Search results for "Heart"
showing 10 items of 3201 documents
Work-loss years among people diagnosed with diabetes: a reappraisal from a life course perspective
2018
Aims Early exit from the workforce has been proposed to be one of the unfavorable consequences of diabetes. We examined whether early exit from the workforce differed between persons who were and were not diagnosed with diabetes during their work career. Methods The cohort included 12,726 individuals of the Helsinki Birth Cohort Study, born between 1934 and 1944. Using data from nationwide registers, the cohort was followed up from early adulthood until they transitioned into retirement or died. Work- loss years were estimated using the restricted mean work years method. Results During a follow-up of 382,328 person-years for men and 349 894 for women, 36.8% transitioned into old age pension…
Care Dependency in Patients with Heart Failure: A Cross-Sectional Study in Spain.
2020
Background: Heart failure (HF) is a progressive and debilitating condition that represents an ever-growing problem for health systems worldwide. HF patients feel that they are a burden on their families, they feel socially isolated and have a low perception of their health. Accordingly, the objectives of this study were to: (1) to explore the profile of care dependency in a representative sample of Spanish HF patients through the Care Dependency Scale (CDS), and (2) to identify correlates of care dependency in this population. Material and Methods: We performed a cross-sectional study of 187 patients admitted for HF decompensation to the Hospital Clínico of Zaragoza (Spain). Results: Only 1…
Even a low-dose of moderate-to-vigorous physical activity reduces mortality by 22% in adults aged ≥60 years: a systematic review and meta-analysis
2015
Type de document : revue de littérature; International audience; Background The health benefits of 150 min a week of moderate-to-vigorous-intensity physical activity (MVPA) in older adults, as currently recommended, are well established, but the suggested dose in older adults is often not reached.Objectives We aimed to determine whether a lower dose of MVPA was effective in reducing mortality, in participants older than 60 years.Methods The PubMed and Embase databases were searched from inception to February 2015. Only prospective cohorts were included. Risk ratios of death were established into four doses based on weekly Metabolic Equivalent of Task (MET)-minutes, defined as inactive (refe…
Identifying poor cardiorespiratory fitness in overweight and obese children and adolescents by using heart rate variability analysis under resting co…
2020
Background: Childhood obesity, including overweight, continues increasing worldwide affecting health expectancy, quality of life and healthcare expenditure. These subjects have higher probability of suffering or developing cardio metabolic risk factors. Recent studies have revealed cardiorespiratory fitness (CRF) as a valuable clinical parameter to identify these subjects and have even suggested cut-off values. However, evaluating CRF in overweight and obese youth can be difficult to implement, unfriendly and expensive. Objective: Develop a screening tool to identify high-risk subjects in a representative population of those attending overweight/obesity assessment programmes without prior i…
Associations of vacation time with lifestyle, long-term mortality and health-related quality of life in old age: The Helsinki Businessmen Study
2017
Abstract Introduction There are few longitudinal studies of relationships between vacation and later health outcomes. We studied these during a 26-year follow-up of the Helsinki Businessmen Study. Methods In 1974, at mean age of 47 years, 2741 members of a cohort of executives and businessmen born 1919–1934 were clinically examined and reported their annual vacation time (dichotomized >21 [n = 2001] vs. ≤21 days [n = 740]), self-rated health (SRH) and perceived physical fitness using a five-step scale. In old age in 2000 (mean age 73 years), the survivors filled in the RAND-36/SF-36 health-related quality of life (HRQoL) questionnaire. Mortality between 1974 and 2000 was retrieved from nati…
Consequences and comorbidities associated with obesity
2017
This chapter reviews the importance of diabetes as a major complication of obesity, starting with examining the epidemiological relationship between diabetes and obesity. It is clear from the epidemiological data reported that obesity is strongly associated with onset and, in particular, the premature onset, of type 2 diabetes. However, in established heart disease and heart failure, obesity is associated with lower mortality. The chapter considers the epidemiological evidence linking adiposity with the development of cancer, and describes the proposed mechanisms by which excess body fat may impact on cancer risk. The global prevalence of osteoarthritis continues to rise, both because of an…
Heart Rate Variability Recordings are a Valid Non- Invasive Tool for Evaluating Soldiers’ Stress
2013
Heart Rate Variability Recordings are a Valid Non- Invasive Tool for Evaluating Soldiers’ Stress The purpose of the present study was to investigate physiological responses and to evaluate heart rate variability as a non-invasive stress indicator during a 72-hour military field training (MFT). Ten healthy male soldiers (age 20 ± 1 yr.) participated in MFT. They slept approximately 2 h/day and ate only army field rations. During MFT, the soldiers’ mean (±SD) energy expenditure was 4646 ± 674, energy intake 2200 ± 326, and energy deficit (ED) 2405 ± 890 kcal⋅day-1.Throughout the entire training period, serum total testosterone (TES) reduced from 19.0 ± 3.0 to 12.6 ± 6.2 nmol⋅l-1 (p<0.001)
No influence of oxygen levels on pathogenesis and virus shedding in Salmonid alphavirus (SAV)-challenged Atlantic salmon (Salmo salar L.)
2010
Abstract Background For more than three decades, diseases caused by salmonid alphaviruses (SAV) have become a major problem of increasing economic importance in the European fish-farming industry. However, experimental infection trials with SAV result in low or no mortality i.e very different from most field outbreaks of pancreas disease (PD). This probably reflects the difficulties in reproducing complex biotic and abiotic field conditions in the laboratory. In this study we looked at the relationship between SAV-infection in salmon and sub-lethal environmental hypoxia as a result of reduced flow-through in tank systems. Results The experiment demonstrated that constant reduced oxygen leve…
Clinical Predictors of Immunotolerance in Heart Transplantation
2010
Abstract Background and Aim The drugs routinely administered to prevent rejection often cause lethal side effects. Tolerant patients, therefore, should be identified to minimize these problems. The aim of this analysis was to identify clinical variables that may be associated with tolerance. Methods We recruited 522 heart transplants (HT), excluding combined procedures, retransplantations, pediatric recipients, and subjects who died in the first year to obtain a cohort of 375 patients. Two groups were distinguished by the presence of echocardiographic, clinical, or pathological evidence of rejection in the first year (15 echocardiograms and 10 protocol biopsies per patient); 99 tolerant pat…
Protective role of the complement regulatory protein human CD-55 in cardiac xenograft: a descriptive study and a revision of the literature.
2002
The limited and inadequate availability of organs from human donors has resulted in the utilisation of xenografts as an alternative tool. Nevertheless, hyperacute rejection (HAR) following xenograft determines the loss of the transplanted organ. The “primum movens” is the activation of the complement pathway mediated by the binding of natural xenogenic antibodies to the endothelium of the graft, followed by the lysis of the endothelial cells with subsequent oedema, thrombosis and necrosis of the transplanted organ. In this work we describe morphological and biomolecular observations of isolated human-decay accelerating factor (h-DAF, CD55) transgenic pig hearts, after perfusion for four hou…