil (n = 146) sont presentes et les principales variables et scores derives du Rorschach sont decrits. Certaines variables cles donnent lieu a comparaison avec les echantillons utilises jusqu'a presen…
Quantification of Different Regulatory Pathways Contributing to Heartbeat Dynamics during Multiple Stimuli: a Proof of the Concept.
2019
The dynamical interplay between brain and heart is mediated by several feedback mechanisms including the central autonomic network and baroreflex loop at a peripheral level, also for a short-term regulation. State of the art focused on the characterization of each regulatory pathway through a single stressor elicitation. However, no studies targeted the actual quantification of different mediating routes leading to the generation of heartbeat dynamics, particularly in case of combined exogenous stimuli. In this study, we propose a new approach based on computational modeling to quantify the contribution of multiple concurrent stimuli in modulating cardiovascular dynamics. In this prelimina…
Quantifying multidimensional control mechanisms of cardiovascular dynamics during multiple concurrent stressors
2021
Heartbeat regulation is achieved through different routes originating from central autonomic network sources, as well as peripheral control mechanisms. While previous studies successfully characterized cardiovascular regulatory mechanisms during a single stressor, to the best of our knowledge, a combination of multiple concurrent elicitations leading to the activation of different autonomic regulatory routes has not been investigated yet. Therefore, in this study, we propose a novel modeling framework for the quantification of heartbeat regulatory mechanisms driven by different neural routes. The framework is evaluated using two heartbeat datasets gathered from healthy subjects undergoing p…